Presentation and Management of Inguinal Lymphadenopathy in Ovarian Cancer

Giri, Shveta; Shah, Swati; Batra, Kanika; Anu-Bajracharya,; Jain, Vandana; Shukla, Himanshu; Sekhon, Rupinder; Rawal, Sudhir

doi:10.1007/s13193-016-0556-7

Cited by 11 publications

(11 citation statements)

References 13 publications

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“…Ovarian cancer presenting with isolated secluded inguinal lymph node metastases is also rarely reported (0.8–3%) presenting good prognosis after complete cytoreduction followed by chemotherapy [33,34,35,36,37]. Due to the lymphatic drainage mentioned, lymphatic dissemination is a common route of spread in ovarian tumors with lymphatic drainage occurring mainly via the infundibulopelvic ligament to the paraaortic lymph nodes, and thus, these nodes are easily involved with metastases through ovarian vessels.…”

Section: Pathways and Metastatic Sites Of Ovarian And Peritoneal Cmentioning

confidence: 99%

Rare Distant Metastatic Disease of Ovarian and Peritoneal Carcinomatosis: A Review of the Literature

Thomakos

Diakosavvas

Machairiotis

et al. 2019

Cancers

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Background: Although metastases of ovarian and peritoneal carcinomatosis are most commonly found within the peritoneal cavity, there is a number of other rare distant sites that have been reported. Our goal is to provide an evidence-based summary of the available literature considering the rare distant metastatic sites of ovarian and peritoneal carcinomatosis. Methods: A comprehensive search of the literature was conducted, with Medline/PubMed being searched for cases of rare metastatic disease originated from primary ovarian and peritoneal cancer with related articles up to 2019 including terms such as “ovarian cancer”, “metastases”, “peritoneal” and others. Results: The most common mechanism of ovarian cancer metastases consists of primarily dissemination within the peritoneal cavity, while, rare and distant sites can either occur at the beginning or during the course of the disease and they are usually associated with hematogenous route and lymphatic invasion, having poor prognosis, with the least common sites being skin, bone, CNS, eye, placenta, central airways, rare lymph nodes, intra-abdominal organs, heart and breast. Conclusions: The occurrence of metastatic sites described in this review represents the most common rare distant metastatic sites, and even though their patterns of metastases are still not fully clarified due to the rarity of the reports, they offer valuable information considering the pathophysiology of the disease.

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Section: Pathways and Metastatic Sites Of Ovarian And Peritoneal Cmentioning

confidence: 99%

Rare Distant Metastatic Disease of Ovarian and Peritoneal Carcinomatosis: A Review of the Literature

Thomakos

Diakosavvas

Machairiotis

et al. 2019

Cancers

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“…Due to the extent of the disease, only two patients were submitted to per-primam cytoreductive surgery while in all other cases neoadjuvant chemotherapy was needed in order to increase the resectability rate. However, the histopathological studies of the two patients submitted to surgery as the first intention therapeutic procedure demonstrated the presence of disseminated metastatic lesions at the level of the peritoneal biopsies as well as at the level of the pelvic, inguinal and para-aortic removed lymph nodes, demonstrating in this way that the contamination of the inguinal lymph nodes usually occur as part of the systemic development of this malignancy (15).…”

Section: Discussionmentioning

confidence: 85%

Normal Size Ovary Carcinoma Syndrome with Inguinal Ovarian Cancer Lymph Node Metastases – A Case Report and Literature Review

Bacalbaşa

Bălescu

Bălălău

et al. 2018

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Ovarian cancer remains an aggressive gynaecological malignancy associated with poor survival rates especially if complete cytoreductive surgery cannot be achieved. Most commonly it metastasises via peritoneal, haematogenous or lymphatic route, leading to the apparition of disseminated lesion from the moment of the initial diagnosis. However, even in cases presenting systemic disease, it seems that performing a maximal cytoreductive surgical procedure remains the only therapeutic chance to improve the overall survival (1-8). Most commonly patients diagnosed with ovarian cancer complain of weight loss, abdominal discomfort or distension, constipation or early satiety. In a very small number of cases all these signs might be missing, the only complain of the patient being related to the apparition of a unilateral or bilateral inguinal mass. This represents less than 3% of cases and consists of cases in which the lymphatic spread is directed mainly to the groin lymph node stations (9). Case ReportA 46-year-old patient with no significant medical history presented for the apparition of bilateral inguinal tumoral masses; the patient denied other signs or symptoms such as weight loss, fever, abdominal pain or constipation. A biopsy of the inguinal masses was performed, the histopathological studies revealing the presence of tumoral cells mimicking an adenocarcinoma probably originating from the gynaecological tract. The patient was submitted to vaginal ultrasound, cervical and endometrial biopsies; however no pathological results were found. She was also submitted to a full body computed tomography which revealed the presence of a few pelvic adenopathies, without any other modifications, so she was also submitted to a PET CT which revealed the presence of a high fixation area at the level of the both adnexal areas as well as in the inguinal areas; however, it should be mentioned that although both adnexas presented an increased fixation at PET CT none of the two ovaries were modified in volume at the standard computed tomography (Figure 1). The laboratory analyses revealed an 385

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“…Isolated inguinal lymph node metastasis is an uncommon manifestation of ovarian carcinoma. Only a few cases in which inguinal lymphadenopathy was the clinical manifestation of an epithelial ovarian tumor were described in the medical literature (7,(10)(11)(12)(13)(14)(15).…”

Section: Discussionmentioning

confidence: 99%

“…Isolated secluded inguinal lymph node metastasis is an uncommon manifestation of ovarian cancer. In most patients, a primary tumor was identified by either accurate imaging or a diagnostic surgical procedure (6,7).…”

Section: Introductionmentioning

confidence: 99%

High-grade serous carcinoma of unknown primary origin associated with STIC clinically presented as isolated inguinal lymphadenopathy: a case report

Giancontieri,

Turetta,

Barchiesi

et al. 2024

Front. Oncol.

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Serous tubal intraepithelial carcinoma (STIC) is a precancerous lesion of high-grade serous ovarian carcinoma (HGSOC). Usually, it arises from the fimbrial end of the tube, and it is associated with metastatic potential. On average, the time to progress from STIC to HGSOC is 6.5 years. Therefore, whenever a STIC lesion is found, surgical staging and prophylactic salpingectomy are recommended in order to prevent ovarian cancer. We report a rare case of a 45-year-old female patient who clinically presented an isolated right inguinal lymphadenopathy. The remaining clinical examination was normal. Therefore, an excisional biopsy of the lymph node was performed. Pathological analysis revealed a high-grade serous carcinoma, most likely of gynecological origin. Due to histological evidence, a computed tomography (CT) scan was carried out. There was no CT evidence of ovarian disease, pelvic involvement, intra-abdominal lymphadenopathies, metastatic disease, or ascites. All tumor markers were negative. The patient underwent laparoscopic hysterectomy and bilateral salpingo-oophorectomy followed by surgical staging. Surprisingly, pathological examination showed a STIC lesion in the fimbria of the left fallopian tube. We aim to report the potential capability of STIC to spread particularly through lymphatic pathways rather than peritoneal dissemination.

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Presentation and Management of Inguinal Lymphadenopathy in Ovarian Cancer

Cited by 11 publications

References 13 publications

Rare Distant Metastatic Disease of Ovarian and Peritoneal Carcinomatosis: A Review of the Literature

Rare Distant Metastatic Disease of Ovarian and Peritoneal Carcinomatosis: A Review of the Literature

Normal Size Ovary Carcinoma Syndrome with Inguinal Ovarian Cancer Lymph Node Metastases – A Case Report and Literature Review

High-grade serous carcinoma of unknown primary origin associated with STIC clinically presented as isolated inguinal lymphadenopathy: a case report

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