Presence of Helicobacter species in bile and gallbladder as a risk factor for cholelithiasis/cholecisthitis

Queiroz, Dulciene M.; Silva, Cintia P.; Oliveira, Adriana Gonçalves; Guerra, Juliana Becattini; Marques, Daniela Lemos; Sarmanho, Letícia; Pereira-Lima, Júlio Carlos

doi:10.1016/s0016-5085(03)81236-2

Cited by 2 publications

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“…These discordant results may be due to regional differences, as pointed out by Fallone et al ., 1 especially when it is considered that gastric H. pylori infection is much greater in Brazil than in Canada and the micro‐organism may gain access to the bile by retrograde transfer from the stomach/duodenum. However, it should be noted that DNA from H. pylori has been detected consistently in biliary specimens only when a more sensitive nested polymerase chain reaction (PCR) is used, 3 , 4 as was the case in our study. The sensitivity of conventional PCR is quite low, and it is consistently positive only when the micro‐organism is present at a level of 10 3 colony‐forming units/mL or more in the sample, as confirmed by Fallone et al 1 .…”

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confidence: 53%

“…These results are in disagreement with others that have identified Helicobacter DNA in the bile or gall‐bladder tissue of patients with or without biliary diseases 2 ,. 3 In a similar study, we evaluated the presence of Helicobacter DNA in gall‐bladder tissues and bile samples from 64 Brazilian patients, and found that it was more frequently seen in those with cholelithiasis/cholecystitis 4 . The sequences of the amplified products of the 16S rRNA gene were more than 99.3% similar to that of H. pylori .…”

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confidence: 96%

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Helicobacter DNA in bile: correlation with hepato‐biliary diseases

Queiroz

Oliveira

Guerra

et al. 2003

Aliment Pharmacol Ther

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Triple vs. quadruple therapy for treating Helicobacter pylori infection: an updated meta-analysis Sirs, Since we submitted our paper, ÔTriple vs. quadruple therapy for treating Helicobacter pylori infection: a meta-analysisÕ, for publication in Alimentary Pharmacology and Therapeutics, 1 a new study comparing triple with quadruple therapy has been published. 2 Full-text reports of two of the studies included in the metaanalysis in abstract form have also been published. 3, 4 The objective of this letter is to update the meta-analysis using these new results. The report of Mantzaris et al. compares triple with quadruple therapy for H. pylori infection in patients with duodenal ulcer. 2 The authors obtained better eradication rates with triple than with quadruple therapy. However, the differences did not reach statistical significance. The results of the report by Katelaris et al. are identical to those published in abstract form, 3 whereas there are small differences between the abstract and full-text form of the paper by Laine et al. 4 The results of our meta-analysis did not change after introducing these modifications ( Figure 1). In the intention-to-treat analysis, eradication was achieved in 449 of 559 patients with quadruple therapy [80%; 95% confidence interval (CI), 77-84%] and in 451 of 569 patients with triple therapy (79%; 95% CI, 74-81%). The odds ratio (Figure 1) was 1.00 (95% CI, 0.64-1.57; P ¼ 1). In the per protocol analysis, eradication was achieved in 421 of 486 patients with quadruple therapy (87%; 95% CI, 84.1-90.5%) and in 435 of 509 patients with triple therapy (85%; 95% CI, 81.4-88.3%). The odds ratio was 0.95 (95% CI, 0.58-1.57; P ¼ 0.9).In conclusion, the update of our meta-analysis suggests that the conclusions of the previous report can be maintained, and that the effectiveness of quadruple and triple therapy is very similar for the initial treatment of H. pylori infection.E. Gené *, X. Calvet , R.

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confidence: 53%

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Helicobacter DNA in bile: correlation with hepato‐biliary diseases

Queiroz

Oliveira

Guerra

et al. 2003

Aliment Pharmacol Ther

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“…9 However, Fallone et al 13 failed to find DNA of the genus Helicobacter in the bile of Canadian patients with biliary disorders, whilst a completely contrary result was described by Queiroz et al who found bacterial nucleotidic sequences in most Brazilian subjects with similar diseases. 21 To explain these discordant findings, some factors have been invoked such as regional differences due to variable rates of infection and the changing sensitivity of the various PCR techniques used in the above reported studies. 22 Whether H. pylori participates in the pathogenesis of biliary diseases is at the moment a controversial topic.…”

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confidence: 99%

DNA sequences and proteic antigens of H. pylori in cholecystic bile and tissue of patients with gallstones

Neri

Margiotta

Francesco

et al. 2005

Aliment Pharmacol Ther

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SUMMARYBackground: Although Helicobacter pylori DNA sequences have been detected in cholecystic bile and tissue of patients with gallstones, controversial results are reported from different geographic areas. Aim: To detect H. pylori in cholecystic bile and tissue of patients with gallstones from a previously uninvestigated geographic area, southern Italy. Detection included both the bacterial DNA and the specific antigen (H. pylori stool antigen) identified in the stools of infected patients for diagnostic purposes. Patients and methods: The study enclosed 33 consecutive patients undergoing laparoscopic cholecystectomy for gallstones. DNA sequences of H. pylori were detected by polymerase chain reaction in both cholecystic bile and tissue homogenate. Moreover, we assayed H.pylori stool antigen on gall-bladder cytosolic and biliary proteins after their extraction. Bacterial presence in the stomach

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Presence of Helicobacter species in bile and gallbladder as a risk factor for cholelithiasis/cholecisthitis

Cited by 2 publications

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Helicobacter DNA in bile: correlation with hepato‐biliary diseases

Helicobacter DNA in bile: correlation with hepato‐biliary diseases

DNA sequences and proteic antigens of H. pylori in cholecystic bile and tissue of patients with gallstones

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