Presence of molluscum contagiosum virus within an epidermal cyst

Müller, Cornelia; Laue, Michael; Kremer, K; Becker, S; Vogt, Thomas; Smola, Sigrun

doi:10.1111/ddg.13633

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…Most of the articles highlight the curiosity of the picture and provide characteristic images that even integrate publications with the format of "what is your diagnosis?" [1][2][3].…”

Section: Discussionmentioning

confidence: 99%

Moluscum contagiosum on infundibular cyst. No more than a curiosity

Gómez¹,

González²,

Zambrano³

et al. 2022

JCRR

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The infundibular cyst is a skin lesion typically located on hairy areas that is extremely common. In fact, it is part of the daily routine of any pathology laboratory. Although both the dermatologist, the surgeon and the pathologist are sufficiently familiar with it and guide each case correctly, sometimes there are histological peculiarities that justify the histological study of the lesion. The coincidence of a molluscum contagiosum, a highly contagious entity in the context of an infundibular cyst, implies taking a series of precautions that would not be implemented based solely on clinical criteria.

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“…Most of the articles highlight the curiosity of the picture and provide characteristic images that even integrate publications with the format of "what is your diagnosis?" [1][2][3].…”

Section: Discussionmentioning

confidence: 99%

Moluscum contagiosum on infundibular cyst. No more than a curiosity

Gómez¹,

González²,

Zambrano³

et al. 2022

JCRR

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“…Follicular induction in the adjacent epidermis should not be mistaken for a basal cell carcinoma 86 . Four per cent of cases can be associated with another lesion such as epidermal cyst and melanocytic naevus potentially obscuring the molluscum contagiosum infection changes 87,88 . Coinfection of molluscum contagiosum virus with other infectious agents such as human papillomavirus or Cryptococcus neoformans in the same lesion, especially in immunocompromised patients, can also occur 89 …”

Section: Histopathologymentioning

confidence: 99%

2020 European guideline on the management of genital molluscum contagiosum

Edwards¹,

Boffa

Janier

et al. 2020

Acad Dermatol Venereol

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Molluscum contagiosum is a benign viral epidermal infection associated with high risk of transmission. The guideline is focused on the sexually transmitted molluscum contagiosum. The diagnosis is clinical with characteristic individual lesions, termed ‘mollusca’, seen as dome‐shaped, smooth‐surfaced, pearly, firm, skin‐coloured, pink, yellow or white papules, 2 ‐ 5 mm in diameter with central umbilication. Dermoscopy may facilitate diagnosis. Therapeutic options are numerous, including physical treatments (cautery, curettage and cryotherapy), topical chemical treatments (e.g. podophyllotoxin and imiquimod) or waiting for spontaneous resolution in immunocompetent patients. In pregnancy, it is safe to use physical procedures (e.g. cryotherapy). Immunosuppressed patients develop severe and recalcitrant molluscum lesions that may require treatment with cidofovir, imiquimod or interferon. Patients with molluscum contagiosum infection should be offered to be screened for other sexually transmitted infections.

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Diagnostic electron microscopy in human infectious diseases – Methods and applications

Laue

2024

Journal of Microscopy

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Diagnostic electron microscopy (EM) is indispensable in all cases of infectious diseases which deserve or profit from the detection of the entire pathogen (i.e. the infectious unit). The focus of its application has shifted during the last decades from routine diagnostics to diagnostics of special cases, emergencies and the investigation of disease pathogenesis. While the focus of application has changed, the methods remain more or less the same. However, since the number of cases for diagnostic EM has declined as the number of laboratories that are able to perform such investigations, the preservation of the present knowledge is important. The aim of this article is to provide a review of the methods and strategies which are useful for diagnostic EM related to infectious diseases in our days. It also addresses weaknesses as well as useful variants or extensions of established methods. The main techniques, negative staining and thin section EM, are described in detail with links to suitable protocols and more recent improvements, such as thin section EM of small volume suspensions. Sample collection, transport and conservation/inactivation are discussed. Strategies of sample examination and requirements for a proper recognition of structures are outlined. Finally, some examples for the actual application of diagnostic EM related to infectious diseases are presented. The outlook section will discuss recent trends in microscopy, such as automated object recognition by machine learning, regarding their potential in supporting diagnostic EM.

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Presence of molluscum contagiosum virus within an epidermal cyst

Cited by 3 publications

References 15 publications

Moluscum contagiosum on infundibular cyst. No more than a curiosity

Moluscum contagiosum on infundibular cyst. No more than a curiosity

2020 European guideline on the management of genital molluscum contagiosum

Diagnostic electron microscopy in human infectious diseases – Methods and applications

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