Presence of multiple human papillomavirus types in cervical samples from HIV-infected women

Levi, José Eduardo; Fernandes, Silvana; Tateno, Adriana Fumie; Motta, Eduardo Vieira da; Lima, Liliam Pereira de; Eluf-Neto, José; Pannuti, Cláudio Sérgio

doi:10.1016/j.ygyno.2003.10.004

Cited by 93 publications

(99 citation statements)

References 29 publications

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“…This observation is in accordance with a recent study of HIV (1) women in Brazil. 35 In the aforementioned study it was reported that infection with two or more oncogenic HPV types did not confer additional risk of developing cervical lesions. Interestingly, a recent study utilizing DNA chip technology found that multiple oncogenic HPV infection was associated less frequently with the severity of cervical neoplasia.…”

Section: Discussionmentioning

confidence: 96%

Cross‐sectional analysis of oncogenic HPV viral load and cervical intraepithelial neoplasia

Flores

Papenfuss

Klimecki

et al. 2005

Intl Journal of Cancer

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In human papillomavirus (HPV)-associated carcinogenesis, HPV infection characteristics such as viral load may play an important role in lesion development. The purpose of this study was to determine the association between quantitative assessment of oncogenic HPV viral load, and abnormal cytology among women residing along the United States-Mexico border. A cross-sectional study of 2,319 women was conducted between 1997 and 1998. Viral load of oncogenic HPV types (16,18,31,39, 45, 51, 52, and 58) was measured among 173 HPV (1) women using quantitative real-time PCR. Overall, HPV 16, 31, 52 and 58 showed the highest viral load. Single type infection had higher viral loads compared to multiple type infections. HPV viral load declined significantly (p 5 0.04) with age. No significant association was observed with other known HPV risk factors such as oral contraceptive use, parity, sexual and STD history. Viral load was independently associated with degree of cervical lesions. An adjusted odds ratio (AOR) of 4.7 for the association between increasing total viral load and Atypical Squamous Cells of Undetermined Significance (ASCUS)/ Atypical Glandular Cells of Undetermined Significance (AGUS) was observed (p for trend <0.01). Increased risk of low-grade SIL was observed with higher viral load compared with HPV negative women (AOR 5 47.7 for total viral load; AOR 5 37.1 for HPV viral load not including HPV16, and AOR 5 25.9 for HPV16 viral load). Likewise, increased risk of high-grade SIL with higher viral loads was observed (AOR 5 58.4 for high total viral load compared with HPV negative women, AOR 5 58.1 for HPV viral load not including HPV16, and AOR 5 69.8 for HPV16 high viral load). Results from this study suggest a dose-response relationship between increasing oncogenic HPV viral load and risk of LSIL and HSIL. ' 2005 Wiley-Liss, Inc.Key words: human papillomavirus; viral load; cervical lesions Squamous intraepithelial lesions (SIL) are the precursor lesions for the development of cervical cancer and are caused primarily by infection with human papillomavirus (HPV). Cervical cancer, however, does not occur without the persistent presence of HPV in the squamo-columnar junction. 1 Since the majority of cervical lesions regress to normal cytology after a period of 12 months from presumed first infection, it is thought that the remaining cervical lesions persist due to environmental, host and viral cofactors that have a pleiotropic effect on HPV viral replication, the immune system and tissue microenvironment. [2][3][4][5][6][7][8][9][10] Recent studies suggest that HPV16 viral load may be a possible molecular biomarker in the natural history of HPV infection. Using a semi-quantitative measure of HPV16 DNA levels, several observational studies have found a high correlation between high viral load and high-grade intra-epithelial lesions. Although a possible role for HPV16 viral load has emerged, only a few studies have used quantitative measures of viral load to study the association of distinct oncogenic HPV types a...

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Section: Discussionmentioning

confidence: 96%

Cross‐sectional analysis of oncogenic HPV viral load and cervical intraepithelial neoplasia

Flores

Papenfuss

Klimecki

et al. 2005

Intl Journal of Cancer

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“…In Ahdeich Grant et al [11,12], Hanskin's [13], Firnhasen [14], and Heard et al studies [15,16], they all said that low CD4 counts and increased HIV viral loads have an independent association with the incidence of delayed clearance of HPV infections as well as with the risk of progression of SIL (squamous intra-epithelial lesions).…”

Section: Cd4 Count and Its Association With The Colposcopic Findings mentioning

confidence: 99%

Colposcopic Study of Lower Genital Tract Infections in HIV-Positive Women on Antiretroviral Therapy

Badkur

Ghanghoriya

2016

J Obstet Gynecol India

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Aims and Objectives To study the colposcopic findings and prevalence of lower genital tract infections in HIVpositive women on anti-retroviral therapy. To find correlation between colposcopic finding, m RNA HPV and cytology of lower genital tract infections in HIV-positive women on anti-retroviral therapy. Materials and Methods The present prospective observational study was conducted in the Department of Obstetrics and Gynaecology, Netaji Subhash Chandra Bose Medical College, Jabalpur, from 1 June 2013 to 31 October 2014. The data of the present study was recorded into computer and after proper validation, error checking, coding and decoding, the data was compiled and analysed using the SPSS Windows. Appropriate univariate and bivariate analysis were carried out using the Student's t test and two-tailed Fisher exact test or Chi-square test for categorical variables.

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“…No que diz respeito somente a mulheres positivas para o HIV, estudo africano utilizando a citologia encontrou prevalência de SIL de 12,3% 24 , enquanto o estudo chinês já citado, também utilizando a citologia oncótica, e incluindo ASCUS, encontrou 16% de SIL 20 . Estudos brasileiros utilizando a biópsia de colo uterino registraram prevalência de NIC de 23,4% em 494 mulheres HIV-positivas do Estado de Minas Gerais 25 , e de 18% em 255 mulheres HIV-positivas na cidade de São Paulo 26 . Os resultados do presente estudo foram de 15,4 e 2,4% de NIC, respectivamente, para as positivas e negativas para o HIV, o que está de acordo com os registros encontrados na literatura.…”

Section: Métodosunclassified

Prevalência de infecção cervical por papilomavírus humano e neoplasia intraepitelial cervical em mulheres HIV-positivas e negativas

Ceccato¹,

Lopes²,

Nascimento³

et al. 2015

Rev. Bras. Ginecol. Obstet.

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Resumo OBJETIVO: Realizar estudo comparativo entre mulheres positivas e negativas para o vírus da imunodeficiência humana (HIV), analisando: prevalência de neoplasia intraepitelial cervical (NIC) e infecção cervical pelo papilomavírus humano (HPV); risco viral e relação com desenvolvimento de NIC; parâmetros sociodemográficos e de comportamento que influenciaram na presença de infecção cervical por HPV e NIC. MÉTODOS: Estudo comparativo entre mulheres positivas e negativas para o HIV, sendo analisadas, respectivamente, 202 e 171 mulheres para avaliar a prevalência de NIC e 164 e 100 mulheres para avaliar a prevalência de infecção cervical pelo HPV. Em todas as consultas foram realizados: coleta de amostras cervicais para realização de citologia oncótica e reação em cadeia da polimerase (PCR) para detecção do DNA-HPV; colposcopia; questionário padronizado para coleta de dados demográficos/comportamentais; biópsia de todas as alterações colposcópicas. O exame histopatológico foi o padrão-ouro para o diagnóstico de NIC. RESULTADOS: A prevalência de NIC foi de 2,4 e 15,3% (p<0,001) e de infecção cervical pelo HPV foi de 37,1 e 55,5% (p=0,002), respectivamente, nas negativas e positivas para o HIV. As soropositivas tiveram mais infecção por HPV de alto risco (35,7 e 23,6%; p=0,02) e por múltiplos tipos (6,2 e 0%). O HPV 16 foi o tipo prevalente, ocorrendo em 11,3 e 10,2% das positivas e negativas para o HIV e também nas mulheres que tiveram NIC nos dois grupos. Os fatores associados ao desenvolvimento de NIC foram: infecção pelo HIV (HT=4,64; IC95% 2,23-9,65), idade (HT=0,95; IC95% 0,93-0,98 para cada ano de vida) e estado civil (HT=0,49; IC95% 0,30-0,80). Os fatores associados à infecção pelo HPV foram: presença do HIV (HT=2,72; IC95% 1,77-4,17), maior número de parceiros sexuais (HT=1,87; IC95% 1,23-2,84), idade (HT=0,97; IC95% 0,95-0,99 para cada ano de vida) e estado civil (HT=0,65: IC95% 0,42-1,0 para união estável/viúvas). CONCLUSÃO: A prevalência de NIC e infecção cervical pelo HPV foi maior nas mulheres positivas para o HIV, que também apresentaram mais infecções por HPV de alto risco e múltiplos tipos. O tipo 16 foi o predominante nos dois grupos e nas mulheres que tiveram NIC. As mulheres com mais idade e união estável/viúvas tiveram menor chance de adquirir infecção cervical por HPV e NIC. AbstractPURPOSE: To conduct a comparative study between two groups of women (HIV positive and negative) analyzing: the prevalence of cervical intraepithelial neoplasia (CIN) and cervical HPV infection; viral risk and relationship with development of CIN; and sociodemographic and behavioral parameters that influence cervical HPV infection and the development of CIN. METHODS: A cross-sectional study in which 202 HIV-positive women and 164 HIV-negative women were analyzed to assess the prevalence of CIN and 171 HIV-positive women and 160 HIV-negative women were analyzed to assess the prevalence of cervical HPV infection. The following procedures were performed on the occasion of each medical visit: collection of cervical sa...

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Presence of multiple human papillomavirus types in cervical samples from HIV-infected women

Cited by 93 publications

References 29 publications

Cross‐sectional analysis of oncogenic HPV viral load and cervical intraepithelial neoplasia

Cross‐sectional analysis of oncogenic HPV viral load and cervical intraepithelial neoplasia

Colposcopic Study of Lower Genital Tract Infections in HIV-Positive Women on Antiretroviral Therapy

Prevalência de infecção cervical por papilomavírus humano e neoplasia intraepitelial cervical em mulheres HIV-positivas e negativas

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