2004
DOI: 10.1007/s10329-004-0076-x
|View full text |Cite
|
Sign up to set email alerts
|

Presenilin-2 in the cynomolgus monkey brain: investigation of age-related changes

Abstract: Localization of presenilin-2 (PS-2), a transmembrane protein implicated in early onset familial Alzheimer's disease, was examined in the brains of 30 cynomolgus monkeys aged 4 to 36 years. Anti-PS-2 antibody N20, which recognizes PS-2 amino acid residues 2-20, and anti-PS-2 antibody C20, which recognizes PS-2 amino acid residues 535-554, stained mainly the cytoplasm of large pyramidal neurons and large neurites. This finding was also confirmed by double immunohistochemical investigations using N20 or C20 and a… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2009
2009
2023
2023

Publication Types

Select...
2

Relationship

0
2

Authors

Journals

citations
Cited by 2 publications
(1 citation statement)
references
References 53 publications
0
1
0
Order By: Relevance
“…65 On the contrary, PSEN2 was also detected in large pyramidal neurons and neuritic plaques, but its expression level remained unchanged during aging of cynomolgus monkeys. 66 Recently, PSEN2 mRNA in the Chinese tree shrew has been characterised, demonstrating 97.64% sequence similarity to human PSEN2. 67 Even though the protein structure of PSEN2 indicates similarities to human PSEN2, tree shrew PSEN2 possesses only seven α-helices, while human PSEN2 contains ten α-helices.…”
Section: Aβ-associated Genetics and Proteins In Aged Nhpsmentioning
confidence: 99%
“…65 On the contrary, PSEN2 was also detected in large pyramidal neurons and neuritic plaques, but its expression level remained unchanged during aging of cynomolgus monkeys. 66 Recently, PSEN2 mRNA in the Chinese tree shrew has been characterised, demonstrating 97.64% sequence similarity to human PSEN2. 67 Even though the protein structure of PSEN2 indicates similarities to human PSEN2, tree shrew PSEN2 possesses only seven α-helices, while human PSEN2 contains ten α-helices.…”
Section: Aβ-associated Genetics and Proteins In Aged Nhpsmentioning
confidence: 99%