Presence in Mali of<i>Leishmania major</i>MON-26

Izri, M. A.; Doumbo, Ogobara K.; Belazzoug, S; Pratlong, Francine

doi:10.1051/parasite/1989646510

Cited by 14 publications

(15 citation statements)

References 2 publications

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“…Thus, other Leishmania species may exist in Mali, but they seem to be rarely observed in the geographic areas where L. major was found. Along with three previous reports confirming the presence of L. major in Mali, [7][8][9] this study suggests that L. major is likely the sole species responsible for CL in Mali and that it is found throughout the country.…”

mentioning

confidence: 68%

“…Before 2009, L. major had been isolated from two skin lesions, one from a visitor to Mali and the other from a Malian. 7,8 A more recent study identified four different L. major strains in Mali. 9 Although these reports established the presence of L. major in the country, the frequency of specific etiologic agents and the extent of their geographical distribution in Mali remain unknown.…”

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confidence: 99%

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Leishmania major, the Predominant Leishmania Species Responsible for Cutaneous Leishmaniasis in Mali

Paz

Samake²,

Anderson³

et al. 2013

The American Society of Tropical Medicine and Hygiene

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Abstract. Leishmania major is the only species of Leishmania known to cause cutaneous leishmanisis (CL) in Mali. We amplified Leishmania DNA stored on archived Giemsa-stained dermal scraping slides obtained from self-referral patients with clinically suspected CL seen in the Center National d'Appui A La Lutte Contre La Maladie (CNAM) in Bamako, Mali, to determine if any other Leishmania species were responsible for CL in Mali and evaluate its geographic distribution. Polymerase chain reaction (PCR) amplification was performed using a Leishmania species-specific primer pair that can amplify DNA from L. major, L. tropica, L. infantum, and L. donovani parasites, possible causative agents of CL in Mali. L. major was the only species detected in 41 microscopically confirmed cases of CL from five regions of Mali (Kayes, Koulikoro, Sé gou, Mopti, and Tombouctou). These results implicate L. major as the predominant, possibly exclusive species responsible for CL in Mali.

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confidence: 68%

mentioning

confidence: 99%

Leishmania major, the Predominant Leishmania Species Responsible for Cutaneous Leishmaniasis in Mali

Paz

Samake²,

Anderson³

et al. 2013

The American Society of Tropical Medicine and Hygiene

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“…However, the zymodeme found in Burkina Faso was different from that from Mali and Senegal (Izri et al 1989 …”

Section: Leishmaniasis In West Africamentioning

confidence: 94%

“…In the West African region, CL is caused by L. major and has been reported from reservoir hosts, vectors and human patients from The Gambia, Senegal, Burkina Faso and Mali (Dedet et al 1981(Dedet et al , 1982Izri et al 1989;Harrat et al 1998). Cutaneous leishmaniasis is proposed to be endemic in a belt running from Mauritania, Gambia and Senegal in the west to Nigeria and Cameroon in the east.…”

Section: Leishmaniasis In West Africamentioning

confidence: 99%

Leishmaniasis in northern and western Africa: a review

Kimutai¹,

Ngure²,

Tonui³

et al. 2010

African Journal of Infectious Diseases

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Leishmaniasis, one of the highly neglected diseases is currently a significant health problem in northern Africa with a rising concern in western Africa because of co-infection with the Human Immunodeficiency Virus (HIV). In this review, we present a summarized analysis of the epidemiology, infective species, parasites reservoirs, diagnosis, treatment and control measures of leishmaniasis in northern and western Africa region. In northern Africa, the disease is prevalent in Morocco, Algeria, Tunisia, Egypt and Libya. Comparatively, there are low prevalence rates of the disease in West African countries including Cameroon, Ghana, Burkina Faso, Niger, Mali, Nigeria and Senegal. In North Africa, visceral leishmaniasis (VL) is caused by L. infantum and transmitted by Phlebotomus perniciosus and P. longicuspis. On the other hand, cutaneous leishmaniasis (CL) is mainly caused by L. major and transmitted by P. papatasi, P. duboscqi and P. pedifer with L. infantum and L. tropica causing lower incidences of the disease. Notably, Algeria is one of the countries that constitute 90% of CL cases worldwide. In Western Africa; CL is caused by L. major while VL is caused by L. donovani. In these regions, zoonotic and anthroponotic cutaneous and visceral leishmaniasis is a health problem that should be addressed urgently.

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“…Depuis 1958, la leishmaniose cutanée (LC) a été rapportée au Mali [16] ; en 1989 les zymodèmes MON-25 et MON-26 de Leishmania major ont été identifiés chez deux patientes [10,13]. Deux autres zymodèmes : MON-17 et MON-117 y ont ensuite été décrits [24].…”

Section: Introductionunclassified

Épidémiologie clinique et parasitologique de la leishmaniose cutanée dans cinq villages du Pays Dogon, Mali

Koné

Delaunay

Djimdé

et al. 2012

Bull. Soc. Pathol. Exot.

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The epidemiology of the cutaneous leishmaniasis (CL) with Leishmania major is poorly documented in Mali. Following reports of CL in the tourist areas of the Dogon country (Bandiagara Escarpment), a joint French and Malian bio-clinical team conducted a field study from 16 to 27 January, 2010. The population of 5 villages has been examined by a dermato-infectiologist and cases were selected by visual inspection of skin lesions. Smears and biopsies (from the lesions) and venous blood were obtained from suspected cases of CL. Diagnosis was performed by light microscopy, in vitro cultures, serology and molecular biology. Fifty patients with skin lesions have been examined. Twenty-one have been suspected as CL. At least one sample was obtained from 18 patients. The lesions were predominantly old, more or less scarring and secondary infected. A skin smear was performed for 15 patients, a skin biopsy for 14 patients: smears and cultures were all negative. The PCR (Leishmania spp.) made on 14 biopsies was positive for 12 patients (86%). The low amount of amplified DNA obtained did not allow the sequencing and identification of the species of Leishmania. Western blot (WB) serology was positive in 11 cases out of 12 (92%). This investigation showed the presence of cutaneous leishmaniasis in Bandiagara. A further investigation is required during transmission period (September-October) to confirm the presence of Leishmania major epidemic in Dogon country.

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Presence in Mali ofLeishmania majorMON-26

Cited by 14 publications

References 2 publications

Leishmania major, the Predominant Leishmania Species Responsible for Cutaneous Leishmaniasis in Mali

Leishmania major, the Predominant Leishmania Species Responsible for Cutaneous Leishmaniasis in Mali

Leishmaniasis in northern and western Africa: a review

Épidémiologie clinique et parasitologique de la leishmaniose cutanée dans cinq villages du Pays Dogon, Mali

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