Prescription of Drugs to Pregnant Women in France: the HIMAGE Study

Beyens, Marie-Noëlle; Guy, Claire; Ratrema, M.; Ollagnier, M.

doi:10.2515/therapie:2003082

Cited by 49 publications

(39 citation statements)

References 19 publications

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“…[21] According to the HIMAGE study from France, 4.6% of women were exposed to drugs (mainly NSAIDs), involved in risk during pregnancy. [22] In a study from Bratislava and Nitra, it was reported that a vast majority of prescribed drugs during pregnancy, belonged to category-C. [23] In the present study, use of OTC (over the counter) drugs as self medication, was reported significantly more in graduates than in undergraduates; as well as more in the higher economic class, than in the lower. Earlier also, in a study from USA, OTC medications (e.g., ibuprofen) that are contraindicated in pregnancy, were used at unexpectedly high rates during pregnancy.…”

Section: Discussionmentioning

confidence: 56%

Drug utilization pattern during pregnancy in North India

Sharma¹,

Kapoor²,

Verma³

2006

Indian J Med Sci

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BACKGROUND: Pregnancy is a special physiological condition, where drug treatment presents a special concern. AIMS: To evaluate the drug utilization pattern during pregnancy and to evaluate the effect of the educational and economic status on it.. DESIGN: The retrospective cross-sectional study. SETTING: The postgraduate Department of Pharmacology and Therapeutics of a medical college. and the antenatal clinic of the institution. MATERIALS AND METHODS: Medical students filled 405 questionnaires after interviewing pregnant women (243 primigravida and 152 multigravida). All the collected questionnaires were analysed for various study parameters. STATISTICAL ANALYSIS USED: Inter-group comparison was done using chi-square test. P value <0.05 was considered statistically significant. RESULTS: A total of 700, 1086 and 686 drugs, with an average of 1.73, 2.89 and 2.49 drugs per pregnant women, were used during first, second and third trimester of pregnancy, respectively. A majority of the drugs used, were from category-A, followed by category-B and category-D. However, category C and X drugs constituted 2.90 (20) and 5.71% (40) of drugs used during the third trimester and first trimester, respectively. Herbal/ homeopathic drugs constituted 6.42 (45), 3.68 (40) and 1.46% (10) of the drugs used in the first, second and third trimester of pregnancy, respectively (P=649). 33.33% (135) women believed that drug use during pregnancy is dangerous to both mother and child and 37.03% (150) believed that drugs are dangerous throughout pregnancy. 55.55% (225) females advocated the use of iron/folic acid during pregnancy. 24.69% (100) of women had knowledge about barrier contraceptives. Self-medication and homeopathic/ herbal drugs use was found more in graduates than in undergraduates; as well as, it was more in the higher socioeconomic group than the lower socioeconomic group. CONCLUSION: There is a need to educate and counsel women of child-bearing age, regarding the advantages and disadvantages of drug use during pregnancies, with special reference to alternative therapies and self-medication.

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Section: Discussionmentioning

confidence: 56%

Drug utilization pattern during pregnancy in North India

Sharma¹,

Kapoor²,

Verma³

2006

Indian J Med Sci

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“…Proper prescribing demands that such contraindications do not occur but the use of such drugs may be considered in cases where benefits outweigh the risk. 20 Majority of drugs prescribed were in category B of the FDA's classification of medicines according to risk to the fetus, which is higher than the Addis Ababa study, followed by those in category C. However drugs in A and D were also obtained.…”

Section: Discussionmentioning

confidence: 74%

Untitled

2013

IJPSR

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ABSTRACT:Background: Rational drug use in pregnancy requires the benefits and potential risk associated with the use of the drug. The adverse effect of drugs on the fetus varies temporarily with time. The fetus susceptibility to injury depends on its period of development of different organs have different critical periods through the span from gestational day 15 to day 60 is critical for many organs. Objective: To assess the pattern of drug use among pregnant women in Adama Referral Hospital, Oromia region, Ethiopia. Methods: All drug prescriptions of pregnant women prescribed from December 1, 2011 to May 30 2011 were reviewed retrospectively using structured data collection format. Result: A total of 381 pregnant women prescriptions were included in the study. The average maternal age in the study was 26.74 years. A total of 176(24.44%), 336(46.66%) and 208(28.88%) drugs with an average 2.2, 1.13 and 1.83 per pregnant women were used in first, second and third trimesters respectively. Minerals and vitamins 209(29%) were the most frequently prescribed drugs followed by Antibiotics 173(24%) and analgesics 149(20.7%). Majority of the drugs were prescribed from risk category B 449(62.4%) followed by risk category C 131(18.2%) and risk category A 98(13.6%). 37(5.13%) of the drugs were received from risk category D. Conclusion: Gastrointestinal infection occurred most frequently followed by genitor-urinary tract infections. Vitamins, minerals, paracetamol and amoxicillin were most frequently prescribed drugs. The average number of drugs per prescription was comparable with a standard set by WHO, indicating that poly pharmacy was not practiced. The occurrence of contraindicated medicines was desirably low.

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“…According to the HIMAGE study from France, 4.6% of women were exposed to drugs (mainly NSAIDs), involved in risk during pregnancy 32 .…”

Section: Main Findings Of the Studymentioning

confidence: 99%

“…The studies conducted in developed countries where drug-prescribing practices are considered to be superior, have identified need for interventional measures aimed at rational prescribing during the prenatal period 16,17 .…”

mentioning

confidence: 99%

Prescription Pattern of Drugs in Pregnancy: A Review

Fatima¹,

Fatima²,

Hasbeen³

et al. 2015

Int. Res. J. Pharm.

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Authors carried out a systematic review of peer-reviewed literature published from [2005][2006][2007][2008][2009][2010][2011][2012][2013][2014]. We incorporated studies assessing individual-level exposures to medicines prescribed during pregnancy. We selected only those studies conducted in India and published in English. Published drug utilization studies reveal about 22% to 69.8% overall use of prescribed drugs during pregnancy excluding vitamins and minerals. On measuring antenatal drug use, the medications with positive evidence of risk (FDA category D) ranged from 4.8% to 24.25%. Iron, folic acid and vitamin supplements were most commonly prescribed drugs globally depending on the need of the patient and their benefit ratio. Overall drug use estimates are examined, use of drugs by therapeutic categories and by potential for fetal risk is considered while updating this review. Several studies consistently reported the usage of drugs with potential risks during pregnancy. Due to such extensive use, it is essential to develop standards for assessing and reporting antenatal exposures to refine any future research in this field. The prescribing practices of Indian physicians are similar to those in developed countries.

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Prescription of Drugs to Pregnant Women in France: the HIMAGE Study

Cited by 49 publications

References 19 publications

Drug utilization pattern during pregnancy in North India

Drug utilization pattern during pregnancy in North India

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Prescription Pattern of Drugs in Pregnancy: A Review

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