2001
DOI: 10.1016/s0024-3205(01)01143-2
|View full text |Cite
|
Sign up to set email alerts
|

Presence of melatonin in the human hepatobiliary-gastrointestinal tract

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

2
87
0
4

Year Published

2001
2001
2023
2023

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 105 publications
(93 citation statements)
references
References 0 publications
2
87
0
4
Order By: Relevance
“…However, these levels disappeared when food was restricted. Furthermore, the findings that melatonin levels were higher in the portal vein than in the systemic circulation and that the TRP-induced elevation in the portal vein occurred earlier than in the systemic circulation also demonstrated that GIT contributes significantly to circulating plasma levels of melatonin, especially during the daytime [8,54,59,71,79].…”
Section: Melatonin Synthesis and Secretionmentioning
confidence: 93%
See 2 more Smart Citations
“…However, these levels disappeared when food was restricted. Furthermore, the findings that melatonin levels were higher in the portal vein than in the systemic circulation and that the TRP-induced elevation in the portal vein occurred earlier than in the systemic circulation also demonstrated that GIT contributes significantly to circulating plasma levels of melatonin, especially during the daytime [8,54,59,71,79].…”
Section: Melatonin Synthesis and Secretionmentioning
confidence: 93%
“…Interestingly, whereas the nighttime concentrations peaked at the day 7 of the embryonic development, the daytime levels reached on that day their lowest point [53]. Phylogenetically, melatonin was identified in the GIT of fishes, reptiles, amphibians, birds and mammals, including humans [9,42,43,45,49,52,54].…”
Section: Ontogeny and Phylogenymentioning
confidence: 99%
See 1 more Smart Citation
“…With respect to the gastrointestinal tract, systemic effects may be expected, as it is released into the blood stream in response to food intake (Bubenik, 2002(Bubenik, , 2008. Due to its unique lipophilic nature (Hardeland et al 2011;Chava & Sirisha, 2012), circulating melatonin crosses the cell membranes and distributes easily into tissues and biological fluids; it occurs in milk (Cohen Engler et al 2012), bile (Messner et al 2001), cerebrospinal fluid (Tan et al 2010), urine and saliva (Vakkuri, 1985;de Almeida et al 2011;Almughrabi et al 2012).…”
Section: Introductionmentioning
confidence: 99%
“…Once synthesized, the majority of melatonin diffuses directly towards the cerebrospinal fluid of the brain's third ventricle, while another fraction is released into the blood stream where it is distributed to all tissues and body fluids (Cheung et al 2006). It is found in serum, saliva (Cutando et al 2011, Novakova et al 2011, cerebrospinal fluids (Rousseau et al 1999), and aqueous humor of the eye (Chiquet et al 2006), ovarian follicular fluid, hepatogastrointestinal tissues (Messner et al 2001). Melatonin in the milk of lactating mothers exhibits a marked daily rhythm, with high levels during the night and undetectable levels during the day (Illnerova et al 1993, Sanchez-Barcelo et al 2011.…”
Section: Synthesis Distribution and Metabolismmentioning
confidence: 99%