Prescribing pattern of antipsychotic drugs in the Italian general population 2000–2005: a focus on elderly with dementia

Trifirò, Gianluca; Sini, Giovanna; Sturkenboom, Miriam; Vanacore, Nicola; Mazzaglia, Giampiero; Caputi, Achille P.; Cricelli, Claudio; Brignoli, Ovidio; Aguglia, Eugenio; Biggio, G.; Samani, Fabio

doi:10.1097/yic.0b013e3283334f08

Cited by 25 publications

(26 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A population-based study found that more than 3% of community-dwelling patients are currently treated with antipsychotics in Italy, with a striking increase in the use of atypical antipsychotics over time [2•]. These findings are in accord with data from the United Kingdom [3] and United States, where olanzapine and risperidone were already the most commonly prescribed antipsychotic drugs in 1997 [4].…”

Section: Introductionmentioning

confidence: 57%

Antipsychotic Drug Use and Community-Acquired Pneumonia

Trifirò

2011

Curr Infect Dis Rep

Self Cite

View full text Add to dashboard Cite

Antipsychotics are generally distinguished as atypical and typical agents, which are indicated in the treatment of acute and chronic psychoses and other psychiatric disorders. In April 2005, the US Food and Drug Administration issued a warning about the increased risk of all-cause mortality associated with atypical antipsychotic use in elderly patients with dementia. Pneumonia was one of the most frequently reported causes of death. The same warning was extended to typical antipsychotics in June 2008. In recent years, several observational studies have further explored the association between antipsychotic use, mainly in elderly patients, and the risk of fatal/nonfatal community-acquired pneumonia. The aim of this review is to revise and discuss the scientific evidence and biologic explanations for the association between atypical and typical antipsychotic use and pneumonia occurrence. Some general recommendations to clinicians are proposed to prevent the risk of pneumonia in patients requiring antipsychotic treatment.

show abstract

Section: Introductionmentioning

confidence: 57%

Antipsychotic Drug Use and Community-Acquired Pneumonia

Trifirò

2011

Curr Infect Dis Rep

Self Cite

View full text Add to dashboard Cite

show abstract

“…Among patients 70 years and older, approximately onethird of all AP users had an indication for agitation or dementia. In a study from Italy on the basis of an Italian General Practice Database among patients 65 years and older, APs were also rarely used for schizophrenia, but more often for affective psychoses and dementia (Trifiro et al, 2010). In general, the low prevalence of schizophrenia in new AP users aged 65 years and older in our study was expected as incident cases typically occur between adolescence and the mid-30s (Holder and Wayhs, 2014).…”

Section: Indications Of Antipsychotic Usementioning

confidence: 91%

“…In Germany, 25% of older patients with dementia were treated at least once with APs in an observation period of 1 year (Schulze et al, 2013). Studies on older patients from other countries reported an AP prescription prevalence of 3-54% depending on the definition of the study population (Alanen et al, 2006(Alanen et al, , 2008Mann et al, 2009;Nijk et al, 2009;Trifiro et al, 2010;Lustenberger et al, 2011;Wetzels et al, 2011;Kruger et al, 2012;Briesacher et al, 2013;Tjia et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Treatment patterns and characteristics of older antipsychotic users in Germany

Schmedt

Jobski

Kollhorst

et al. 2016

International Clinical Psychopharmacology

View full text Add to dashboard Cite

The aim of this study was to investigate the characteristics and treatment patterns of older antipsychotic (AP) users in Germany. We carried out a cohort study in the German Pharmacoepidemiological Research Database and identified new AP users aged at least 65 years between 2005 and 2011. Possible indications, comedication, and information on persistence and adherence, concurrent multiple use, and switch of APs were assessed. Overall, 298,847 individuals were included in the cohort. Almost 70% entered the cohort with a typical antipsychotic (TAP). Melperone (23.4%) was used most frequently, followed by promethazine (18.3%), sulpiride (11.0%), and risperidone (10.3%). AP users had a low prevalence of schizophrenia and bipolar disorders in contrast to dementia. Initiators of atypical antipsychotics had more treatment episodes compared with TAPs (median 3 vs. 2), but lower median persistence (14 vs. 22 days). Persistence was also lower in patients with, rather than without, dementia. The overall percentage of concurrent multiple use and switch to other APs was low with 5.6%, but higher in patients with, rather than without, dementia. In conclusion, APs were used for a broad range of indications, mostly other than schizophrenia and bipolar disorders. Low persistence and a high number of treatment episodes suggest frequent 'as-needed' treatment, especially in dementia patients.

show abstract

“…We found that 1.06% (2004) to 1.54% (2014) of the HK population were prescribed at least 1 APD and that there was a statistically significant change in prevalence. In comparison, the annual prevalence of APD prescribing in patients from GP settings in Italy was reported as having increased from 1.33% (2000) to 1.74% (2005) . Using a community population sample from the Clinical Practice Research Datalink database in the UK, the prescribing prevalence of APDs and medication used for treating mania was reported as 1.0% and 1.4% in males and females, respectively, in 2010.…”

Section: Discussionmentioning

confidence: 99%

Prescribing trends and indications of antipsychotic medication in Hong Kong from 2004 to 2014: General and vulnerable patient groups

Lao

Tam

Wong

et al. 2017

Pharmacoepidemiology and Drug

View full text Add to dashboard Cite

(250 words)Purpose Antipsychotic prescribing patterns remain unclear in Asia. The aims of our study were to investigate prescribing trends of antipsychotic medication in the general population, children, and older patients by drug generation (first or second), the prescribing trend in pregnant women, the probable indication for antipsychotic prescription, and the prescribing trend by dosage form. Over the study period, the prevalence of antipsychotic prescribing increased from 1.06% to 1.54% in the general population, from 0.10% to 0.23% in children (3-17 years old), and from 2.61% to 3.26% in older patients (≥65 years old). The prevalence of second-generation antipsychotics increased but the prevalence of first-generation antipsychotics did not. Prevalence of antipsychotic prescribing in pre-pregnancy, pregnancy, and postpartum timeframes varied from 0.18% to 0.38%. The percentage of incident prescriptions with a diagnosis of psychosis decreased from 54.1% to 47.5%. MethodsConclusions Antipsychotics have been increasingly prescribed in the general population, children, and older patients. There is an increase in second-generation antipsychotic prescribing.Over half of incident users had a recent diagnosis of a non-psychotic mental disorder in 2014, suggesting that off-label prescribing of antipsychotics might be common.

show abstract

Prescribing pattern of antipsychotic drugs in the Italian general population 2000–2005: a focus on elderly with dementia

Cited by 25 publications

References 21 publications

Antipsychotic Drug Use and Community-Acquired Pneumonia

Antipsychotic Drug Use and Community-Acquired Pneumonia

Treatment patterns and characteristics of older antipsychotic users in Germany

Prescribing trends and indications of antipsychotic medication in Hong Kong from 2004 to 2014: General and vulnerable patient groups

Contact Info

Product

Resources

About