Presence of polycystic ovary syndrome is associated with longer anogenital distance in adult Mediterranean women

Sánchez-Ferrer, María Luisa; Mendiola, Jaime; Hernández-Peñalver, Ana I.; Corbalán-Biyang, Shiana; Carmona-Barnosi, Ana; Prieto-Sánchez, María T; Nieto, Anı́bal; Torres-Cantero, Alberto M.

doi:10.1093/humrep/dex274

Cited by 58 publications

(50 citation statements)

References 55 publications

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“…As mid-gestation amniotic fluid T originates from the fetus [56,57], elevated T levels suggest hyperandrogenism in fetal daughters of women with PCOS during a crucial developmental window when female NHPs and humans are vulnerable to PCOS-like developmental programming [34,58]. Consistent with these findings and the well-established, androgen receptor-mediated, elongation of the anogenital distance (AGD) as an initial component of genital virilization, newborn daughters of women with PCOS [29], as well as adult PCOS women [59][60][61], exhibit elongated AGDs. Differential patterns of DNA methylation in newborn girls of PCOS women [52], as well as in adult PCOS women themselves [26,62,63], implicate epigenetic modifications during a critical developmental window, potentially indicative of changes in degree of individual gene expression.…”

Section: The Evidence For Developmental Origins Of Pcos From Clinicalmentioning

confidence: 59%

Naturally Occurring and Experimentally Induced Rhesus Macaque Models for Polycystic Ovary Syndrome: Translational Gateways to Clinical Application

et al. 2019

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Indian rhesus macaque nonhuman primate models for polycystic ovary syndrome (PCOS) implicate both female hyperandrogenism and developmental molecular origins as core components of PCOS etiopathogenesis. Establishing and exploiting macaque models for translational impact into the clinic, however, has required multi-year, integrated basic-clinical science collaborations. Paradigm shifting insight has accrued from such concerted investment, leading to novel mechanistic understanding of PCOS, including hyperandrogenic fetal and peripubertal origins, epigenetic programming, altered neural function, defective oocytes and embryos, adipogenic constraint enhancing progression to insulin resistance, pancreatic decompensation and type 2 diabetes, together with placental compromise, all contributing to transgenerational transmission of traits likely to manifest in adult PCOS phenotypes. Our recent demonstration of PCOS-related traits in naturally hyperandrogenic (High T) female macaques additionally creates opportunities to employ whole genome sequencing to enable exploration of gene variants within human PCOS candidate genes contributing to PCOS-related traits in macaque models. This review will therefore consider Indian macaque model contributions to various aspects of PCOS-related pathophysiology, as well as the benefits of using macaque models with compellingly close homologies to the human genome, phenotype, development and aging.

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Section: The Evidence For Developmental Origins Of Pcos From Clinicalmentioning

confidence: 59%

Naturally Occurring and Experimentally Induced Rhesus Macaque Models for Polycystic Ovary Syndrome: Translational Gateways to Clinical Application

et al. 2019

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“…Similarly, short and long AGD measurements have not been both associated with clinical outcomes in epidemiological studies. For example, AGD AC but not AGD AF has been recently associated with polycystic ovarian syndrome, 19 while AGD AF (but not with AGD AC ) was associated with ovarian follicle number, 16 and with the occurrence of endometriomas or deep infiltrating endometriosis 18 in two other studies. As seen in Figure 1, the measurements with both protocols are not totally equivalent, since they have different landmarks.…”

Section: Discussionmentioning

confidence: 92%

“…Recently, Barret et al have correlated shorter AGD in female fetuses to higher first‐trimester bisphenol A in their mothers . In adult women, AGD measurements have been associated with hormone‐dependent gynaecological pathologies, such as endometriosis or polycystic ovarian syndrome . Recently, differences in AGD measurements have been found between women with and without pelvic floor organ prolapse .…”

Section: Introductionmentioning

confidence: 99%

“…14 In adult women, [15][16][17] AGD measurements have been associated with hormone-dependent gynaecological pathologies, such as endometriosis 18 or polycystic ovarian syndrome. 19 Recently, differences in AGD measurements have been found between women with and without pelvic floor organ prolapse. 20 The use of AGD in male and female human studies is emerging in clinical practice 21,22 and standardization of the techniques for AGD appraisal are currently available.…”

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confidence: 99%

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Comparability between adult female anogenital distance and perineal measurements standardized by POP‐Q system (GH and PB)

Sánchez-Ferrer

Prieto-Sánchez

Moya-Jiménez

et al. 2018

Neurourology and Urodynamics

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“…This was a case-control study conducted from September 2014 to May 2016 at the Department of Obstetrics and Gynecology of the University Clinical Hospital "Virgen de la Arrixaca" in the Murcia Region (southeastern Spain). The study conception and design have been previously described elsewhere (Sánchez-Ferrer et al 2017). Women were excluded if they: were <18 and >40 years old, had endocrine disorders (e.g.…”

Section: Study Populationmentioning

confidence: 99%

Health-related quality of life in women with polycystic ovary syndrome attending to a tertiary hospital in Southeastern Spain: a case-control study.

Sánchez-Ferrer

Adoamnei

Prieto-Sánchez

et al. 2020

Preprint

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Background: Polycystic ovary syndrome (PCOS) is a chronic condition with symptoms affecting many women at reproductive age and evaluating their health-related quality of Life (HRQoL) is an important issue. Moreover, differences in the HRQoL between women with different PCOS phenotypes have never been analyzed. Therefore, the aim of our study was to compare the HRQoL between women with PCOS -and its phenotypes- and controls attending to a tertiary hospital. Methods: A group of 117 women with PCOS and 153 controls were studied between 2014 and 2016. Controls were women without PCOS attending the gynecological outpatient clinic for routine examinations. Cases were women attending the same setting and diagnosed with PCOS. PCOS diagnose was performed following the Rotterdam Criteria and women were further classified by anovulatory or ovulatory phenotypic subtype. Women underwent physical and gynecological exams and completed health questionnaires including the Short Form-12v2. Eight scales and two component summary scores [Physical (PCS) and Mental (MCS), respectively] were calculated. Bivariate and multivariate analyses were performed to assess differences in HRQoL between women with PCOS and controls. Results: All women with PCOS and anovulatory PCOS presented lower score in PCS compared to controls [mean (95%CI): 53.7 (52.5-54.9) and 52.9 (51.5-54.4) vs. 55.8 (54.8-56.8); p-values<0.01], as well as lower scores for five out of the eight scales (p-values < 0.05) after adjusting by age, body mass index, infertility, educational level and current occupation. No significant differences were observed for the MCS between women with or without PCOS or its phenotypic subtypes. Conclusions: HRQoL was significantly decreased in adult women with PCOS and its anovulatory phenotype compared to controls attending the outpatient clinic of a tertiary hospital. These results may have implications for the clinical practice and suggest the need for specific interventions in women with PCOS.

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Presence of polycystic ovary syndrome is associated with longer anogenital distance in adult Mediterranean women

Abstract: Not applicable.

Cited by 58 publications

References 55 publications

Naturally Occurring and Experimentally Induced Rhesus Macaque Models for Polycystic Ovary Syndrome: Translational Gateways to Clinical Application

Naturally Occurring and Experimentally Induced Rhesus Macaque Models for Polycystic Ovary Syndrome: Translational Gateways to Clinical Application

Comparability between adult female anogenital distance and perineal measurements standardized by POP‐Q system (GH and PB)

Health-related quality of life in women with polycystic ovary syndrome attending to a tertiary hospital in Southeastern Spain: a case-control study.

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