Presence of Invasive Devices and Risks of Healthcare-Associated Infections and Sepsis

Abstract

The present study evaluated the daily risk of healthcare-associated infections and sepsis (HAIS) events in pediatric intensive care unit patients with invasive devices. This was a retrospective cohort study. Invasive devices were associated with significant daily risk of HAIS (p < 0.05). Endotracheal tubes posed the greatest risk of HAIS (hazard ratio [HR]: 4.39, confidence interval [CI]: 2.59–7.46). Children with both a central venous catheter (CVC) and urinary catheter (UC) had over 2.5-fold increased daily risk (HR: 2.59, CI: 1.18–5.68), in addition to daily CVC risk (HR: 3.06, CI: 1.38–6.77) and daily UC risk (HR: 8.9, CI: 3.62–21.91). We conclude that a multistate hazard model optimally predicts daily HAIS risk.

Evaluating the Potential of a New Low-Profile Urinary Catheter in Preventing Catheter-Associated Urinary Tract Infections: A Prospective Randomized Blinded Clinical Trial

“…Despite the efforts of limiting indwelling urinary catheter (IUC) insertion in determined cases and duration and fast removal, many patients still undergo urinary catheterization during their stay in the hospital, 1,2 especially comatose patients 3 in intensive care units (ICUs). [4][5][6][7] IUCs can lead to catheter-associated urinary tract infections (CAUTI) 8 in 70-80% of patients 9 within 48 h of catheterization. 1 The bacterial biofilm-based CAUTI is detected in 73.4% of patients with a mean duration of catheterization of 5.01 days.…”

“…3,13 Transurethral catheterization can also cause noninfectious complications such as urethral traumatization and hematuria. 4 To reduce urothelial damage, more attention needs to be given to the physical structure of urinary catheters. 14 To reduce the urothelium trauma resulting from the IUC structure, a bladder drainage system is designed with urine eyelets between the two balloons.…”

“…Despite the efforts of limiting indwelling urinary catheter (IUC) insertion in determined cases and duration and fast removal, many patients still undergo urinary catheterization during their stay in the hospital, 1,2 especially comatose patients 3 in intensive care units (ICUs). 4–7…”

“…3,13 Transurethral catheterization can also cause noninfectious complications such as urethral traumatization and hematuria. 4 To reduce urothelial damage, more attention needs to be given to the physical structure of urinary catheters. 14…”

Review of Minimally Invasive and Invasive MEMS Devices for Biomedical Diagnostic Applications: Design Aspects

“…Microsensor devices with larger errors might even lead to a dangerous scenario when a determination of diseased locations in the internal organ is flawed. Therefore, recent day's research focuses more on miniaturizing Piezoresistive microsensors that yield high accuracy, resolution, displacement, precision and sensitivity (3).…”