Prescription quality of prolonged antibiotherapy in pediatrics. Impact of ASP program interventions

Melendo, Susana; Fernández-Polo, Aurora; Asens, Ivette Castellnou; Mendoza-Palomar, Natàlia; Barnés-Mayolas, Meritxell; Soler‐Palacín, Pere

doi:10.1016/j.eimce.2020.02.013

Cited by 2 publications

(3 citation statements)

References 11 publications

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“…Our study also revealed an association between antibiotic treatment records and appropriate prescribing, confirming the importance of having comprehensive clinical records in improving the quality of antibiotic prescriptions. In a recent publication, we reported that the PROA-NEN program also reduced the rate of unnecessarily prolonged antibiotic treatments [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Five-Year Evaluation of the PROA-NEN Pediatric Antimicrobial Stewardship Program in a Spanish Tertiary Hospital

Fernández-Polo,

Melendo-Perez,

Larrosa Escartin

et al. 2024

Antibiotics

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Introduction: Actions to reduce and optimize antimicrobial use are crucial in the management of infectious diseases to counteract the emergence of short- and long-term resistance. This is particularly important for pediatric patients due to the increasing incidence of serious infections caused by resistant bacteria in this population. The aim of this study was to evaluate the impact of a pediatric antimicrobial stewardship program (PROA-NEN) implemented in a Spanish tertiary hospital by assessing the use of systemic antimicrobials, clinical indicators, antimicrobial resistance, and costs. Methods: In this quasi-experimental, single-center study, we included pediatric patients (0–18 years) admitted to specialized pediatric medical and surgical units, as well as pediatric and neonatal intensive care units, from January 2015 to December 2019. The impact of the PROA-NEN program was assessed using process (consumption trends and prescription quality) and outcome indicators (clinical and microbiological). Antibiotic prescription quality was determined using quarterly point prevalence cross-sectional analyses. Results: Total antimicrobial consumption decreased during the initial three years of the PROA-NEN program, followed by a slight rebound in 2019. This decrease was particularly evident in intensive care and surgical units. Antibiotic use, according to the WHO Access, Watch and Reserve (AWaRe) classification, remained stable during the study period. The overall rate of appropriate prescription was 83.2%, with a significant increase over the study period. Clinical indicators did not substantially change over the study period. Direct antimicrobial expenses decreased by 27.3% from 2015 to 2019. Conclusions: The PROA-NEN program was associated with reduced antimicrobial consumption, improved appropriate use, and decreased costs without compromising clinical and/or microbiological outcomes in patients.

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Section: Discussionmentioning

confidence: 99%

Five-Year Evaluation of the PROA-NEN Pediatric Antimicrobial Stewardship Program in a Spanish Tertiary Hospital

Fernández-Polo,

Melendo-Perez,

Larrosa Escartin

et al. 2024

Antibiotics

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“…In pediatric populations, infectious diseases are among the main causes of hospitalization and consultation, and antibiotics are the main therapeutic option in primary and hospital care [2,8]. The specific features of infectious diseases in pediatric patients, and the differences in the efficacy and safety of antimicrobials in this population with respect to adults, have contributed to the significant increase in PROA designed for children in recent years [2,[9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

“…Several studies have evaluated the implementation and development of pediatric antimicrobial stewardship programs, above all in the US [19][20][21][22]. In Spain, information on the current state of pediatric PROA is scarce, both at national and at regional level [10,14,15,19]. The objective of this study is to assess the current status of pediatric PROA in the network of hospitals belonging to the VINCat pediatric PROA group, outlining the resources available for their implementation and development and describing the various activities carried out.…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Plans to Optimize Antimicrobial Use in the Pediatric Population in Catalan Hospitals: The VINCat Pediatric PROA SHARP Survey

et al. 2023

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In Spain, many programs have been introduced in recent years to optimize antimicrobial stewardship in pediatric care (known as pediatric PROA). However, information on the current situation of these programs is scarce. The present study assesses current antimicrobial use in pediatric care in the hospitals of Catalonia affiliated with the VINCat pediatric PROA group. Between December 2020 and January 2021, an electronic survey related to the design and use of PROA was administered to members of PROA teams in our hospital network. The survey was conducted at 26 hospitals. Twelve percent of the hospitals had pediatric PROA in operation, 42% were included in adult PROA, and 46% carried out pediatric PROA activities but not as part of an established program. At 81%, the pediatric PROA team included a pediatrician, in 58% a pharmacist, and in 54% a microbiologist. The main activities were monitoring the use of antimicrobials and bacterial resistance. Twenty-seven percent measured indicators regularly. The VINCat Pediatric PROA group’s hospitals have implemented measures for optimizing antimicrobial stewardship, but few have a pediatric PROA program in place. Specific measures and indicators must be defined, and the resources available should be increased. The development of pediatric PROA should be monitored in the coming years.

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Prescription quality of prolonged antibiotherapy in pediatrics. Impact of ASP program interventions

Cited by 2 publications

References 11 publications

Five-Year Evaluation of the PROA-NEN Pediatric Antimicrobial Stewardship Program in a Spanish Tertiary Hospital

Five-Year Evaluation of the PROA-NEN Pediatric Antimicrobial Stewardship Program in a Spanish Tertiary Hospital

Assessment of the Plans to Optimize Antimicrobial Use in the Pediatric Population in Catalan Hospitals: The VINCat Pediatric PROA SHARP Survey

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