“…There is compulsory generic substitution in South Africa unless otherwise specified by the physician or the patient prefers to pay for the more expensive originator. This is unlikely in this case in view of the price difference (170,171). Her study found that the originator constituted only 3.7% of the analgesics prescribed (average cost was R30.42) compared to 70.6% for the most popular branded generic, with a cost of R11.65 (170,171).…”