Presence of the posterior pituitary bright spot sign on MRI in the general population: a comparison between 1.5 and 3T MRI and between 2D-T1 spin-echo- and 3D-T1 gradient-echo sequences

Klyn, Verena; Dekeyzer, Sven; Eetvelde, Ruth Van; Roels, P; Vergauwen, Ortwin; Devolder, Pieter; Wiesmann, Martin; Achten, Eric; Nikoubashman, Omid

doi:10.1007/s11102-018-0885-3

Cited by 14 publications

(12 citation statements)

References 10 publications

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“…The sample size can be estimated according to the following formula: n=Z 2 × [P × (1-P)]/E 2 , where n is the sample size, Z is the statistical value and E is the error. When the confidence is 95%, Z=1.96; P represents the incidence of PPBS- in the normal population, which is 4.1% according to the latest literature (19). E was set to 10% in the current study.…”

Section: Methodsmentioning

confidence: 99%

MRI and pathological features of Rathke cleft cysts in the sellar region

Wang

Nie

et al. 2019

Exp Ther Med

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The aim of the present study was to investigate the MRI and pathological features of Rathke cleft cysts (RCC) in the sellar region. A total of 45 RCC cases were retrospectively analyzed. RCC size, location, intracyst nodules and general signals, as well as the posterior pituitary bright spot (PPBS) were analyzed using MRI-T1 weighted images (T1WI) and T2WI. The relationship between the presence of PPBS and histopathological features was additionally evaluated. On T1WI, there were 18 cases of isointense signal, 16 cases of hyperintense signal, 9 cases of hypointense signal, 1 case of heterogeneous signal and 1 case with a stratification effect, with isointense signal in the upper part and hyperintense signal in the lower part. On T2WI, there were 5 cases of isointense signal, 27 cases of hyperintense signal, 11 cases of hypointense signal and 1 case of the stratification effect. There were 10 cases of PPBS+ and 35 cases of PPBS-. There were no significant differences in the age, sex, cyst location and size between PPBS+ and PPBS- cases. However, PPBS+ cases had significantly lower inflammation than PPBS- cases. A total of 20 cases of intracystic nodules were identified on MRI scans, most of which exhibited T2 -hypointense signals. The shape of RCC nodules varied and there were 17 cases where the nodules were non-adherent to the cyst wall. The MRI signals of RCCs varied and most nodules were floating within cysts. Intracystic nodules are characteristic features of RCCs when observed by MRI and thus are of high diagnostic value. Most patients with RCC were also PPBS-, which may be associated with an increased inflammatory response.

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Section: Methodsmentioning

confidence: 99%

MRI and pathological features of Rathke cleft cysts in the sellar region

Wang

Nie

et al. 2019

Exp Ther Med

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“…Thus, we performed a complete radiological and serological study (Table 1). Lab tests did not show alterations in pituitary hormones, and pituitary magnetic resonance imaging (MRI) manifested a lack of a neurohypohyseal bright signal, which was attributed to a normal physiological occurrence in the absence of any clinical suspicion [28]. A computed tomography (CT) of the chest and abdomen indicated enlarged right adrenal gland and bilateral renal cysts without clinical significance.…”

Section: Clinical Evolution After the Genetic Resultsmentioning

confidence: 98%

Novel germline variants of CDKN1B and CDKN2C identified during screening for familial primary hyperparathyroidism

Mazarico-Altisent

Capel

Baena

et al. 2022

J Endocrinol Invest

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Purpose CDKN1B mutations were established as a cause of multiple endocrine neoplasia 4 (MEN4) syndrome in patients with MEN1 phenotype without a mutation in the MEN1 gene. In addition, variants in other cyclin-dependent kinase inhibitors (CDKIs) were found in some MEN1-like cases without the MEN1 mutation. We aimed to describe novel germline mutations of these genes in patients with primary hyperparathyroidism (PHPT). Methods During genetic screening for familial hyperparathyroidism, three novel CDKIs germline mutations in three unrelated cases between January 2019 and November 2021 were identified. In this report, we describe clinical features, DNA sequence analysis, and familial segregation studies based on these patients and their relatives. Genome-wide DNA study of loss of heterozygosity (LOH), copy number variation (CNV), and p27/kip immunohistochemistry was performed on tumour samples. Results DNA screening was performed for atypical parathyroid adenomas in cases 1 and 2 and for cystic parathyroid adenoma and young age at diagnosis of PHPT in case 3. Genetic analysis identified likely pathogenic variants of CDKN1B in cases 1 and 2 and a variant of the uncertain significance of CDKN2C, with uniparental disomy in the tumour sample, in case 3. Neoplasm screening of probands showed other non-endocrine tumours in case 1 (colon adenoma with dysplasia and atypical lipomas) and case 2 (aberrant T-cell population) and a non-functional pituitary adenoma in case 3. Conclusion Germline mutations in CDKIs should be included in gene panels for genetic testing of primary hyperparathyroidism. New germline variants here described can be added to the current knowledge.

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“…The normal posterior pituitary is located in the sella turcica and shows hyperintense signals on T 1 WI. These hyperintense signals are related to the storage of antidiuretic hormones in neuroendocrine granules (8). In some congenital or acquired lesions, this hyperintense signal can be ectopic to other extrasellar locations, called EPPHS.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of magnetic resonance imaging ectopic posterior pituitary hyperintense signal in pituitary macroadenoma

Luo

Fan

et al. 2022

Front. Oncol.

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ObjectiveWhen the lesions in the sellar region are large, they can involve both the inside and outside the sella, which brings challenges to the differential diagnosis of pituitary macroadenoma and lesions other than macroadenoma. Therefore, this study explored the diagnostic value of an ectopic posterior pituitary hyperintense signal (EPPHS) in pituitary macroadenoma and its possible causes.MethodsThe clinical and imaging data of 131 patients with sellar tumors or tumor-like lesions involving both intrasellar and extrasellar regions in the Affiliated Hospital of Guizhou Medical University from February 2011 to December 2021 were analyzed retrospectively. The diagnostic value of EPPHS in pituitary macroadenoma was analyzed. The differences in clinical and imaging indexes between the EPPHS-positive group and the EPPHS-negative group were compared.ResultsThese 131 cases of sellar tumors or tumor-like lesions involving both intrasellar and extrasellar regions included 91 cases of pituitary macroadenoma and 40 cases of lesions other than macroadenoma. The receiver operator characteristic (ROC) curve analysis suggested that EPPHS had a diagnostic value in diagnosing pituitary macroadenoma [area under the curve (AUC) = 0.857, P = 0.0001]. Compared with the EPPHS negative group, the median prolactin level in the EPPHS positive group was significantly higher (P < 0.05). Through ROC curve analysis, prolactin value was found to be of diagnostic value for EPPHS (AUC = 0.612, P = 0.0312).ConclusionIn sellar tumors or tumor-like lesions involving both intrasellar and extrasellar regions, the appearance of EPPHS is helpful in the diagnosis of pituitary macroadenoma. The formation of EPPHS may be related to injuries to the pituitary stalk.

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Presence of the posterior pituitary bright spot sign on MRI in the general population: a comparison between 1.5 and 3T MRI and between 2D-T1 spin-echo- and 3D-T1 gradient-echo sequences

Cited by 14 publications

References 10 publications

MRI and pathological features of Rathke cleft cysts in the sellar region

MRI and pathological features of Rathke cleft cysts in the sellar region

Novel germline variants of CDKN1B and CDKN2C identified during screening for familial primary hyperparathyroidism

Diagnostic value of magnetic resonance imaging ectopic posterior pituitary hyperintense signal in pituitary macroadenoma

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