Prescribing practices in Southeastern Europe – focus on benzodiazepine prescription at discharge from nine university psychiatric hospitals

Maric, Nadja P.; Latas, Milan; Petrović, Sanja; Soldatović, Ivan; Arsova, Slavica; Crnković, Danijel; Gugleta, Dragoslava D.; Ivezic, A.; Janjić, Vladimir; Karlović, Dalibor; Toševski, Dušica Lečić; Mihaljević-Peleš, Alma; Novotni, Antoni; Pejušković, Bojana; Radmanović, Branimir; Mladenovic, D. Siladji; Slavkovic, Violeta M.; Štimac, Zoran; Žikić, Olivera

doi:10.1016/j.psychres.2017.09.059

Cited by 23 publications

(30 citation statements)

References 29 publications

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“…This is consistent with a New Zealand study that found that 16% of psychiatric inpatients with benzodiazepine treatment also received zopiclone treatment . It is also consistent with a study conducted in southern Europe that found the simultaneous use of 2 benzodiazepines in 22% of patients prescribed benzodiazepines . The concomitant use of several benzodiazepines was associated with the occurrence of psychotic symptoms.…”

Section: Discussionsupporting

confidence: 90%

“…An excessive dosage was not frequent in patients exposed to anxiolytic and the dosage was often reduced before discharge. In a previous study conducted in southern Europe, almost 3/4 of benzodiazepine treatments had a dosage higher than recommended . That study found that an excessive dosage was more frequent in patients living alone or presenting with alcohol or substance use disorders.…”

Section: Discussionmentioning

confidence: 90%

“…In a F I G U R E 1 Dosage of benzodiazepine treatment at discharge from hospital in comparison with the maximum dosage during the hospitalisation in patients who were prescribed benzodiazepine at least once during the hospitalisation previous study conducted in southern Europe, almost 3/4 of benzodiazepine treatments had a dosage higher than recommended. 33 That study found that an excessive dosage was more frequent in patients living alone or presenting with alcohol or substance use disorders. In the present study, it was associated with alcohol or substance use disorders and with older age.…”

Section: Discussionmentioning

confidence: 96%

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Misuse of benzodiazepines: Prevalence and impact in an inpatient population with psychiatric disorders

Panes

Verdoux

Fourrier‐Réglat

et al. 2020

Brit J Clinical Pharma

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Aims Use and misuse of benzodiazepine might be very prevalent in patients with acute psychiatric symptoms, whereas they might be associated with specific adverse events in this population. The study investigated their prevalence in these patients. Secondary objectives were to identify risk factors for misuse of benzodiazepines, and its impact. Methods A cohort study was based on the hospital's electronic patient records and conducted in patients aged 18 years and over and admitted to a psychiatric hospital. They were followed up for 84 days or until the end of hospitalisation. Four variables of misuse were built: excessive duration of treatment, type of product, excessive dosage and concomitant benzodiazepines. Backward stepwise multivariate logistic regression analysis was used to assess risk factors for each misuse criterion, on the 1 hand, and impact of benzodiazepine misuse, on the other. Results In total, 511 psychiatric inpatients were included with 89.0% of them exposed to benzodiazepine. Discharge prescription included no benzodiazepine or a dosage lower than the maximum dosage prescribed during hospitalisation for 78.2% of patients exposed to benzodiazepine during their stay. Of benzodiazepine treatments, 31.4% were associated with at least 1 misuse criterion. Excessive dosage was associated with age ≥65 years (OR 11.57; 95% confidence interval 4.92–27.17), substance/alcohol use disorders (3.35; 95% confidence interval 1.70–6.62) and parenthood (0.49; 0.25–0.97). Some criteria of benzodiazepine misuse were associated with a higher frequency of adverse events occurring after treatment initiation. Conclusions Misuse of benzodiazepines is very common in inpatients with psychiatric disorders. These findings should alert clinicians to comply with clinical recommendations.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 96%

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Misuse of benzodiazepines: Prevalence and impact in an inpatient population with psychiatric disorders

Panes

Verdoux

Fourrier‐Réglat

et al. 2020

Brit J Clinical Pharma

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“…Higher daily doses and concomitant use of other DIM are also consistent with available evidence (Haw and Stubbs, 2007; Maric et al, 2017). It is well know that the amount consumed and poly-substance use are related to an increased risk of being involved in a fatal road accident (Barbone et al, 1998; Orriols et al, 2011; Schulze et al, 2012; Rudisill et al, 2014).…”

Section: Discussionsupporting

confidence: 84%

“…Importantly, mental and behavioral disorders are important risk factors to become daily benzodiazepine user, for the need of higher doses, and concomitant use of other DIM (Maric et al, 2017). Accordingly, appropriate prescription of these medicines is very important.…”

Section: Discussionmentioning

confidence: 99%

The Problem of Benzodiazepine Use and Its Extent in the Driver Population: A Population-Based Registry Study

et al. 2018

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Background: Benzodiazepines are driving-impairing medicines (DIM). This study presents current consumption of dispensed benzodiazepines in the Spanish general population, with a focus in pattern of use and concomitant medicines consumed with.Methods: A population-based registry study was carried out to assess the year-2016 granted benzodiazepines dispensation in Castile and León. Weighting was performed to obtain the adjusted benzodiazepine consumption for licensed drivers according to age and gender using our national drivers' license census data.Results: Benzodiazepines were used by 15.38% of the general population and 10.97% of drivers. Nearly 2% of the population and more than 1% of drivers took these medicines every day. The amount consumed (until 3 or more benzodiazepines per day) and concomitant use of other DIM were also higher. Women were the most frequent consumers, and anxiolytic use was usual. Consumption increases with age, but there were differences between men and women drivers from 60 years old.Conclusions: The current use of benzodiazepines must serve to awareness of the healthcare personnel, patients, and authorities on their risks, above all on the road safety.

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Incidence of and Characteristics Associated With Long-term Benzodiazepine Use in Finland

et al. 2020

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Prescribing practices in Southeastern Europe – focus on benzodiazepine prescription at discharge from nine university psychiatric hospitals

Cited by 23 publications

References 29 publications

Misuse of benzodiazepines: Prevalence and impact in an inpatient population with psychiatric disorders

Misuse of benzodiazepines: Prevalence and impact in an inpatient population with psychiatric disorders

The Problem of Benzodiazepine Use and Its Extent in the Driver Population: A Population-Based Registry Study

Incidence of and Characteristics Associated With Long-term Benzodiazepine Use in Finland

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