2010
DOI: 10.1002/biof.75
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Present trends in vitamin E research

Abstract: Abstract.Nearly after one century of research and thousands of publications, the physiological function(s) of vitamin E remain unclear. Available evidence suggests a role in cell homeostasis that occurs through the modulation of specific signaling pathways and genes involved in proliferative, metabolic, inflammatory, and antioxidant pathways. Vitamin E presence in the human body is under close metabolic control so that only a-tocopherol and, to a lower extent, c-tocopherol are retained and delivered to tissues… Show more

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Cited by 111 publications
(84 citation statements)
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“…As described in the previous section, the activity of d-T3 observed in this in vitro experimental model system, can be partially explained by a high uptake rate that rapidly brings the cell content of this vitamer to the levels required to produce its anti-cancer activity. However, experimental evidence clearly suggests the existence of a marked cell and disease-related specificity for T3 effects that suggests other and more complex mechanisms than a simple increase in the uptake rate, and this appear to be true also for the other forms of vitamin E [reviewed in (Galli and Azzi 2010)]. Intrinsic characteristics of cancer cells may sustain the therapeutic potential and specificity of action of T3.…”
Section: Metabolite Formation and Activitymentioning
confidence: 99%
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“…As described in the previous section, the activity of d-T3 observed in this in vitro experimental model system, can be partially explained by a high uptake rate that rapidly brings the cell content of this vitamer to the levels required to produce its anti-cancer activity. However, experimental evidence clearly suggests the existence of a marked cell and disease-related specificity for T3 effects that suggests other and more complex mechanisms than a simple increase in the uptake rate, and this appear to be true also for the other forms of vitamin E [reviewed in (Galli and Azzi 2010)]. Intrinsic characteristics of cancer cells may sustain the therapeutic potential and specificity of action of T3.…”
Section: Metabolite Formation and Activitymentioning
confidence: 99%
“…Upstream elements in this signaling include PKC and the survival pathway ERK-MAPK that is known to influence the mitochondrial signaling in response to foreign stimuli and endobiotics such as hormones and redox-active metabolites [recently reviewed in (Luchetti et al 2010)]. PKC was the former component in the cell signaling that was identified to be controlled by vitamin E (Galli and Azzi 2010) and is the earliest kinase that responds in a concentration and time-dependent manner to vitamin E leading to signal transduction from the plasmalemma to downstream elements. Membrane translocation and activity of PKC are directly influenced by chromanols (Varga et al 2008), which may provide a mechanism to explain the close correlation between kinetics profiles of anti-proliferative signaling and uptake rate (i.e., relative concentration within the lipid bilayer) of vitamin E molecules (Betti et al 2006).…”
Section: Metabolite Formation and Activitymentioning
confidence: 99%
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