Presence of BRCA1 and BRCA2 proteins in human milk fat globules after delivery

Vissac, Cécile; Lémery, D.; Corre, Ludovic Le; Fustier, Pierre; Déchelotte, P.; Maurizis, Jean‐Claude; Bignon, Yves Jean; Bernard‐Gallon, Dominique

doi:10.1016/s0925-4439(01)00085-0

Cited by 21 publications

(12 citation statements)

References 20 publications

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“…We displayed the specificity of the anti-BRCA1 and anti-BRCA2 polyclonal antibodies by competition with the synthetic peptides used to generate the antibodies. A complete displacement of the equilibrium was obtained in each case demonstrating the specificity of the antibodies (data not shown) (Hizel et al, 1999;Vissac et al, 2001Vissac et al, , 2002.…”

Section: Discussionmentioning

confidence: 78%

Resveratrol increases BRCA1 and BRCA2 mRNA expression in breast tumour cell lines

et al. 2003

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The phytochemical resveratrol, found in grapes, berries and peanuts, has been found to possess cancer chemopreventive effects by inhibiting diverse cellular events associated with tumour initiation, promotion and progression. Resveratrol is also a phyto-oestrogen, binds to and activates oestrogen receptors that regulate the transcription of oestrogen-responsive target genes such as the breast cancer susceptibility genes BRCA1 and BRCA2. We investigated the effects of resveratrol on BRCA1 and BRCA2 expression in human breast cancer cell lines (MCF7, HBL 100 and MDA-MB 231) using quantitative real-time RT -PCR, and by perfusion chromatography of the proteins. All cell lines were treated with 30 mM resveratrol. The expressions of BRCA1 and BRCA2 mRNAs were increased although no change in the expression of the proteins were found. These data indicate that resveratrol at 30 mM can increase expression of genes involved in the aggressiveness of human breast tumour cell lines.

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Section: Discussionmentioning

confidence: 78%

Resveratrol increases BRCA1 and BRCA2 mRNA expression in breast tumour cell lines

et al. 2003

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“…Furthermore, they demonstrated the presence of the onco-suppressor BRCA1 protein in bovine and human MFGM (Spitsberg & Gorewit, 1998). Vissak et al (2002) detected BRCA1 and BRCA2 in extracts obtained from human and bovine MFGM using affinity chromatography. Both the BRCA2 and BRCA1 proteins are involved in DNA repair processes, although BRCA2 has an additional function as one of the direct regulators of cytokinesis (Daniels, Wang, Lee, & Venkitaraman, 2004).…”

Section: Phospholipidsmentioning

confidence: 99%

Nutritional and technological aspects of milk fat globule membrane material

Dewettinck

Rombaut

Thienpont

et al. 2008

International Dairy Journal

487

424

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“…Interestingly, some authors [7,58] have demonstrated the presence of the onco-suppressors breast related cancer antigens 1/2 (BRCA1 and BRCA2) in human and bovine MFGM. These two onco-suppressors are involved in DNA repair processes [7].…”

Section: Major Mfgm Proteinsmentioning

confidence: 99%

Comparative Proteomics of Milk Fat Globule Membrane (MFGM) Proteome across Species and Lactation Stages and the Potentials of MFGM Fractions in Infant Formula Preparation

Manoni

Lorenzo

Ottoboni

et al. 2020

Foods

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Milk is a lipid-in-water emulsion with a primary role in the nutrition of newborns. Milk fat globules (MFGs) are a mixture of proteins and lipids with nutraceutical properties related to the milk fat globule membrane (MFGM), which protects them, thus preventing their coalescence. Human and bovine MFGM proteomes have been extensively characterized in terms of their formation, maturation, and composition. Here, we review the most recent comparative proteomic analyses of MFGM proteome, above all from humans and bovines, but also from other species. The major MFGM proteins are found in all the MFGM proteomes of the different species, although there are variations in protein expression levels and molecular functions across species and lactation stages. Given the similarities between the human and bovine MFGM and the bioactive properties of MFGM components, several attempts have been made to supplement infant formulas (IFs), mainly with polar lipid fractions of bovine MFGM and to a lesser extent with protein fractions. The aim is thus to narrow the gap between human breast milk and cow-based IFs. Despite the few attempts made to date, supplementation with MFGM proteins seems promising as MFGM lipid supplementation. A deeper understanding of MFGM proteomes should lead to better results.

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Presence of BRCA1 and BRCA2 proteins in human milk fat globules after delivery

Cited by 21 publications

References 20 publications

Resveratrol increases BRCA1 and BRCA2 mRNA expression in breast tumour cell lines

Resveratrol increases BRCA1 and BRCA2 mRNA expression in breast tumour cell lines

Nutritional and technological aspects of milk fat globule membrane material

Comparative Proteomics of Milk Fat Globule Membrane (MFGM) Proteome across Species and Lactation Stages and the Potentials of MFGM Fractions in Infant Formula Preparation

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