1994
DOI: 10.1016/s0344-0338(11)80704-1
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Presence of Cytomegalovirus Genome and Leucocyte Subsets in Renal Transplant Biopsies

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Cited by 4 publications
(3 citation statements)
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“…We and others have shown previously that predomi nantly vascular rejections are less frequent in patients treated with CsA than in patients treated with azathio prine [15,22,39], In the present series, vascular rejection seems to be unrelated to intrarenal levels of CsA, as 75% of the cases with this type of rejection had high levels of CsA. This situation is the opposite of that observed in purely interstitial rejections which occurred in cases with low intrarenal CsA levels.…”
Section: Discussioncontrasting
confidence: 56%
See 1 more Smart Citation
“…We and others have shown previously that predomi nantly vascular rejections are less frequent in patients treated with CsA than in patients treated with azathio prine [15,22,39], In the present series, vascular rejection seems to be unrelated to intrarenal levels of CsA, as 75% of the cases with this type of rejection had high levels of CsA. This situation is the opposite of that observed in purely interstitial rejections which occurred in cases with low intrarenal CsA levels.…”
Section: Discussioncontrasting
confidence: 56%
“…Intrarenal determinations of leukocyte subsets along with the observation of characteristic morphological le sions are useful tools in the diagnosis of rejection in post transplant renal biopsy specimens [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15]. Fluctuations in serum levels of ciclosporin A (CsA) may influence the trig gering of acute rejection; however, few studies have attempted to relate intrarenal CsA levels to the type of A preliminar)' report of these findings was given at the Accepted: l st Congreso Iberoamericano de Nefrologia and published J une 24, 1994 in abstract form: Nefrologia 1992:12:156. leukocyte subsets that lead to histological lesions [ 16], Ini tial evidence has already been reported that suggests the existence of CsA-and steroid-resistant rejection crises in cardiac and lung allograft recipients under treatment with CsA [17,18]; the crises were linked with the overexpres sion of multidrug resistance related glycoprotein p-170 by CD4 lymphocytes and/or macrophages.…”
Section: Introductionmentioning
confidence: 99%
“…However, much controversial data have been published. The majority of investigators regard acute rejection as a risk factor for CMV reactivation and not vice versa [48]. In contrast, CMV is blamed for the onset of chronic rejection reflected by obliterative arteriopathy, probably due to upregulation of cytokine expression, although the coincidence with CMV strongly varies between heart, liver and kidney transplants.…”
Section: Localized CMV Manifestation (Graft Injury)mentioning
confidence: 99%