Presence of nuclear grooves in endometrial cytology

Kaneko, Chiyuki; Funahashi, Masanori; Kato, Kazuo; Shamoto, Mikihiro; Kobayashi, Tadao K.

doi:10.1002/(sici)1097-0339(199807)19:1<63::aid-dc13>3.0.co;2-6

Cited by 5 publications

(2 citation statements)

References 7 publications

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“…atrophic smears, where they actually represent dead cells. Much more nonspecific were nuclear grooves, which have been detected in normal endometrial,22 vaginal,23 and intermediate cells in cervical smears,24, 25 where they have been reported in all phases of the menstrual cycle. However, in our experience, when associated with SILs, they are much coarser, with a central thick bar‐like chromatin condensation with or without clearing of the rest of the nucleus, and some associated nuclear change.…”

Section: Discussionmentioning

confidence: 99%

DNA methyltransferase 1 expression and promoter methylation of E‐cadherin in mucoepidermoid carcinoma

Shieh

Shiah

Jeng

et al. 2005

Cancer

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Cervical neoplasia is attributed to a persistent Human Papilloma Virus infection. The Pap smear being the mainstay of cervical cancer screening in low‐resource settings, we studied the nonclassical features which might indicate HPV infection. These included abortive koilocytes, mild dyskeratosis, parakeratosis, mild nuclear hyperchromasia, bi/multinucleation, measles cells, and keratohyaline‐like granules. Two hundred and eight women with a satisfactory Pap smear and a Hybrid Capture II test were compared against the “HPV Gold Standard” for validation of the nonclassical signs. This was defined as one with any/all of the following: definite HPV‐related lesions on Pap smear (LSIL and above), hrHPV positivity, and CIN I, or above on histology. The highest PPV and NPV were achieved by bi/multinucleation and mild nuclear hyperchromasia, respectively. The mean number of nonclassical signs for HPV Gold Standard‐positive and ‐negative groups was 5.52 and 3.12 per smear, respectively (P < 0.0005). Abortive koilocytes, mild dyskeratosis, mild nuclear hyperchromasia, bi/multinucleation, parakeratosis, and diffuse keratohyaline granules had the best correlation with the gold standard (P < 0.05). Addition of nonclassical signs to established intraepithelial lesions on Pap smear increased the sensitivity from 52.31to 59.10% and reduced the specificity from 100 to 98%. To maximize the benefit from grouping of these signs, various combinations were studied. The best was: abortive koilocytes, mild nuclear hyperchromasia, and bi/multinucleation. Another was abortive koilocytes, mild nuclear hyperchromasia, bi/multinucleation, and mild dyskeratosis. In conclusion, these signs proved useful for identifying HPV infection. Population‐based studies are required to corroborate our findings. Diagn. Cytopathol. 2010;38:645–651. © 2009 Wiley‐Liss, Inc.

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Section: Discussionmentioning

confidence: 99%

DNA methyltransferase 1 expression and promoter methylation of E‐cadherin in mucoepidermoid carcinoma

Shieh

Shiah

Jeng

et al. 2005

Cancer

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“…16 The presence of nuclear grooves has also been demonstrated in vaginal cytology and in endometrial smears from normal and hyperplastic endometrium. 17,18 In breast, nuclear grooves have been observed in benign and malignant lesions (36%-38% and 62%-78%, respectively). 19,20 In the latter, they are reported in several histological types (ductal, lobular, papillary, medullary, mucinous) regardless of grade ( Figures 1D and 1E).…”

Section: Pathogenesis and Diagnostic Significance Of Nuclear Grooves mentioning

confidence: 99%

Review Articles: Pathogenesis and Diagnostic Significance of Nuclear Grooves in Thyroid and Other Sites

Batistatou

Scopa

2008

Int J Surg Pathol

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Nuclear grooves are longitudinal invaginations of the nuclear envelope bilayer, which constitute a characteristic feature of papillary thyroid carcinoma. Their pathogenesis is not yet clear, but there is evidence for the involvement of a signaling pathway downstream of the protooncogene RET. The presence of nuclear grooves is not specific for papillary thyroid carcinoma because it has been documented in other types of thyroid neoplasms, in nonneoplastic thyroid lesions, in ovarian neoplasms (Brenner, adult granulosa cell, and transitional cell tumors), in breast carcinomas, in cervicovaginal and endometrial smears, in papillary neoplasms of several organs (such as papillary transitional cell carcinoma of the bladder, papillary renal cell carcinoma, papillary endometrioid carcinoma of the prostate), in thymic carcinomas, and in nonepithelial tumors.

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Enhancing the scope of conventional cervical cytology for detecting HPV infection

Nijhawan

Mittal

Suri

et al. 2010

Diagnostic Cytopathology

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Cervical neoplasia is attributed to a persistent Human Papilloma Virus infection. The Pap smear being the mainstay of cervical cancer screening in low-resource settings, we studied the nonclassical features which might indicate HPV infection. These included abortive koilocytes, mild dyskeratosis, parakeratosis, mild nuclear hyperchromasia, bi/multinucleation, measles cells, and keratohyaline-like granules. Two hundred and eight women with a satisfactory Pap smear and a Hybrid Capture II test were compared against the "HPV Gold Standard" for validation of the nonclassical signs. This was defined as one with any/all of the following: definite HPV-related lesions on Pap smear (LSIL and above), hrHPV positivity, and CIN I, or above on histology. The highest PPV and NPV were achieved by bi/multinucleation and mild nuclear hyperchromasia, respectively. The mean number of nonclassical signs for HPV Gold Standard-positive and -negative groups was 5.52 and 3.12 per smear, respectively (P < 0.0005). Abortive koilocytes, mild dyskeratosis, mild nuclear hyperchromasia, bi/multinucleation, parakeratosis, and diffuse keratohyaline granules had the best correlation with the gold standard (P < 0.05). Addition of nonclassical signs to established intraepithelial lesions on Pap smear increased the sensitivity from 52.31 to 59.10% and reduced the specificity from 100 to 98%. To maximize the benefit from grouping of these signs, various combinations were studied. The best was: abortive koilocytes, mild nuclear hyperchromasia, and bi/multinucleation. Another was abortive koilocytes, mild nuclear hyperchromasia, bi/multinucleation, and mild dyskeratosis. In conclusion, these signs proved useful for identifying HPV infection. Population-based studies are required to corroborate our findings.

show abstract

Presence of nuclear grooves in endometrial cytology

Cited by 5 publications

References 7 publications

DNA methyltransferase 1 expression and promoter methylation of E‐cadherin in mucoepidermoid carcinoma

DNA methyltransferase 1 expression and promoter methylation of E‐cadherin in mucoepidermoid carcinoma

Review Articles: Pathogenesis and Diagnostic Significance of Nuclear Grooves in Thyroid and Other Sites

Enhancing the scope of conventional cervical cytology for detecting HPV infection

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