Presence of neuroendocrine cells during postnatal development in rat prostate: Immunohistochemical, molecular, and quantitative study

Nam

Journal of Biological Chemistry

et al. 2004

Section: Identification Of Rpnecs and Atp-inducedmentioning

confidence: 99%

“…5 and 6), most likely serotonin (4,24). The single amperometric spikes in RPNECs usually display 5-10 ms of halfamplitude width.…”

Section: Stimulation Of P2x (But Not P2y) Induces Exocytosis In Rpnecs-mentioning

confidence: 99%

Purinergic Receptors Coupled to Intracellular Ca2+ Signals and Exocytosis in Rat Prostate Neuroendocrine Cells

Nam

Journal of Biological Chemistry

et al. 2004

“…The increase of these cells was related to the onset of puberty and their decline with aging. These findings might suggest androgenic modulation for the development of this cell population (Rodriguez et al, 2003). The innervation of the prostate compartments close to the epithelium (periglandular and periductal) was more relevant for classifying the rats by age than interglandular (stromal) innervation; NPY and VIP were found particularly associated.…”

Section: Discussionmentioning

confidence: 80%

“…The function of the neuroendocrine cells described in the rat prostate could be related to the excretion of prostate secretions toward the urethra, and these cells might be regulated by androgens (Rodriguez et al, 2003). Recently, several studies have claimed that neuroendocrine cells from human prostate could be implicated in the pathogenesis of BPH (Martin et al, 2000) and in prostate cancer (Cohen et al, 1991;di Sant'Agnese, 1992;Abrahamsson, 1999).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evolution of Neuroendocrine Cell Population and Peptidergic Innervation, Assessed by Discriminant Analysis, During Postnatal Development of the Rat Prostate

Rodríguez¹,

Pozuelo²,

Alberca³

et al. 2011

Image Anal Stereol

Self Cite

Serotonin immunoreactive neuroendocrine cells and peptidergic nerves (NPY and VIP) could have a role in prostate growth and function. In the present study, rats grouped by stages of postnatal development (prepubertal, pubertal, young and aged adults) were employed in order to ascertain whether age causes changes in the number of serotoninergic neuroendocrine cells and the length of NPY and VIP fibres. Discriminant analysis was performed in order to ascertain the classificatory power of stereologic variables (absolute and relative measurements of cell number and fibre length) on age groups. The following conclusions were drawn: a) discriminant analysis confirms the androgen-dependence of both neuroendocrine cells and NPY-VIP innervation during the postnatal development of the rat prostate; b) periglandular innervation has more relevance than interglandular innervation in classifying the rats in age groups; and c) peptidergic nerves from ventral, ampullar and periductal regions were more age-dependent than nerves from the dorso-lateral region.

Effect of Prolactin and Bromocriptine on the Population of Prostate Neuroendocrine Cells from Intact and Cyproterone Acetate‐Treated Rats: Stereological and Immunohistochemical Study

Ingelmo¹,

Gómez²,

Martı́n³

et al. 2007

The Anatomical Record

Self Cite

This work deals with the quantification of serotonin-immunoreactive prostate neuroendocrine cells (NECs) in rats exposed to prolactin in normal, cyproterone acetate-exposed, and bromocriptine-exposed animals to establish the possible influence of prolactin with or without androgenic blockade on this cell population. Thirty male peripubertal Sprague-Dawley rats were grouped as controls (CT) and those treated with cyproterone acetate (CA), cyproterone acetate plus prolactin, cyproterone acetate plus bromocriptine, prolactin (PL), and bromocriptine (BC). The volume of ductal epithelium (Vep) and total number (NSER) of the NECs serotoninimmunoreactive were measured. NECs were detected in the periurethral ducts. Compared to CT, Vep was increased in PL and BC and NSER was decreased in CA and increased in the prolactin or bromocriptine groups. The androgenic blockade decreases NSER in rat prostate; PL induces in normal and cyproterone acetate-treated rats the increase of NSER; and BC exerts a local effect over the prostate similar to that described for PL.