Presence of rare hepatitis C virus subtypes, 2j, 2k, and 2r in Mexico City as identified by sequencing

Uribe-Noguez, Luis Antonio; Ocaña-Mondragón, Alicia; Mata‐Marín, José Antonio; Gómez-Torres, María Elena; Ribas‐Aparicio, Rosa María; Martínez-Rodríguez, María de la Luz

doi:10.1002/jmv.25070

Cited by 4 publications

(1 citation statement)

References 27 publications

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“…For example, in Martinique, there is a diverse circulation of G2 [15], different from the one circulating in Venezuela. HCV G2j has been reported in other countries of America, such as Canada [16], Argentina [17], and Mexico [18]. However, the high prevalence of HCV G2j in Venezuela is a unique situation, as a possible consequence of the slave trade from West Africa around 1785 [9].…”

Section: Discussionmentioning

confidence: 99%

Variation in Hepatitis C Virus Subtype Distribution during 20 Years in Venezuela

2019

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Objective: Hepatitis C virus (HCV) infection is a public health problem and a major cause of chronic hepatitis. This virus exhibits a great genetic variability, with 8 genotypes and numerous subtypes. The aim of this study was to evaluate the fluctuations of HCV subtypes during 2 decades in Venezuela. Methods: HCV genotypes were determined by direct sequencing of the 5ʹ-noncoding region in 392 isolates circulating in patients attended during the years 2014-2015. HCV subtype assignment was confirmed in a subset of samples (n = 24) by partial sequencing of the NS5B region. The genotype distribution was compared with the one observed in a previous study of patients followed up during the years 1994-1996 and 2005-2006. Results: Some variation was observed in the HCV genotype distribution over these 20 years. HCV genotype 1b prevalence was reduced significantly from 1994-1995 to 2004-2005, as previously described, and then remained constant. During the last 10 years, a significant decrease of HCV subtype 2b (36/237 in 2005-2006 vs. 24/392 in 2014-2015, p < 0.001) was observed. Patients infected with HCV G2acj were significantly older than the ones infected with G1 (53 vs. 47 years, p = 0.004), and male sex was significantly more prevalent among G3a-infected patients compared to the other ones (71 vs. 47%, p = 0.047). Conclusions: Fluctuations in HCV subtype distribution have been observed over 2 decades in Venezuela. Different major mode of transmission and susceptibility to the available HCV treatment during each period might be playing a role in the observed fluctuations in HCV subtype distribution.

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