Presence of detectable levels of soluble HLA-G molecules in CSF of relapsing–remitting multiple sclerosis: relationship with CSF soluble HLA-I and IL-10 concentrations and MRI findings

Fainardi, Enrico; Rizzo, Roberta; Melchiorri, Loredana; Vaghi, Luca; Castellazzi, Massimiliano; Marzola, Andrea; Govoni, Vittorio; Paolino, E.; Tola, Maria Rosaria; Granieri, Enrico; Baricordi, Olavio R.

doi:10.1016/s0165-5728(03)00266-2

Cited by 78 publications

(79 citation statements)

References 60 publications

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“…In another study, the same group of investigators correlated sHLA-G levels in the CSF from MS patients with the clinical course of the disease and the results of MRI imaging in patients with RR, SP and PP MS. sHLA-G levels in CSF were significantly increased in clinically stable and MRI inactive individuals, indicating that sHLA-G mediated immunosuppression may be involved in disease stabilization. Furthermore sHLA-G and IL10 levels in the CSF from patients with RR MS were correlated with each other and were found to be increased in MS patients without lesional activity on MRI scans, suggesting the involvement of both molecules in disease remission [47].…”

Section: I) Immune-mediated Disordersmentioning

confidence: 86%

“…Furthermore, while sHLA-I serum levels were low in clinically active MS patients, sHLA-G serum levels were decreased in clinically stable MS patients. Thus, sHLA-I and sHLA-G1 display opposite trends in relation to disease activity in MS patients [47]. In another study, the same group of investigators correlated sHLA-G levels in the CSF from MS patients with the clinical course of the disease and the results of MRI imaging in patients with RR, SP and PP MS. sHLA-G levels in CSF were significantly increased in clinically stable and MRI inactive individuals, indicating that sHLA-G mediated immunosuppression may be involved in disease stabilization.…”

Section: I) Immune-mediated Disordersmentioning

confidence: 97%

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Soluble HLA-G: Are they clinically relevant?

Pistoia¹,

Morandi²,

Wang³

et al. 2007

Seminars in Cancer Biology

162

182

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HLA-G is a non-classical HLA-class Ib molecule with multiple immunoregulatory properties. Its main function in physiological conditions is to abrogate maternal NK cell activity against foetal tissue and to establish immune tolerance at maternal-foetal interface. HLA-G is expressed not only as a membrane bound molecule on the surface of cells, but also as a soluble moiety in body fluids. The major isoforms of HLA-G present in serum are soluble HLA-G1 and HLA-G5 which are generated by shedding or proteolytic cleavage of the membrane bound isoform and by secretion of a soluble isoform, respectively.Here we review the data about soluble HLA-G (sHLA-G) serum levels in different pathological conditions, including immune-mediated disorders, transplantation, and malignancies. In particular, we focus on sHLA-G expression and function in human neuroblastoma, a pediatric tumor, with special emphasis on a novel potential immuno escape mechanism utilized by NB to instruct monocytes to produce and release sHLA-G. Finally, the potential clinical relevance of sHLA-G serum levels is discussed.

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Section: I) Immune-mediated Disordersmentioning

confidence: 86%

Section: I) Immune-mediated Disordersmentioning

confidence: 97%

Soluble HLA-G: Are they clinically relevant?

Pistoia¹,

Morandi²,

Wang³

et al. 2007

Seminars in Cancer Biology

162

182

View full text Add to dashboard Cite

show abstract

“…HLA-G exhibit tolerogenic properties via interaction with inhibitory receptors presented in natural killer (NK) cells, T cells and antigen-presenting cells (APC) [28] . The presence of soluble HLA-G (sHLA-G) in the cerebrospinal fluid of multiple sclerosis [29] and allograft acceptance after transplantation [30] suggests a tolerogenic function for this molecule against innate and adaptive cellular immune responses. Interestingly, work from our lab and others have suggested that HLA-G antigens may play a protective role in inflammation [31,32] .…”

Section: Hla-g: Molecule Of Immune Tolerancementioning

confidence: 99%

New aspects in celiac disease

Torres

Casado²,

Rı́os³

2007

WJG

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“…It is well described that the extended HLA-haplotype, including the HLA-DRB1 * 01/ * 04 combination, is associated with cardiovascular disease and mortality (32). Of interest, an association between HLA-G polymorphisms and other chronic inflammatory disorders, such as inflammatory bowel disease (33,34), asthma (35,36) and multiple sclerosis (37)(38)(39), has been repeatedly reported. Besides the potential role played by HLA-G in inflammation and immunity (15), there is evidence to suggest that this molecule may also modulate endothelial cell activity (40,41).…”

Section: Discussionmentioning

confidence: 99%