“…The Aβ42/40 ratios and ER Ca 2+ levels were normalized to the corresponding values for the WT (open triangle). The 3 PS1-FAD mutants with confirmed DCP pathology (M139V, M146L, A246E) [31, 44, 45] were plotted as solid circles, the 8 PS1-FAD mutants with confirmed CWP pathology (L166P, P436Q, P264L, ΔE8, E280G, ΔE9, T291P, C410Y) [13–15] were plotted as open circles, and the 2 PS1-FAD mutants with unknown pathology (G384A, L85P) were plotted as diamonds. For remaining 9 PS1-FAD mutants (G217D, K239E, V261F, E273A, L420R, A426P, A431E, R269G, N405S) Aβ42/40 values were not available and these mutants could not yet be plotted.…”