2023
DOI: 10.3390/biom13091401
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Presenilin-1-Derived Circular RNAs: Neglected Epigenetic Regulators with Various Functions in Alzheimer’s Disease

Nima Sanadgol,
Javad Amini,
Cordian Beyer
et al.

Abstract: The presenilin-1 (PSEN1) gene is crucial in developing Alzheimer’s disease (AD), a progressive neurodegenerative disorder and the most common cause of dementia. Circular RNAs (circRNAs) are non-coding RNA generated through back-splicing, resulting in a covalently closed circular molecule. This study aimed to investigate PSEN1-gene-derived circular RNAs (circPSEN1s) and their potential functions in AD. Our in silico analysis indicated that circPSEN1s (hsa_circ_0008521 and chr14:73614502-73614802) act as sponge … Show more

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Cited by 5 publications
(1 citation statement)
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“…PSEN1 mutations may exacerbate neuroin ammation by promoting Aβ accumulation and plaque formation, further contributing to neurodegeneration in Alzheimer's disease. Additionally, Aβ oligomers impair synaptic function, induce neuronal stress, disrupt calcium homeostasis, and trigger apoptotic pathways, leading to neuronal cell death and neurodegeneration [48,49].…”
Section: Psen1 (Presenilin 1)mentioning
confidence: 99%
“…PSEN1 mutations may exacerbate neuroin ammation by promoting Aβ accumulation and plaque formation, further contributing to neurodegeneration in Alzheimer's disease. Additionally, Aβ oligomers impair synaptic function, induce neuronal stress, disrupt calcium homeostasis, and trigger apoptotic pathways, leading to neuronal cell death and neurodegeneration [48,49].…”
Section: Psen1 (Presenilin 1)mentioning
confidence: 99%