Presence of T-275A and C-2152T Polymorphisms of the Promoter Region of Uridine Diphosphate-Glucuronosyltransferase 1A9 Increases Mortality From Digestive Tumors: Results After 10 Years of Follow-up in a Renal Transplant Population

Calvo, N.; Shabaka, Amir; Cubillo, B. Rodriguez; Manzanara, Virginia Lopez de la; Pérez‐Flores, Isabel; Higuera, Mónica; Bautista, Juan Antonio; Sánchez‐Fructuoso, Ana

doi:10.1016/j.transproceed.2016.09.018

Cited by 1 publication

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“…UGT family could contribute to cancer risk by modulating the kidney exposure to mutagenic stimuli [29]. Expression changes of UGT family genes can affect the development and progression of various types of cancer including the cancer of the kidney cancer [30][31][32][33]. Moreover, it was also noticed that Cell migration and immune response process were enriched in KIRC and KIRP by GO and KEGG analysis(Supplemental Figure1,2).…”

Section: Discussionmentioning

confidence: 95%

Molecular Signature Of Subtypes Of Renal Cell Carcinomas And Immunotherapy Strategy

Guo¹,

Yu²,

He³

et al. 2022

Preprint

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Purpose: Classified immunogenomic profiling based on therapeutic responses in RCC subtypes.Methods: Tumors from RCC patients from The Cancer Genome Atlas (TCGA) cohort were analyzed, and genomic profiling was performed. We classified RCC on the basis of the immunogenomic profiling of 29 immune signatures.Results: We investigated the transcriptional changes of three RCC subtypes by RNA-seq. Gene ontology (GO) identify specific gene signatures differed significantly between KIRC, KIRP and KICH related to the distinct pathways. Site of origin within the nephron was one major determinant in the molecular and immune classification, reflecting differences between three subtypes. The Immunity High KIRC and KIRP subtype was enriched not only in immune signatures, but also including PD-L1 expression signaling, NF-kappa B signaling pathway, JAK-STAT signaling pathway and Cell cycle signaling pathway. KICH was a distinct disease that shared little genomic characteristics with KIRC and KIRP.Conclusions: The identification of RCC subtypes based on immune signatures has potential clinical implications for RCC treatment. It is imaginable that patients with higher immunity subtype of KIRC and KIRP would be more likely to respond to anti-PD-1/ PD-L1 therapy than patients with KICH subtype. CCL21 and CCL25 might be a potential target for KICH therapy.

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