Presence of interleukin-8 and the IL-1 receptor antagonist in the cervical mucus of fertile and infertile women

Kataranovski, Milena; Radojčić, Ljiljana; Prokić, Vera; Vojvodić, Danilo

doi:10.2298/vsp0404359k

Cited by 4 publications

(2 citation statements)

References 15 publications

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“…Mid-cycle cervical mucus adversely affected the bioactive properties of IL-4 and the immunoglobulins IgA and IgG by decreasing their recovery from aqueous media after contact [24]. Cervical mucus contains antagonists of two key inflammatory cytokines, IL-8 and IL-1, both involved in the recruitment of phagocytic and inflammatory cell types [25]. Thus mucus may regulate immune parameters in the female reproductive tract by both physical and biochemical mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Estradiol-induced vaginal mucus inhibits antigen penetration and CD8+ T cell priming in response to intravaginal immunization

Seavey¹,

Mosmann²

2009

Vaccine

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Although vaginal immunization has been explored as a strategy to induce mucosal immunity in the female reproductive tract, this site displays unique immunological features that probably evolved to inhibit anti-paternal T cell responses after insemination to allow successful pregnancy. We previously demonstrated that estradiol, which induces an estrus-like state, prevented CD8 + T cell priming during intravaginal immunization of mice. We now show that estradiol prevented antigen loading of vaginal antigen presenting cells (APC) after intravaginal immunization. Histological examination confirmed that estradiol prevented penetration of peptide antigen into the vaginal wall. Removal of the estradiolinduced mucus barrier by mucinase partially restored antigen loading of vaginal APC and CD8 + T cell proliferation in vivo. The estradiol-induced mucus barrier may thus prevent exposure to antigens delivered intravaginally, supplementing additional estradiol-dependent mechanism(s) that inhibit CD8 + T cell priming after insemination or vaginal vaccination.

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Section: Discussionmentioning

confidence: 99%

Estradiol-induced vaginal mucus inhibits antigen penetration and CD8+ T cell priming in response to intravaginal immunization

Seavey¹,

Mosmann²

2009

Vaccine

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“…When the abundance of IL6 and IL8 in the serum and cervical mucus of infertile women were compared with that of matched fertile women, a significantly higher concentration of both cytokines were found among infertile women, suggesting a probable role in the etiology of female infertility (Naz and Butler, ). Subsequent studies support this relationship, particularly for IL8 (Spandorfer et al, ; Kataranovski et al, ). Another study reported that oocyte fertilization rates in patients with endometriosis are markedly lower than those with tubal infertility (Xu et al, ), suggesting that recruitment of cytokines near or into the ovary may also impair oocyte quality.…”

Section: Cytokinesmentioning

confidence: 87%

Non‐hormonal targets underlying endometriosis: A focus on molecular mechanisms

Che

Chen

et al. 2015

Molecular Reproduction Devel

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Endometriosis is regarded as a hormone-dependent disease. Current therapeutic approaches to treating this common gynecological disorder mainly depend on surgical and hormonal interventions, but the high rate of disease recurrence as well as the side effects related to such therapies make it difficult for patients to recover completely. Molecular evidence has recently suggested that the source of endometriosis can be both hormone-dependent and influenced by the dysregulation of some signaling cascades. In this review, we focus on the non-hormonal triggers of endometriosis and the pre-clinical compounds designed to correct these signaling defects in order to achieve a better understanding of the disease as well as novel approaches to treating it.

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Chemokines in the pathogenesis of endometriosis and infertility

Borrelli¹,

Carvalho²,

Kallas³

et al. 2013

Journal of Reproductive Immunology

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Presence of interleukin-8 and the IL-1 receptor antagonist in the cervical mucus of fertile and infertile women

Abstract: Changes in IL-8 and IL-1Ra levels in the cervical mucus of infertile patients with negative postcoital test suggested the existence of the relationship between cervical cytokines and infertility in these women.

Cited by 4 publications

References 15 publications

Estradiol-induced vaginal mucus inhibits antigen penetration and CD8+ T cell priming in response to intravaginal immunization

Estradiol-induced vaginal mucus inhibits antigen penetration and CD8+ T cell priming in response to intravaginal immunization

Non‐hormonal targets underlying endometriosis: A focus on molecular mechanisms

Chemokines in the pathogenesis of endometriosis and infertility

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