Prescription drug use during pregnancy in developed countries: a systematic review

Daw, Jamie R.; Hanley, Gillian E.; Greyson, Devon; Morgan, Steven G.

doi:10.1002/pds.2184

Cited by 208 publications

(194 citation statements)

References 24 publications

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“…Quanto às categorias de risco do uso de medicamentos segundo o FDA, o maior consumo foi das classes A, B e C. Elas são representadas por medicamentos para distúrbios do funcionamento gastrointestinal e preparações antianêmicas 17 . A classe A é a mais utilizada na gravidez, conforme evidenciado em uma revisão sistemática realizada por Daw et al 31 que apresentou maior consumo dessa classe em alguns países como França e Alemanha.…”

Section: Discussionunclassified

Uso de medicamentos no primeiro trimestre de gravidez: avaliação da segurança dos medicamentos e uso de ácido fólico e sulfato ferroso

Lunardi-Maia¹,

Schuelter-Trevisol²,

Galato³

2014

Rev. Bras. Ginecol. Obstet.

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Houve diferença entre as proporções de medicamentos utilizados segundo a ATC, e os principais grupos anatômicos identificados foram os dos medicamentos que atuam no sangue e órgãos hematopoiéticos e anti-infecciosos de uso sistêmico. Na época do diagnóstico da gravidez, observou-se expressivo uso de medicamentos que atuam no sistema geniturinário e hormônios sexuais (16,2%), como anticoncepcionais orais, o que provavelmente está relacionado ao percentual de gestações não planejadas (67,0%), nessa mesma ocasião 4 gestantes utilizaram ácido fólico e 3 utilizaram o sulfato ferroso. CONCLUSÃO: Os resultados demonstram uso expressivo de medicamentos durante a gravidez. Mesmo que haja menor exposição aos medicamentos no momento do diagnóstico da gravidez, observa-se maior consumo de medicamentos de risco e da prática de automedicação nesse período. Abstract PURPOSE:To identify the profile of use of medication during the first trimester of pregnancy with emphasis on safety assessment and on the adoption of folic acid and ferrous sulfate by pregnant women attended at a Basic Health Unit in Brazil. METHODS: This was a cross-sectional study nested in a cohort of pregnant women. Medications were classified according to the Anatomical Therapeutic Chemical (ATC), and their safety was evaluated according to the Food and Drug Administration (FDA) and the Brazilian Health Surveillance Agency (ANVISA). The adoption of ferrous sulfate and folic acid was investigated according to the protocol set forth by the Brazilian Ministry of Health. RESULTS: The survey included 212 pregnant women, 46.7% of whom were taking medications at the time of pregnancy diagnosis, and 97.6% used medication during the first trimester after diagnosis. The highest percentage of self-medication occurred before the beginning of prenatal care (64.9%). According to the FDA criteria, there was a high level of exposure to D and X risk drugs before the beginning of prenatal care (23.0%), which was also observed for drugs not recommended by ANVISA (36.5%). Of the surveyed sample, 32.5% did not follow the protocol of the Brazilian Ministry of Health. In all, 67.9% of pregnant women had inadequate drug exposure. There was a difference between the proportions of

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Section: Discussionunclassified

Uso de medicamentos no primeiro trimestre de gravidez: avaliação da segurança dos medicamentos e uso de ácido fólico e sulfato ferroso

Lunardi-Maia¹,

Schuelter-Trevisol²,

Galato³

2014

Rev. Bras. Ginecol. Obstet.

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“…According to literature, a recent systematic review of drug utilization studies showed a wide variation of drug use during pregnancy in developed countries, which was from 27 to 93% (Daw et al, 2011). The prevalence of medication use among pregnant women in Brazil varied from 80 to 94.6% (Brum et al, 2011;Fonseca et al, 2002;Geib et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

“…(Daw et al, 2011;Mitchell et al, 2011). Before the disaster caused by the use of thalidomide in the late 1950s and early 1960s, placenta was considered a barrier capable of protecting the fetus from any pharmacological damage (Lenz, 1962;Martinez-Frias et al, 2012;Oliveira et al, 1999;Papaseita et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of medication use among low risk pregnant women: A drug utilization study

Fontoura¹,

Ayres²,

Martins-Nagai³

et al. 2014

Afr. J. Pharm. Pharmacol.

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This study aimed to characterize the profile of medication consumption by low risk pregnant women and to correlate it with sociodemographic characteristics of this population. A cross-sectional descriptive study was conducted in the Reference Center of Women's Health in the Brazilian municipality of Ribeirão Preto. This study included women which were at least in the 32nd week of the gestation period. Data related to sociodemographic characteristics of the pregnant women and to their pregnancy and medication consumption were collected from June, 2008 to November, 2008. A total of 699 pregnant women were included. About 20% of the pregnant women began prenatal care in the 12th week of gestation and 75.3% had at least six antenatal visits. The use of at least one drug during pregnancy was reported by 98% of the participants. The mean number of medications used was 4.35. According to the Food and Drug Administration (FDA) risk classification, 14.07% of the medication belonged to C category, 1.85% to D and 0.03% to X, and 38.30% were not identified or not classified by the FDA. When correlating the number of prenatal visits with the amount of medication used, it was verified that pregnant women who underwent less than six visits during pregnancy used a higher number of medications. Pregnant women have been exposed to a variety of medications and there is a need to improve the quality of care in order to prevent potential risks to the fetus, especially in relation to the use of medications.

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“…Almost all categories of drugs are prescribed during pregnancy depending on the illness. [8][9][10][11] Mashayekhi et al have evaluated the awareness among pregnant women with regard to effect of drugs on fetus. 12 Drug use behavior in pregnant women in rural India has been investigated.…”

Section: Introductionmentioning

confidence: 99%

A study to assess awareness amongst pregnant women about the effects of drugs on the fetus and self-medication

Banzal

Saxena

Dalal

et al. 2017

Int J Basic Clin Pharmacol

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Background: The present study was conducted with an objective to assess the awareness of drug use in pregnancy, to assess the knowledge of pregnant women on effect of drugs on foetus and to assess the self-medication among pregnant women.Methods: This was a prospective, observational, cross-sectional study conducted on randomly selected 200 pregnant women attending a tertiary care hospital in Surat, Gujarat, India. Data was collected by means of a pre-designed semi-structured questionnaire composed of 26 questions on self-medication during pregnancy and knowledge about that. The data was collected by interview technique in which each participant was asked questions in the language of her understanding in a separate room.Results: The average age of the participants was 23.7±3.68 years. About 91% were not aware about the effect of medication on the health of foetus and did not even enquire about it. At the time of survey, 74% pregnant women were on some kind of medication. More than 80% were not aware about the duration of medication. About 51% were taking medication on regular basis. The proportion of self-medication among pregnant women was 8.5% (includes 5.5% by themselves and 3% by advice of chemists).Conclusions: There is a lack of awareness amongst the pregnant women regarding the effect of the drugs on the health of foetus. More than half of the women take medication on regular basis. However, low proportion of self-medication during pregnancy suggests that during pregnancy women preferred to take advise of physician for medication rather than taking self-medication.

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Prescription drug use during pregnancy in developed countries: a systematic review

Cited by 208 publications

References 24 publications

Uso de medicamentos no primeiro trimestre de gravidez: avaliação da segurança dos medicamentos e uso de ácido fólico e sulfato ferroso

Uso de medicamentos no primeiro trimestre de gravidez: avaliação da segurança dos medicamentos e uso de ácido fólico e sulfato ferroso

Prevalence of medication use among low risk pregnant women: A drug utilization study

A study to assess awareness amongst pregnant women about the effects of drugs on the fetus and self-medication

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