Prescribing the right therapy for the treatment of chronic cough: a critical focus on current and investigational options

Rogliani, Paola; Page, Clive; Calzetta, Luigino

doi:10.1080/14656566.2022.2047646

Cited by 1 publication

(1 citation statement)

References 22 publications

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“…Thus, measurement of blood CK-MB activity serves as an index for early diagnosis of AMI, and it is of great significance in judging the extent of myocardial infarction and post-infarction reperfusion [12]. Changes in LDH content in serum are used as important and sensitive markers of myocardial damage, and the selectivity of serum LDH diagnosis is second only to those of CK-MB [13]. The serum activities of CK-MB, LDH and AST in model group were higher than the corresponding sham group levels, but their serum activities in the quaternary amine group were markedly reduced, relative to the levels in model rats.…”

Section: Discussionmentioning

confidence: 99%

Quaternary amines exert anti-myocardial ischemia effects via regulation of energy metabolism and oxygen free radicals in myocardial cells in acute myocardial infarction rats

Zhang¹,

Zhang²,

Wang³

2022

Trop. J. Pharm Res

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Purpose: To investigate the effect of quaternary amines on myocardial cells of a rat model of cardiac arrest, with respect to energy generation potential and oxygen free radicals. Methods: Forty-five Sprague-Dawley (SD) rats were assigned to sham, model and quaternary amine groups (each with 15 rats). After their corresponding treatments, lectrocardiogram (ECG) monitoring of the rats in the three groups at various time periods was carried out. Serum levels of myocardial enzymes, thromboxane B2 (TXB2), prostacyclin I2 (PGI2), serum carbon monoxide (CO), and changes in endothelial carbon monoxide synthase (eNOS) and endothelin (ET), were determined. Results: The levels of NO and eNOS were significantly reduced in model rats, relative to sham operation rats, while ET was significantly elevated in sham rats (p < 0.05). There were higher levels of NO and eNOS in the quaternary amine group than in model rats, but ET was higher in quaternary amine group than in model rats. Thromboxane B2 (TXB2) concentration was higher in model rats than in sham rats (p < 0.05). While PGI2 was markedly lower in quaternary group than in sham operation rats. TXB2 was lower in the quaternary amine group than in model rats, while PGI2 was significantly higher in quaternary amine group, relative to model rats (p < 0.05). Conclusion: Quaternary amines exert anti-myocardial effects by regulating energy metabolism and oxygen free radicals in myocardial cells of congestive heart failure rats, and thus are potentially useful for the management of acute myocardial infarction. Keywords: Quaternary amine; Acute myocardial infarction; Electrocardiogram; Serum myocardial enzymes; Myocardial cells

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Section: Discussionmentioning

confidence: 99%