Prescribing patterns of psychotropic medications and clinical features in patients with major depressive disorder with and without comorbid dysthymia in China

Feng, Yuan; Sha, Sha; Hu, Chen; Wang, Gang; Ungvári, Gábor S.; Chiu, Helen F.K.; Ng, Chee H.; Tian, Mei; Chen, Da Fang; Fang, Yi; Zheng, Lirong; Yang, Hai Chen; Hu, Jianguo; Chen, Zhi Yu; Huang, Yi; Sun, Jing; Wang, Xiaoping; Li, Hui Chun; Zhang, Jin Bei; Xiang, Yu‐Tao

doi:10.1111/appy.12261

Cited by 1 publication

(1 citation statement)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the concordance of the CANMAT algorithm with naturalistic antidepressant treatment patterns in China has not been studied yet. Although previous studies reported the prescribing patterns of MDD in China ( Zhang et al, 2016 ; Chen et al, 2017 ; Feng et al, 2017 ), the longitudinal characteristics from initial pharmacotherapy to subsequent optimized treatment have not been described. Understanding the longitudinal prescription patterns especially optimized treatment strategies after the failure of monotherapy represents the first step to identify the gap between the CANMAT algorithm and real-world practice.…”

Section: Introductionmentioning

confidence: 99%

Concordance of the treatment patterns for major depressive disorders between the Canadian Network for Mood and Anxiety Treatments (CANMAT) algorithm and real-world practice in China

Yang

Dong³

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

Background: Antidepressant (AD) algorithm is an important tool to support treatment decision-making and improve management of major depressive disorder (MDD). However, little is known about its concordance with real-world practice. This study aimed to assess the concordance between the longitudinal treatment patterns and AD algorithm recommended by a clinical practice guideline in China.Methods: Data were obtained from the electronic medical records of Shanghai Mental Health Center (SMHC), one of the largest mental health institutions in China. We examined the concordance between clinical practice and the Canadian Network for Mood and Anxiety Treatments (CANMAT) algorithm among a cohort composed of 19,955 MDD patients. The longitudinal characteristics of treatment regimen and duration were described to identify the specific inconsistencies. Demographics and health utilizations of the algorithm-concordant and -discordant subgroups with optimized treatment were measured separately.Results: The overall proportion of algorithm-concordant treatment significantly increased from 84.45% to 86.03% during the year of 2015–2017. Among the patients who received recommended first-line drugs with subsequent optimized treatment (n = 2977), the concordance proportion was 27.24%. Mirtazapine and trazodone were the most used drugs for adjunctive strategy. Inadequate or extended duration before optimized treatment are common inconsistency. The median length of follow-up for algorithm-concordant (n = 811) and algorithm-discordant patients (n = 2166) were 153 days (Q1-Q3 = 79–328) and 368 days (Q1-Q3 = 181–577) respectively, and the average number of clinical visits per person-year was 13.07 and 13.08 respectively.Conclusion: Gap existed between clinical practice and AD algorithm. Improved access to evidence-based treatment is required, especially for optimized strategies during outpatient follow-up.

show abstract

Section: Introductionmentioning

confidence: 99%

Concordance of the treatment patterns for major depressive disorders between the Canadian Network for Mood and Anxiety Treatments (CANMAT) algorithm and real-world practice in China

Yang

Dong³

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

Prescribing patterns of psychotropic medications and clinical features in patients with major depressive disorder with and without comorbid dysthymia in China

Abstract: There are important differences in the demographic and clinical features of comorbid dysthymia in Chinese MDD patients compared with previous reports. The clinical profile found in this study has implications for treatment decisions.

Cited by 1 publication

References 20 publications

Concordance of the treatment patterns for major depressive disorders between the Canadian Network for Mood and Anxiety Treatments (CANMAT) algorithm and real-world practice in China

Concordance of the treatment patterns for major depressive disorders between the Canadian Network for Mood and Anxiety Treatments (CANMAT) algorithm and real-world practice in China

Contact Info

Product

Resources

About