Presence of a biomaterial implant facilitates induction of experimental infective endocarditis due to streptococci and staphylococci

Zaat, Sebastian A. J.; Dankert, J.; Werff, J.W. van der; Brokke, P.; Feijén, Jan

doi:10.1007/bf00134316

Cited by 1 publication

(3 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Even in a low susceptibility IE rabbit model [24], where the catheter was removed before challenge with 10 5 cfu of strain J30, vaccination enhanced the susceptibility for IE. The enhanced susceptibility to IE of the vaccinated rabbits was not due to an increased adherence to or growth of VS at the vegetations, nor were the magnitude and duration of bacteremia or the size of the vegetations different in vaccinated and nonvaccinated rabbits.…”

Section: Discussionmentioning

confidence: 99%

“…After another 24 h, these rabbits received the bacterial inoculum. In the latter model, rabbits are less susceptible to IE [14,22,24,33].…”

Section: Methodsmentioning

confidence: 99%

“…Rabbits from which the catheter was removed were challenged with 10 5 cfu of the test organisms 24 h after catheter removal. Such inocula induce low frequencies (10%-20%) of IE in the respective models [3,17,24] and should allow for accurate measurement of differences in rabbit susceptibility to IE development. Rabbits were killed by intravenous injection of pentobarbitone at 5 min or 48 h after challenge with the test organisms.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Platelet Microbicidal Activity Is an Important Defense Factor against Viridans Streptococcal Endocarditis

Dankert

Krijgsveld

Werff³

et al. 2001

J INFECT DIS

View full text Add to dashboard Cite

To study the role of platelet microbicidal activity in host defense against infective endocarditis (IE) due to viridans streptococci (VS), the susceptibility to platelet releasate of blood and oral VS isolates from patients with and without IE was compared. The influence of neutralization of platelet microbicidal activity was studied in 2 experimental IE models. Resistance to platelet releasate was more prevalent among VS from blood of patients with IE than from blood of bacteremic patients without IE and among oral VS isolates. Serum from rabbits vaccinated with human platelet sonicate supernatants neutralized human and rabbit platelet-released microbicidal activity and had antibodies recognizing microbicidal proteins thrombocidin-1 and -2 and other human platelet proteins. In the 2 rabbit IE models, vaccination increased the susceptibility to experimental IE due to platelet releasate-susceptible VS. Thus, platelet-released microbicidal activity is an important host defense factor against IE due to VS.

show abstract

Section: Discussionmentioning

confidence: 99%

“…After another 24 h, these rabbits received the bacterial inoculum. In the latter model, rabbits are less susceptible to IE [14,22,24,33].…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation