2012
DOI: 10.7314/apjcp.2012.13.3.867
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Presence of Tumour-infiltrating FOXP3+Lymphocytes Correlates with Immature Tumour Angiogenesis in Renal Cell Carcinomas

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Cited by 17 publications
(11 citation statements)
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References 32 publications
(33 reference statements)
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“…Their recruitment seems to be induced by the CCL22/CCR4 and TGF-β/VEGF-A axes (Busse et al, 2011;Desar et al, 2011;Li et al, 2012). The expansion of T reg subpopulation within PBL and TIL in RCC-bearing patients has been associated with advanced TNM stages (Dannenmann et al, 2013;Li et al, 2015), denser tumor microvascularization (Zhan, Gao, Zhou, Pu, & Wang, 2012), and poor survival (Kang et al, 2013;Li et al, 2010;Li, Chu, et al, 2009;Liotta et al, 2011).…”
Section: The Ccrcc Tumor Microenvironmentmentioning
confidence: 98%
“…Their recruitment seems to be induced by the CCL22/CCR4 and TGF-β/VEGF-A axes (Busse et al, 2011;Desar et al, 2011;Li et al, 2012). The expansion of T reg subpopulation within PBL and TIL in RCC-bearing patients has been associated with advanced TNM stages (Dannenmann et al, 2013;Li et al, 2015), denser tumor microvascularization (Zhan, Gao, Zhou, Pu, & Wang, 2012), and poor survival (Kang et al, 2013;Li et al, 2010;Li, Chu, et al, 2009;Liotta et al, 2011).…”
Section: The Ccrcc Tumor Microenvironmentmentioning
confidence: 98%
“…[33] demonstrated that an increased prevalence of circulating CD4+CD25highFoxp3+ Tregs was associated with high mortality and reduced survival time in hepatocellular carcinoma patients. In contrast, not all investigators have confirmed the relationship between the level of Foxp3/CTLA-4 and clinicomorphological features [17, 21, 32]. For instance, Peng et al .…”
Section: Discussionmentioning
confidence: 99%
“…Zhan et al . [21] indicated that the presence of Foxp3 positive cells in renal carcinomas did not significantly correlate with survival and other pathological characteristics. However, the researchers demonstrated that TIL Foxp3 lymphocytes correlated with immature tumor angiogenesis.…”
Section: Discussionmentioning
confidence: 99%
“…Tregs have been confirmed to participate not only in autoimmunity, graft rejection but also in tumors. An increased percentage of Tregs in CD4+ T cells has been found in peripheral blood and tumour infiltrating lymphocytes of cancer patients, and high level of Tregs is an indicator of poor prognosis (Shen et al, 2010;Zhan et al, 2012;Wang et al, 2013). Tregs suppress antitumor immunity and are major obstacles for cancer immunotherapy.…”
Section: Introductionmentioning
confidence: 99%