Prescribing Pattern of Antimicrobial Agents in Neonates at Nepalgunj Medical College, Kohalpur, Banke, Nepal

Neupane, Ganesh Prasad; Rai, Maya; Dhami, Dabal Bahadur; Singh, Ritesh

doi:10.3126/jngmc.v15i1.23560

Cited by 3 publications

(4 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our study documents a high prescription rate of antibiotics in neonates particularly from the Watch category. Concordant to our study high antibiotic prescription has been reported from countries like Rwanda (88%), 11 Nepal (96%) 12 and Zimbabwe (98%). 13 However, a relatively low prescription rate has also been reported from India (71% in teaching hospital) 14 and Iran (72%).…”

Section: Discussionsupporting

confidence: 91%

“… 20 Meropenem prescription in our study was two times higher compared to 9% in a study from China 21 and many folds higher than a study from USA 22 (0.7%). Vancomycin use in our study was comparable to study 22.7% 12 from Nepal but higher than study from Iran – 12%. 15 These variations could be due to difference in study population, common pathogens isolated from the neonatal units, their antibiotic sensitivity patterns and number of sick neonates referred from secondary care hospitals.…”

Section: Discussionsupporting

confidence: 77%

“…In more than 90% of the cases Ampicillin was combined with third generation Cephalosporin. Polypharmacy rate in our study was comparable to study from Nepal 12 but higher than study from Iran reporting 63%. 15 This pattern is against the WHO guidelines for using 60% of antibiotics from Access class 10 and indicates lack of standard treatment protocols for empirical therapy in suspected neonatal infections.…”

Section: Discussionsupporting

confidence: 74%

“…However, in a study from Nepal neonatal sepsis was common admission diagnosis - 47.3%. 12 Most common antibiotics used in neonates with birth asphyxia were Ampicillin + Cefoperazone and Ampicillin + Cefotaxime. Antibiotics utilized in a multicenter study of neonates with hypoxic-ischemic encephalopathy were ampicillin (87.9%), gentamicin (65.7%), and cefotaxime (37.2%).…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Pattern of hospital antibiotic use in term neonates using WHO Access, Watch and Reserve Classification (AWaRe)

Khalid

Rasheed²,

Nawaz³

2022

Pak J Med Sci

View full text Add to dashboard Cite

Background and Objective: Pakistan has high neonatal mortality rate and antibiotic utilization data in hospitalized term neonates from Pakistan is lacking. The study aimed to determine the pattern of hospital antibiotic use in term neonates using World Health Organization (WHO) Access, Watch, and Reserve classification (AWaRe). Methods: This cross-sectional chart review study was conducted at the neonatal unit of Pediatric Medicine Department of University Hospital over a period of one year from 1st January 2020 to 31st December 2020. Hospitalized full term newborns up to 28-days of life, of either gender were consecutively included in the study. Data on demographic characteristics, admission diagnoses and antibiotic prescribed (class, agent and duration) were extracted from clinical charts. Descriptive statistics in the form of mean ± SD and frequency and percentages were calculated. Results: A total of 2276 term neonates consisting of 69% (n=1570) males were included in the study. Antibiotic prescription rate was 92.8%. Most common reason for admission was birth asphyxia (36.1%) followed by sepsis (33%). Most commonly prescribed antibiotic Ampicillin (84%) belonged to Access group of WHO – AWaRe classification. More than 97% of prescriptions were two or more antimicrobial combinations belonging to Watch group. Ampicillin and Cefoperazone was the most commonly prescribed (42.8%) two drug combination. Meropenem and vancomycin was prescribed to 20% of the neonates – mostly for sepsis and pneumonia. Mortality rate was 7.7% in current study. Conclusion: High antibiotic prescription rate particularly from Watch-group is demonstrated in this study. There is high need of antimicrobial stewardship program in neonatal units. doi: https://doi.org/10.12669/pjms.38.8.6098 How to cite this:Khalid M, Rasheed J, Nawaz I. Pattern of hospital antibiotic use in term neonates using WHO Access, Watch and Reserve Classification (AWaRe). Pak J Med Sci. 2022;38(8):---------. doi: https://doi.org/10.12669/pjms.38.8.6098 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 77%

Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Pattern of hospital antibiotic use in term neonates using WHO Access, Watch and Reserve Classification (AWaRe)

Khalid

Rasheed²,

Nawaz³

2022

Pak J Med Sci

View full text Add to dashboard Cite

show abstract

Retracted: Drug Utilization Pattern of Antibiotics in Neonatal intensive care unit in a Tertiary Care Hospital, India

G Doddawad

2024

Ross. vestn. perinatol. pediatr.

View full text Add to dashboard Cite

Millions of babies are admitted to neonatal intensive care units worldwide, with a significant proportion facing various indications. Given that sepsis is a leading cause of mortality and morbidity among infants globally, including in India, the importance of efficient antibiotic use cannot be overstated. As the global problem of drug resistance intensifies, prudent antibiotic usage becomes crucial in mitigating treatment failures and ensuring the survival of newborns. Aim: to evaluate the pattern of antimicrobial drug utilization in neonatal intensive care unit (NICU) to assess the criteria for drug selection in tertiary care hospital.Materials and Methods. It was an observational prospective study conducted for six months in which 200 neonates admitted to neonatal intensive care unit at tertiary care Hospital, were included. Demographic details, duration of hospital stay, reason for admission (disease pattern), various drugs prescribed were noted. Results. Out of 200 neonates the number of male babies admitted to neonatal intensive care unit were 115 (57.5%) and female babies were 85 (42.5%). Many of the neonates were from age group of 1 to 5 (58.5%) days. Most of the neonates were from weight group of 2.5 to 3 (26.5%) kg. Majority of neonates hospital admission duration was 3 to 6 days is 98 (49%) neonates. Most common disorder requiring neonatal intensive care unit admission was Preterm with Respiratory Distress Syndrome (29%) followed by Neonatal Sepsis (19.5%) and Preterm (11%). Other distress reported include birth asphyxia (16 neonates or 8%), Neonatal convulsions (12 neonates or 6%), Late preterm (13 neonates or 6.5%), Hypernatremia (9 neonates or 4.5%), Meconium Aspiration Syndrome (3 neonates or 1.5%), Neonatal Hypoglycemia (5 neonates or 2.5%) and others (23 neonates or 11.5%). Among 423 antibiotics most prescribed antibiotic was Inj. Piperacillin + Tazobactam (35.4%) followed by Gentamycin (30.2%). Out of 423 drugs 152 are fixed dose combination and single drugs are 271 in this study in which piperacillin + tazobactam of fixed dose combination and gentamicin dose combination and single drugs are 271 in this study in which piperacillin + tazobactam of fixed dose combination and gentamicin of single drug had prescribed in more amount.Conclusion. The findings of this study will contribute to the existing body of knowledge regarding the appropriate use of antibiotics in the NICU, thereby providing insights for healthcare professionals to make informed decisions regarding antibiotic therapy. Empirical antibiotics were administered to every newborn based on their individual conditions. The antibiotic utilization pattern within this study group was determined to be rational.

show abstract

Drug Utilization Pattern of Antibiotics in Neonatal Intensive Care Unit at a Tertiary Care Hospital, Mysuru, Karnataka

Pushpa,

Pallda,

Sudharman

et al. 2023

Asian Journal of Pharmaceutical Research and Health Care

View full text Add to dashboard Cite

Introduction: Millions of babies are admitted to neonatal intensive care units (ICUs) worldwide, with a significant proportion facing various indications. Given that sepsis is a leading cause of mortality and morbidity among infants globally, including in India, the importance of efficient antibiotic use cannot be overstated. As the global problem of drug resistance intensifies, prudent antibiotic usage becomes crucial in mitigating treatment failures and ensuring the survival of newborns. Aim: The aim of this study was to evaluate the pattern of antimicrobial drug utilization in neonatal intensive care unit (NICU) to assess the criteria for drug selection in a tertiary care hospital. Materials and Methods: It was an observational, prospective study conducted for 6 months in which 200 neonates admitted to the NICU at a tertiary care hospital were included in the study. Results: Out of 200 neonates, the number of male babies admitted to NICU was 115 (57.5%) and female babies were 85 (42.5%). Many of the neonates were from the age group of 1 to 5 days (58.5%). Most of the neonates were from the weight group of 2.5 to 3 kg (26.5%). The hospital admission duration for the majority of neonates is within the 3–6-day range, accounting for 98 neonates, which represents 49% of the cases. The most prevalent reason for admission to the neonatal ICU (NICU) was preterm with respiratory distress syndrome, comprising 29% of cases, followed by neonatal sepsis at 19.5%, and preterm births at 11%. Among 423 antibiotics, the most prescribed antibiotic was injection piperacillin + tazobactam (35.4%) followed by gentamicin (30.2%). Conclusion: Empirical antibiotics were administered to every newborn based on their individual conditions. The antibiotic utilization pattern within this study group was determined to be rational.

show abstract

Prescribing Pattern of Antimicrobial Agents in Neonates at Nepalgunj Medical College, Kohalpur, Banke, Nepal

Cited by 3 publications

References 10 publications

Pattern of hospital antibiotic use in term neonates using WHO Access, Watch and Reserve Classification (AWaRe)

Pattern of hospital antibiotic use in term neonates using WHO Access, Watch and Reserve Classification (AWaRe)

Retracted: Drug Utilization Pattern of Antibiotics in Neonatal intensive care unit in a Tertiary Care Hospital, India

Drug Utilization Pattern of Antibiotics in Neonatal Intensive Care Unit at a Tertiary Care Hospital, Mysuru, Karnataka

Contact Info

Product

Resources

About