“…Their recruitment seems to be induced by the CCL22/CCR4 and TGF-β/VEGF-A axes (Busse et al, 2011;Desar et al, 2011;Li et al, 2012). The expansion of T reg subpopulation within PBL and TIL in RCC-bearing patients has been associated with advanced TNM stages (Dannenmann et al, 2013;Li et al, 2015), denser tumor microvascularization (Zhan, Gao, Zhou, Pu, & Wang, 2012), and poor survival (Kang et al, 2013;Li et al, 2010;Li, Chu, et al, 2009;Liotta et al, 2011).…”