Presence and distribution of leucocyte subsets in the murine epididymis after vasectomy

Nashan, Dorothée; Cooper, Trevor G.; Knuth, Ulrich A.; Schubeus, P.; Sorg, Clemens; Nieschlag, Eberhard

doi:10.1111/j.1365-2605.1990.tb00958.x

Cited by 34 publications

(24 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These changes in vasectomized mice were considered indicative of chronic inflammation and increased antigen presentation (Nashan et al, 1990). Whereas definition of functional subsets of leukocytes by staining with antibodies has not yet been accomplished in vasectomized Lewis rats, it is notable that the present ultrastructural observations also identified features of chronic inflammation and revealed many opportunities for presentation of antigens to lymphocytes by macrophages.…”

Section: Cells Of the Lnfersfifial Reactionsmentioning

confidence: 74%

“…We have directed attention to the occurrence of inflammatory lesions in epididymal interstitial tissue after vasectomy in the Lewis rat (Flickinger et al, 1990a), and postvasectomy epididymal inflammation has also been described recently in the mouse (Nashan et al, 1990). These reactions are characterized by accumulation of mononuclear cells in the connective tissue, and the presence of an interstitial reaction is correlated with higher serum antisperm antibody levels (Flickinger et al, 1990a).…”

Section: Flammation Ratmentioning

confidence: 94%

“…antigen-positive cells were the major cell types, and there was recruitment of T-helperhnducer lymphocytes (Nashan et al, 1990). These changes in vasectomized mice were considered indicative of chronic inflammation and increased antigen presentation (Nashan et al, 1990).…”

Section: Cells Of the Lnfersfifial Reactionsmentioning

confidence: 98%

See 2 more Smart Citations

Ultrastructure of epididymal interstitial reactions following vasectomy and vasovasostomy

et al. 1993

View full text Add to dashboard Cite

The response of the male reproductive tract to vasectomy includes inflammation of the interstitial tissue of the epididymis. The pathogenesis of epididymal interstitial reactions and characteristics of the responding cells were studied by electron microscopy in Lewis rats at intervals following bilateral vasectomy, vasectomy followed 1 month later by vasovasostomy, or sham operations. In areas of interstitial reaction, numerous macrophages, monocytes, lymphocytes, neutrophils, and plasma cells occupied the connective tissue. Macrophages, containing many lysosomes and vesicles, aggregated and assumed the appearance of epithelioid cells. Processes of adjacent macrophages interdigitated with one another and closely approached the surfaces of lymphocytes. Many plasma cells with distended rough endoplasmic reticulum appeared in the interstitium. The majority of animals in the vasectomy and vasovasostomy groups exhibited epididymal interstitial changes by 2-3 months; the cauda epididymidis was the region most often affected. The ultrastructural features were indicative of chronic granulomatous inflammation and were consistent with an immune response that includes antigen presentation by macrophages to lymphocytes, lymphocyte differentiation, and local antibody production by plasma cells. The nearly complete absence of sperm or recognizable parts thereof in the interstitial tissue in the areas of the reactions suggests that these lesions formed in response to soluble antigens leaking from the duct. Vasovasostomy was not effective in reversing or retarding epididymal inflammation at the intervals studied.

show abstract

Section: Cells Of the Lnfersfifial Reactionsmentioning

confidence: 74%

Section: Flammation Ratmentioning

confidence: 94%

See 1 more Smart Citation

Ultrastructure of epididymal interstitial reactions following vasectomy and vasovasostomy

et al. 1993

View full text Add to dashboard Cite

show abstract

“…The origin of leukocytes from the epididymis has been confirmed by studies performed using the vasectomy model,3637 and these models produce evidence of local inflammatory responses following the procedure. However, in patients with leukocytospermia, seminal citric acid concentrations (a marker of prostate function) appear to be lower, which suggests that prostatitis is the main cause of the presence of leukocytes in the semen.…”

Section: Discussionmentioning

confidence: 92%

Male accessory gland inflammation prevalence in type 2 diabetic patients with symptoms possibly reflecting autonomic neuropathy

et al. 2014

View full text Add to dashboard Cite

Male accessory gland inflammation or infection (MAGI) is a potentially underdiagnosed complication of type 2 diabetes (DM2); specifically, we reported in a recent study that the frequency of MAGI was 43% among DM2 patients. In previous studies, we have demonstrated that diabetic autonomic neuropathy (DAN) is associated with a peculiar ultrasound characterization of the seminal vesicles (SVs) in DM2 patients. The aim of the present study was to evaluate the frequency of MAGI in two different categories of DM2 patients (i.e. patients with and without symptoms that possibly reflect DAN) and the respective ultrasound characterizations. Sixty DM2 patients with a mean (± s.e.m.) age of 42.0 ± 6.0 years (range: 34–47 years) were classified according to the presence or the absence of symptoms that could possibly reflect DAN (group A: DM2 with symptoms possibly reflecting DAN, n = 28 patients and group B: DM2 without symptoms possibly reflecting DAN, n = 32 patients). The patients in Group A exhibited a significantly higher frequency of MAGI compared with those in group B patients (P < 0.05); moreover, the Group A patients exhibited a significantly higher frequency of ultrasound signs suggestive of vesiculitis (P < 0.05). Finally, the concentrations of lymphocytes but not the concentrations of the leukocytes in the semen were significantly higher (P < 0.05) in group A compared with group B.

show abstract

“…Epididymal basal lamina was thickened, interstitial collagen became abundant and inflammatory lesions were observed in the tunica propria surrounding the tubules following vasectomy (Nashan et aL , 1990;Flickinger et al , 1990). In the present study, while there no epithelial alterations in the ipsilateral epididymis 3 months after vasectomy, collagen accumulation was seen in the interstitial tissue.…”

Section: Discussionmentioning

confidence: 46%

Comparison of the Effects of Vasectomy and Experimental Cryptorchidism in Rats

Yücel

Onarlıoğlu

Eray

et al. 1998

Okajimas Folia Anatomica Japonica

View full text Add to dashboard Cite

Summary: Vasectomy is a male contraception method that its side effects and reversibility rate are still controversial. Effects of vasectomy on epididymal morphology and function, which plays a crucial role in sperm maturation and storage, have not yet fully described. Therefore the present study was planned to find out the effects of vasectomy on epididymal structure, and comparisons of these effects were also made with the effects of a persistent infertility model, experimental cryptorchidism.To do this, 15 male Swiss albino rats were divided into 3 groups. While 5 animals were sham -operated, the rest were undergone either vasectomy (5 rats) or experimental cryptorchidism (5 rats) procedures. Epididymal tissue samples were collected prepared for light microscopy. Tissue sections were stained using appropriate staining techniques and evaluated under the light microscope.While there were distinct alterations in the epididymal morphology following experimental cryptorchidism, vasectomized rat epididymal features seemed similar to those seen in the sham -operated group. In conclusion, it could be suggested that the vasectomy might be a convenient method for male contraception.

show abstract

Presence and distribution of leucocyte subsets in the murine epididymis after vasectomy

Cited by 34 publications

References 22 publications

Ultrastructure of epididymal interstitial reactions following vasectomy and vasovasostomy

Ultrastructure of epididymal interstitial reactions following vasectomy and vasovasostomy

Male accessory gland inflammation prevalence in type 2 diabetic patients with symptoms possibly reflecting autonomic neuropathy

Comparison of the Effects of Vasectomy and Experimental Cryptorchidism in Rats

Contact Info

Product

Resources

About