2021
DOI: 10.3390/medicina57060523
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Presence of SARS-CoV-2 and Its Entry Factors in Oral Tissues and Cells: A Systematic Review

Abstract: Background and Objectives: The aim of this systematic review is to summarize the current data about the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its entry factors in oral tissues and cells. Materials and Methods: This systematic review was carried out based on the Preferred Reporting Items for a Systematic Review and Meta-Analysis (PRISMA). Three databases were analyzed (Pubmed, Web of science and Scopus) by three independent researchers. From the 18 identified studies, 10 o… Show more

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Cited by 10 publications
(14 citation statements)
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“…These findings demonstrated that the salivary glands are a reservoir for SARS-CoV-2, supporting the use of the saliva as a diagnostic method for COVID-19 and the role of this biological fluid in spreading the disease (118). TMPRSS3, TMPRSS4, TMPRSS5, and TMPRSS7 correlate with the ACE-2 expression in salivary glands, and these receptors are overexpressed when the basal cells in the oral cavity are differentiated to suprabasal cells (120). However, this cellular differentiation prepares the cells to shed from the oral cavity (121).…”
Section: Transmembrane Serine Proteases (Tmprss)mentioning
confidence: 53%
See 1 more Smart Citation
“…These findings demonstrated that the salivary glands are a reservoir for SARS-CoV-2, supporting the use of the saliva as a diagnostic method for COVID-19 and the role of this biological fluid in spreading the disease (118). TMPRSS3, TMPRSS4, TMPRSS5, and TMPRSS7 correlate with the ACE-2 expression in salivary glands, and these receptors are overexpressed when the basal cells in the oral cavity are differentiated to suprabasal cells (120). However, this cellular differentiation prepares the cells to shed from the oral cavity (121).…”
Section: Transmembrane Serine Proteases (Tmprss)mentioning
confidence: 53%
“…However, this cellular differentiation prepares the cells to shed from the oral cavity (121). Furthermore, the stratified squamous cells of the oral cavity are not linked to specific symptoms and shed continuously in the saliva, which could result in asymptomatic COVID-19 patients (120,121).…”
Section: Transmembrane Serine Proteases (Tmprss)mentioning
confidence: 99%
“…The virus has a tropism for cells that have two specific receptors: angiotensin-converting enzyme 2 (ACE2) [ 12 ] and transmembrane serine protease-2 (TMPRSS2), which are mainly present in the lungs [ 13 ]. These receptors have been identified in epithelial cells of the tongue (spinous cell layer, stratum corneum, and epithelial surface), gingival tissues, oral mucosa, taste cells of human fungiform papillae, and salivary glands (ductal, acinar, and myoepithelial cells); thus, the oral cavity has gained relevance in the pathogenesis of the disease [ 13 , 14 , 15 ].…”
Section: Structure Of Sars-cov-2mentioning
confidence: 99%
“…The highest SARS-CoV-2 viral loads are found in the nasal cavity, nasopharynx, and oropharynx in relation to the high expression of the ACE2 receptor [ 15 ]. The mouth is part of the oropharynx, and harbors bacteria and viruses from the nose, throat, respiratory tract, and contaminated saliva, which can spread viral infections [ 16 ].…”
Section: Importance Of the Transmission And Pathogenicity Of Sars-cov...mentioning
confidence: 99%
“…Исследователи из Мексики в систематическом обзоре проанализировали наличие SARS-CoV-2 и его факторов проникновения (АПФ2, трансмембранные сериновые протеазы -TMPRSS и фурин), и полученные ими результаты показывают, что SARS-CoV-2 может инфицировать широкий спектр тканей и клеток полости рта [10].…”
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