Present scenario of hemoglobinopathies in West Bengal, India: An analysis of a large population

Spectrum of hemoglobinopathies by high performance liquid chromatography with special reference to role of HbA2 levels at tertiary care centre

“…From many previously described studies, BetaThalassemia trait is most common hemoglobinopathy in India. [10][11][12] In present study, Sickle cell trait being most common Hemoglobinopathy detected as present study was hospital based, not community based and during period of study, large numbers of solubility positive samples from peripheral health centers were received. In the present study Occurrence of Hemoglobinopathies was highest in Buddhas (58.22%), followed by Muslim (16.57%) and Banjaras (10.16%).…”

Haemoglobin Variants among the Bengali Muslims and the Meiteis in two Villages of Cachar District of Assam, India

“…Agarwal [31] indicated that β-thalassemia is detectable in almost every Indian population, however, it is seen with the highest frequency in north-west and far-east. Two large scale studies on haemoglobinopathy reported by Madan et al [32] and Mandal et al [30] on the prevalence of β-thalassemia trait was 5.5% in northern India, 2.7% in western India and 6.6% in eastern India. Earlier study conducted by Indian Council of Medical Research (ICMR) from different cities of eastern India (Kolkata, West Bengal), north east India (Dibrugarh, Assam) and southern India (Bangalore, Karnataka) showed prevalence of β-thalassemia carriers was 3.64%, 1.48% and 2.16%, respectively [30].…”

“…Two large scale studies on haemoglobinopathy reported by Madan et al [32] and Mandal et al [30] on the prevalence of β-thalassemia trait was 5.5% in northern India, 2.7% in western India and 6.6% in eastern India. Earlier study conducted by Indian Council of Medical Research (ICMR) from different cities of eastern India (Kolkata, West Bengal), north east India (Dibrugarh, Assam) and southern India (Bangalore, Karnataka) showed prevalence of β-thalassemia carriers was 3.64%, 1.48% and 2.16%, respectively [30]. Uddin et al [33] reported on haemoglobinopathy from a hospital based study among the 210 peoples and revealed that the prevalence of thalassemia trait was 47.14%, HbE_β-thalassemia was 30.47%, HbE trait was 13.3%, HbE disease was 5.71% and thalassemia major were 3.33%.…”

“…Indian Council of Medical Research (ICMR) conducted a study covering mostly city based populations amongst six cities which includes Kolkata in West Bengal in the east, Dibrugarh in Assam in the north-east reported that the prevalence of HbE trait as 3.92% in Kolkata and 23.90% in Dibrugarh [29]. Mandal et al [30] studied on large samples from different rural areas of West Bengal and found the prevalence of HbE trait (2.78%). Agarwal [31] indicated that β-thalassemia is detectable in almost every Indian population, however, it is seen with the highest frequency in north-west and far-east.…”

“…Mandal et al [30] indicated that the occurrence of larger frequency of HbE in populations of Northeast India, Laos, Thailand and Cambodia forms 'haemoglobin E quadrangle'.…”