Presence of an expressed ?-tubulin gene (TUBB) in the HLA class I region may provide the genetic basis for HLA-linked microtubule dysfunction

Volz, Armin; Weiß, Elisabeth H.; Trowsdale, John; Ziegler, Andreas

doi:10.1007/bf00218911

Cited by 20 publications

(7 citation statements)

References 20 publications

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“…Whilst the P3B locus does not itself encode a protein, a novel member of a multiple copy gene family which codes for polypeptide sequences distinct from class I has previously been mapped in close proximity to it [21]. Recently, a gene coding for a putative GTPbinding protein HSR1 as well as tubulin-B have also mapped close to HLA-E and the P3B locus [22,23]. The HLA-E locus is less than 100 kb telomeric of P3B ( Fig.…”

Section: Resultsmentioning

confidence: 99%

A new marker in the HLA class I region is associated with the age at onset of IDDM

Demaine¹,

Hibberd²,

Mangles³

et al. 1995

Diabetologia

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Summary The (MHC) class II association with insulin-dependent diabetes mellitus (IDDM) is well documented. However, it is likely that genes within the MHC class III and the class I region also play a role in determining susceptibility to IDDM. In this study we have used a novel molecular probe to investigate the class I P3A and P3B loci of 179 patients with IDDM and 142 normal control subjects. A highly significant increase in the frequency of the class I P3 4.0;1.5 kilobase (kb) and 4.0;1.8;1.5 kb genotypes was found in patients compared to the control subjects (22 46.8, 6 dr, p < 0.0001). The association with the P3B 1.5 kb allele was strongly associated with the age at onset of diabetes, being present in 96.2 % of subjects who developed diabetes between the age of 10-20 years compared to 55.0 and 74.6 % who developed diabetes before 10 years or after 20 years, respectively (2 2 31.4, p < 0.0001). There was no evidence for linkage disequilibrium between the DQA1 and DQB1 loci and P3B suggesting that this is an independent association. In conclusion, these results suggest that genes in both the MHC class I and II regions confer susceptibility to IDDM and are related to the age at onset of the disease. [Diabetologia (1995) 38: 623-628]

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Section: Resultsmentioning

confidence: 99%

A new marker in the HLA class I region is associated with the age at onset of IDDM

Demaine¹,

Hibberd²,

Mangles³

et al. 1995

Diabetologia

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“…Studies have demonstrated that tubulin is a target site for a number of antitumor drugs, among which β-tubulin has seven species of isomers and its coding genes are located in 6p21.3 (1). According to the combined detection with isoelectric focusing and mass spectrometry, β-tubulin-III has been recognized as the only marker with a resistance to a microtubule drug among the seven species of isomers.…”

Section: Introductionmentioning

confidence: 99%

Correlation between microtubule-associated gene expression and chemosensitivity of patients with stage II non-small cell lung cancer

Jiang¹,

Xiao-fang³

et al. 2013

Experimental and Therapeutic Medicine

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The aim of this study was to explore the correlation between mRNA expression of β-tubulin-III and stathmin in patients with stage II non-small cell lung cancer (NSCLC) and the chemosensitivity to Navelbine plus cisplatin (NP), as well as to provide a basis for personalized treatment. A single-gene quantitative test was performed to detect the mRNA expression of β-tubulin-III and stathmin in the tumor tissue of patients with stage II NSCLC. All the patients underwent NP treatment following surgery and were followed-up to record their disease-free survival (DFS) and overall survival (OS). Statistical analyses were conducted to investigate the correlation between β-tubulin-III and stathmin mRNA expression and DFS and OS in the patients. β-tubulin-III mRNA expression was associated with OS in the 73 patients (P=0.003) and DFS was correlated with β-tubulin-III mRNA expression and lymphatic metastasis (P<0.01). Stathmin mRNA expression was not correlated with OS or DFS (P>0.05). OS and DFS were longer in the patients with low β-tubulin-III mRNA expression than in those with high β-tubulin-III mRNA expression (P<0.01); there was no significant change in OS and DFS between the patients with high and low mRNA expression of stathmin (P>0.05). The mRNA expression levels of β-tubulin-III in the tumor tissue of patients with stage II NSCLC may be considered as an index of prognosis and chemosensitivity, as well as a reference for personalized chemotherapeutic applications in patients.

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“…Third, there is the case of chromosome 7 uniparental disomy and other chromosomal anomalies with KS-like symptoms, summarized in the letter by Pan et al (1998). PCD candidates on other chromosomes include the following: (1) the HLA region of chromosome 6p, containing the btubulin gene (TUBB) (Volz et al 1994), although limited data reported elsewhere (Gasparini et al 1994) did not support the motylin gene (MLN), also residing in this region, as being a candidate for involvement in PCD etiology; (2) chromosome 14q32, containing the gene for echinoderm microtubule-associated protein (EMAP), a candidate for Usher syndrome type 1A (the USH1A gene) (these patients exhibit, in the axonemes of their respiratory cilia ultrastructural defects similar to those in PCD) (Bonneau et al 1993;Eudy et al 1997); (3) the dynein heavy-chain gene located on 14qter (Narayan et al 1994a); and (4) numerous other dynein, nexin, and other microtubule-related genes rapidly accumulating in the genomics databases. Many genes have been implicated recently in the control of the left-right asymmetry of body development such as that observed in KS (Overbeek 1997;Srivastava 1997;Wood 1997;Levin and Mercola 1998).…”

Section: Figurementioning

confidence: 99%

Cancer Genetics and Insurance

Niermeijer

1999

The American Journal of Human Genetics

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Presence of an expressed ?-tubulin gene (TUBB) in the HLA class I region may provide the genetic basis for HLA-linked microtubule dysfunction

Cited by 20 publications

References 20 publications

A new marker in the HLA class I region is associated with the age at onset of IDDM

A new marker in the HLA class I region is associated with the age at onset of IDDM

Correlation between microtubule-associated gene expression and chemosensitivity of patients with stage II non-small cell lung cancer

Cancer Genetics and Insurance

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