Presence of hepcidin-25 in biological fluids: Bile, ascitic and pleural fluids

Arnold, Jayantha; Sangwaiya, Arvind; Manglam, Vijay; Geoghegan, Frank; Thursz, Mark; Busbridge, Mark

doi:10.3748/wjg.v16.i17.2129

Cited by 15 publications

(15 citation statements)

References 24 publications

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“…Salivary metal levels are quite variable and are believed to be affected by diet [3], salivary flow rates [2], occupational exposure [4], and quantity of metal-binding salivary proteins [5]. Analyses of salivary metal content has been related to exposure to toxic metals [2,4], metal-leaching dental devices [6], or the relationship to disease states [7,8].…”

Section: Introductionmentioning

confidence: 99%

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Salivary metals, age, and gender correlate with cultivable oral Candida carriage levels

Norris

Friedman

Chen

et al. 2018

Journal of Oral Microbiology

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Background: Little is known about the normal range of metal levels in unstimulated saliva, nor whether these might impact Candida carriage in healthy individuals. Both are important in determining which populations are at risk for candidiasis, as the availability of metal ions can influence the growth and pathogenesis of Candida albicans. Objective: We quantified salivary metals of healthy individuals to determine the correlation with C. albicans oral colonization. Design: Unstimulated whole saliva was collected from healthy adults and plated to determine fungal carriage, and metal content was measured using ICP-mass spectrometry (ICP-MS). Results: Zinc was most abundant, followed by iron, copper, manganese, and nickel. Cultivable oral Candida carriage was found in 48% of people. Total protein levels did not differ in salivas from donors with or without carriage. However, innate fungicidal activity was increased in donors with carriage; correlations between levels of several metals were stronger in salivas with fungal carriage, indicating a shift in the oral environment. Concentrations of copper and manganese, as well as age and gender, were significantly predictive of carriage levels in a multiple regression model. Conclusions: Salivary copper and manganese content along with age and gender could be used as a predictive metric for individuals that are more susceptible to Candida overgrowth.

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Section: Introductionmentioning

confidence: 99%

“…Saliva contains many proteins involved in nutritional immunity [5,10,12]. Calprotectin is the classic example of a metal-sequestering protein [10] that binds manganese, zinc, and iron with nanomolar to picomolar affinity, and inhibits microbial growth by disrupting superoxide dismutase function [13,14].…”

Section: Introductionmentioning

confidence: 99%

Salivary metals, age, and gender correlate with cultivable oral Candida carriage levels

Norris

Friedman

Chen

et al. 2018

Journal of Oral Microbiology

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“…Гепсидин можно рассматривать как в качестве марке-ра воспаления, так и индикатора обмена железа. Так, например, в англоязычной научной литературе можно встретить следующие характеристики гепсидина: «iron-hormone» (железный гормон) и «antimicrobial peptide» (противомикробный белок) [53].…”

Section: растворимые рецепторы трансферринаunclassified

“…Одна-ко в случае ВЗК-ассоциированной анемии в литературе встречаются противоречивые данные о корреляционной связи гепсидина и активности ВЗК, взаимосвязи пара-метров обмена железа, маркеров воспаления и концен-трации гепсидина [55,56]. В этих исследованиях не было обнаружено четкой связи между концентрацией гепси-дина и уровнем ИЛ 6 и С-реактивного белка при том, что связь последних со степенью активности ВЗК и участие в процессах выработки гормона гепсидина были доказа-ны ранее [53,54].…”

Section: растворимые рецепторы трансферринаunclassified

Anemia in Inflammatory Bowel Diseases in Children

Олегович¹,

Потапов²,

Цимбалова³

et al. 2016

Vopr. sovr. pediatr.

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“…Hepcidin is in bile and may act along with α-defensins against gut microflora (11) . Arnold et al (12) demonstrate the presence of hepcidin in pleural and ascitic fluid with unknown biological activity. Shike et al (13) showed that in white bass liver, infection with the fish pathogen Streptococcus iniae increased hepcidin mRNA expression 4500-fold.…”

Section: Introductionmentioning

confidence: 99%

Serum and Ascitic Fluid Hepcidin in HCV Positive Liver Cirrhosis with and without HCC

Atti¹,

Dawood²,

Essa³

et al. 2013

EJPM

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Background & Aim: Chronic HCV infection suppresses hepatic hepcidin expression which may enhance iron toxicity and lead to disease progression and HCC development. The aim of the study is to investigate the role of hepcidin in HCV+ve liver cirrhosis patients in relation to disease progression and HCC development. Patients and methods: The study population consists of: 20 HCV+ve patients without HCC (HCV patients), 20 HCV+ve patients with HCC (HCV-HCC patients) and 10 controls. In addition to comprehensive clinical examination, they were subjected to laboratory check-up for albumin, bilirubin, PT %, ferritin, AFP and hepcidin. Ascitic fluid hepcidin was done for all patients. Results: There was a significant difference among HCV and HCV-HCC patients and controls with regard serum ferritin and hepcidin (P = 0.001 & 0.0001 respectively). Serum hepcidin of HCV and HCV-HCC patients were significantly lower than controls (P = 0.0001). Serum and ascitic fluid hepcidin of HCV-HCC patients was significantly lower than HCV patients (P = 0.01 & 0.02 respectively). Serum ferritin was significantly higher in HCV and HCV-HCC patients than controls (P = 0.001). Serum ferritin of HCV-HCC patients was significantly higher than HCV patients (P = 0.02). . Conclusion: Low levels of hepcidin may be involved in the pathophysiologic mechanism of iron overload in patients with chronic HCV with and without HCC. Moreover, there is a positive relationship between hepcidin levels and synthetic liver function suggesting that uniform suppression of hepcidin may be linked to disease progression and HCC development. Further analysis is still required to evaluate its usefulness as a marker for early detection of HCC by serial measurement of hepcidin in blood and ascitic fluid.

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Presence of hepcidin-25 in biological fluids: Bile, ascitic and pleural fluids

Abstract: We provide clear evidence that hepcidin-25 is present in bile, saliva, pleural and ascitic fluids. Hepcidin is likely to play a role here in innate immunity.

Cited by 15 publications

References 24 publications

Salivary metals, age, and gender correlate with cultivable oral Candida carriage levels

Salivary metals, age, and gender correlate with cultivable oral Candida carriage levels

Anemia in Inflammatory Bowel Diseases in Children

Serum and Ascitic Fluid Hepcidin in HCV Positive Liver Cirrhosis with and without HCC

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