Presence of Antideoxyribonucleic Acid Antibody in Patients with Hyperthyroidism of Graves’ Disease*

Abstract

In 16 untreated patients with hyperthyroidism due to Graves' disease, serum antidouble stranded DNA antibody, measured by RIA, was positive (greater than 20 U/ml) in 14. In methimazole-treated patients with T3-suppressible thyroid uptake, anti-DNA antibody was found in 9% (3 of 35). The frequency of positive tests in methimazole-treated patients with T3-nonsuppressible thyroid uptake and in surgically treated patients was 24% (5 of 21) and 57% (4 of 7), respectively. Among anti-DNA antibody-negative (less than 9 U/ml) and weakly positive (10-19 U/ml) patients, those with T3-suppressible thyroid uptake had lower anti-DNA antibody titers than those with T3-nonsuppressible thyroid uptake. Among 32 patients with Hashimoto's thyroiditis, anti-DNA antibody was positive in 7. None of the patients with simple goiter had positive or weakly positive anti-DNA antibody results. Although the quantity of antibodies did not correlate well in individual patients, the rates of positive TSH binding-inhibiting immunoglobulin and anti-DNA antibody tests were roughly comparable in these patient groups. None of these patients with thyroid disease associated with anti-DNA antibody had clinical or other serological evidence suggestive of systemic lupus erythematosus or related collagen vascular disorders. The finding of anti-DNA antibody provides a new aspect of immunological abnormality associated with hyperthyroidism of Graves' disease.

Generation of recombinant, enzymatically active human thyroid peroxidase and its recognition by antibodies in the sera of patients with Hashimoto's thyroiditis.

“…Antibodies against a number of thyroid antigens are present in the sera of these patients, including thyroglobulin and the thyroid microsomal antigen (3,4). Other antigens of lesser or uncertain importance include the second colloid antigen (3), tubulin (5), DNA (6), and au-toimmune thyroid disease-related antigen I (7). Antibodies against the microsomal antigen, which is expressed on the cell surface (8,9), are believed to be of greater importance than those against thyroglobulin in the pathogenesis ofHashimoto's thyroiditis.…”

Presença de auto-anticorpos não-tireóide-específicos no soro de pacientes com hipotireoidismo auto-imune

“…Resultados do ANA/HA versus controles Tabela (16) Kohno et al (14) verificaram que, apesar de pacientes com LES apresentarem maior incidência de anti-TPO positivo quando comparados a um grupo de controles saudáveis, este anti-TPO teria uma diferença qualitativa (menor capacidade de inibir a atividade da TPO) em relação ao presente no soro de pacientes com TH (14), o que é relevante quando se avalia associação entre LES e doenças da tireóide. Por outro lado, pacientes com Dait tratados apresentam menor incidência de auto-anticorpo anti-DNA positivo quando em comparação com pacientes com Dait ainda não-tratados (12), o que pode significar uma exacerbação temporária do sistema auto-imune.…”

“…Por outro lado, anticorpos contra componentes não-específicos da tireóide também foram encontrados no soro de pacientes com tireoidite auto-imune (1,6,12,13,17,19,25).…”

Autoimmune Aspects of Primary Pulmonary Hypertension

“…It is well acknowledged that thyroid dysfunction may be at tributed to autoimmune processes. Thyroid disorders have been reported in conjunction with systemic lupus erythematosus, progressive systemic sclerosis and Sjo gren's syndrome [24][25][26], Elevated anti-DNA antibodies were described among patients with thyroid dysfunctions [27,28]. These connections lead us to a conclusion that autoimmune thyroiditis and PPH might have a common autoimmune extraction.…”