Preschool wheeze – impact of early fish introduction and neonatal antibiotics

Goksör, Emma; Alm, Bernt; Thengilsdottir, Hrefna; Pettersson, Robert; Åberg, Nils; Wennergren, Göran

doi:10.1111/j.1651-2227.2011.02411.x

Cited by 51 publications

(90 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most studies have been carried out in older children or assessed the timing of introduction of fish in the infant' s diet rather than the amount of fish consumption afterward. However, Goksor et al 11 showed that early fish introduction, but not the frequency of fish consumption at 12 months, was associated with recurrent wheeze, which is in line with our results. Similar results were also found in the Prevention of Allergy Among Children in Trondheim study.…”

Section: Discussionsupporting

confidence: 83%

“…Various studies have suggested that early life exposure of n-3 polyunsaturated fatty acids (n-3 PUFA), a major component in fatty fish, protects against the development of asthma. 2,9,10 In line with this, a recent study reported a beneficial effect of introduction of fish before age 9 months on the development of wheezing at age 4.5 years, 11 whereas another study reported no association between introduction of fish and asthma. 12 However, because fish can also be highly allergenic, 13 the optimal timing of introduction of fish in the infant' s diet and the adequate amount remains unclear.…”

Section: Discussionsupporting

confidence: 59%

See 1 more Smart Citation

Fish Consumption in Infancy and Asthma-like Symptoms at Preschool Age

Jong

Vries²,

Franco³

et al. 2012

Pediatrics

View full text Add to dashboard Cite

OBJECTIVE: To assess whether timing of introduction of fish and the amount of fish consumption in infancy were associated with asthmalike symptoms at preschool age. METHODS: This study was embedded in the Generation R study (a population-based birth cohort in Rotterdam, Netherlands). At the age of 12 and 14 months, timing of introduction of fish into the infant’s diet was assessed. The amount of fish consumption at 14 months was assessed by a semiquantitative food frequency questionnaire. Presence of asthmalike symptoms in the past year was assessed at the child’s age of 36 and 48 months. RESULTS: Relative to no introduction in the first year of life, introduction between age 6 and 12 months was significantly associated with a lower risk of wheezing at 48 months (odds ratio [OR]: 0.64; 95% CI: 0.43–0.94). When compared with introduction between 6 and 12 months, no introduction in the first year and introduction between 0 and 6 months were associated with an increased risk of wheezing at 48 months (OR: 1.57; 95% CI: 1.07–2.31 and OR: 1.53; 95% CI: 1.07–2.19, respectively). The amount of fish at age 14 months was not associated with asthmalike symptoms (P > .15). CONCLUSIONS: Introduction of fish between 6 and 12 months but not fish consumption afterward is associated with a lower prevalence of wheezing. A window of exposure between the age of 6 and 12 months might exist in which fish might be associated with a reduced risk of asthma.

show abstract

Section: Discussionsupporting

confidence: 83%

Section: Discussionsupporting

confidence: 59%

Fish Consumption in Infancy and Asthma-like Symptoms at Preschool Age

Jong

Vries²,

Franco³

et al. 2012

Pediatrics

View full text Add to dashboard Cite

show abstract

“…Despite significant differences in clinical presentation, lung function and genetics between children with EVW and MTW phenotypes, there is a large overlap between the groups [16][17][18][19]. While some children retain a consistent pattern of EVW or MTW over longer periods, symptom patterns change over time in many [15].…”

Section: Distinguishing Between Evw and Mtwmentioning

confidence: 99%

Classification and pharmacological treatment of preschool wheezing: changes since 2008

et al. 2014

View full text Add to dashboard Cite

Since the publication of the European Respiratory Society Task Force report in 2008, significant new evidence has become available on the classification and management of preschool wheezing disorders. In this report, an international consensus group reviews this new evidence and proposes some modifications to the recommendations made in 2008. Specifically, the consensus group acknowledges that wheeze patterns in young children vary over time and with treatment, rendering the distinction between episodic viral wheeze and multiple-trigger wheeze unclear in many patients. Inhaled corticosteroids remain first-line treatment for multiple-trigger wheeze, but may also be considered in patients with episodic viral wheeze with frequent or severe episodes, or when the clinician suspects that interval symptoms are being under reported. Any controller therapy should be viewed as a treatment trial, with scheduled close follow-up to monitor treatment effect. The group recommends discontinuing treatment if there is no benefit and taking favourable natural history into account when making decisions about long-term therapy. Oral corticosteroids are not indicated in mild-to-moderate acute wheeze episodes and should be reserved for severe exacerbations in hospitalised patients. Future research should focus on better clinical and genetic markers, as well as biomarkers, of disease severity.

show abstract

“…Fish consumption in infancy has been studied as the time of introduction in some studies and as the frequency of intake in other studies. In most studies, fish in the child's diet has been associated with reduced risk of eczema, rhinitis, wheeze, and asthma up to preschool age (11)(12)(13)(14)(15)(16)(17)(18). However, there have also been reports of no association with allergic disease (19).…”

Section: Introductionmentioning

confidence: 94%

“…If such recommendations were followed, leading to delayed introduction and, thereby, a lower intake of fish in these children, this disease-related modification of exposure may bias studies on fish consumption in infancy. Therefore, most recent studies on early fish consumption have taken the disease-related modification of exposure into account in different ways (11,(13)(14)(15)(16)(17)(18). Today, such recommendations are not given (22,23), and fish is considered a healthy food.…”

Section: Introductionmentioning

confidence: 99%