Presentation and severity of rheumatoid arthritis at diagnosis in Senegal

Ndongo, S.; Lekpa, Fernando Kemta; Ka, Mamadou Mourtalla; Ndiaye, Nafi; Diop, T. M.

doi:10.1093/rheumatology/kep178

Cited by 24 publications

(31 citation statements)

References 15 publications

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“…The rheumatoid factor, present in 78% of the British patients has only been found in 48% of Nigerians [20]. In the recent publications in this African region, we note a rise of the impact and the seriousness of the illness, even though a lower frequency [25]. These data agree with those of the western literature [1].…”

Section: Discussionsupporting

confidence: 90%

“…The strong seropositivity to the rheumatoid factor (54.5%) and to the anti-CCP antibodies (89.2%) noted in this study was also reported by Ndongo (rheumatoid factor: 78% and anti-CCP: 90%) [25] and by Ouédraogo (rheumatoid factor: 70% and anti-CCP: 80%) [24]. In the western literature we note the prevalence of the factor and superimpose able antibodies anti-CCP to these data [29] [30] [31].…”

Section: Discussionsupporting

confidence: 86%

“…Even though a lower frequency systemic manifestation is often reported in the west-African sequences [14] [24] [25] [26] five patients in 10 in our study presented articular extra manifestations. They were dominated by anemia (50.8%), followed by the dry oculo-buccal syndrome as a part of a secondary Sjögren syndrome (38.2%).…”

Section: Discussioncontrasting

confidence: 52%

“…Besides the active illness, the severity of the RA in our patients was marked by an important structural damage constituted of characteristic articular deformations in 53.3% of cases with erosions and or articular pinches in all patients. In 71.10% Open Journal of Internal Medicine the sequence of Ndongo the X-ray explorations showed some structural damages in 56% of the patients [25]. In a study assessing the structural damage in the RA in Benin Zomalhèto, et al listed some characteristic articular deformations in 7 cases in 10 and over half of patients had a score of Larsen superior to 40 [23].…”

Section: Discussionmentioning

confidence: 99%

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Severity of the Rheumatoid Arthritis in Sub-Saharan Africa: Study of 403 Senegalese Observations

Niasse¹,

Kane²,

Ndiaye³

et al. 2017

OJIM

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Introduction: We assess the severity of the rheumatoid arthritis in a Senegalese African black population. Patients and methods: It is a retrospective study achieved in the service of Internal Medicine of Aristide Le Dantec teaching hospital of Dakar between January 2005 and December 2016 in patients suffering from rheumatoid arthritis. We specified for every patient the predictive data of severity of the rheumatoid arthritis. Results: Four hundred and three patients have been gathered (39 men and 364 women), with the mean age of 45.8 years. An active tobacco addiction was noticed in 10 patients. The diagnostic delay was on average of 72 months. Characteristic articular deformations were noticed in 215 patients (53.3%). They were correlated to male (p = 0.038), to age (p = 0.001) and to the activity of the rheumatoid arthritis (p = 0.0445). Systemic manifestations have been observed in 213 cases (52.9%), particularly anemia (50.8%). They were correlated to the anti-CCP antibodies (p = 0.047). The ESR was increased at the first hour in 84.4% of cases (median: 43 mm; extreme: 1and 160). CRP was elevated in 63.71% of cases (median of 12 mg/l; extreme: 1 and 384). The rheumatoid factor was positive in 57.6% of the cases. The anti-CCP antibodies were present in 89.2% of the cases. Articular erosions were objectified in all cases. A DAS 28 superior to 5

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 86%

Section: Discussioncontrasting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

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Severity of the Rheumatoid Arthritis in Sub-Saharan Africa: Study of 403 Senegalese Observations

Niasse¹,

Kane²,

Ndiaye³

et al. 2017

OJIM

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“…Adewolo et al [18] observed that in 200 patients followed for RA in Nigeria only 38.5% were RF positive and 29% had joint erosions on radiographs of hands, while the average duration of symptoms was 63 months before the first consultation. Ndongo S et al [19] in Senegal reported that joint erosions were present in one-third of patients and that extra-articular manifestations were very rare, while the average time from the onset of symptoms to initiation of disease modifying antirheumatic drugs was 54 months. Anaya JM et al [20] in Colombia have described that RA was less severe in blacks than Mestizos in terms of radiographic damage.…”

Section: Discussionmentioning

confidence: 99%

The phenotype and genotype of rheumatoid arthritis in the Democratic Republic of Congo

et al. 2013

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IntroductionLittle is known about rheumatoid arthritis in the black, particularly in Congolese, populations. Our objective was to describe the phenotype and genotype of rheumatoid arthritis (RA) in Congolese.MethodsAll consecutive rheumatoid arthritis (RA) patients attending Kinshasa University Hospital in a three-year time period were included. Demographics, clinical features and tobacco consumption were noted. Disease Activity Score (DAS)-28 based on the erythrocyte sedimentation rate (ESR), Health Assessment Questionnaire (HAQ), anti-citrullinated peptide antibodies (CCP) antibodies and rheumatoid factor (RF) were determined. Radiographs were scored according to Sharp-van der Heijde. On a subset of patients and controls HLA-DRB1 typing was performed.ResultsA total of 114 females and 14 males aged 51.2 ± 14.9 were included. Mean duration of symptoms was four years. Moderate tobacco consumption was reported in a minority of patients. DAS-28 at first visit was >5.1 and HAQ ≥0.5 in all patients. X-rays showed joint erosions and/or joint space narrowing, mostly of a moderate grade in 55.8% of patients. Anti-CCP and/or RF were present in 48.6% of patients with available data (n = 72) and in 3.0% of controls (n = 67). Radiographic changes and nodules were more frequent in RF or anti-CCP positive patients. One copy of the shared epitope was found in 13 patients (35.1%) and 3 controls (12.5%). Two copies were found in one patient (2.7%) and in one control (4.2%).ConclusionCongolese patients with RA consult long after disease onset. Despite this delay, the majority presents without major damage and is RF, anti-CCP and SE negative. We put forward the hypothesis that besides different environmental factors there is probably also a particular genetic risk profile in Congolese patients, different from the HLA-DRB1 shared epitope.

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Nurse-led care for the management of rheumatoid arthritis: a review of the global literature and proposed strategies for implementation in Africa and the Middle East

et al. 2020

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Globally, increasing demand for rheumatology services has led to a greater reliance on non-physician healthcare professionals (HCPs), such as rheumatology nurse specialists, to deliver care as part of a multidisciplinary team. Across Africa and the Middle East (AfME), there remains a shortage of rheumatology HCPs, including rheumatology nurses, which presents a major challenge to the delivery of rheumatology services, and subsequently the treatment and management of conditions such as rheumatoid arthritis (RA). To further explore the importance of nurse-led care (NLC) for patients with RA and create a set of proposed strategies for the implementation of NLC in the AfME region, we used a modified Delphi technique. A review of the global literature was conducted using the PubMed search engine, with the most relevant publications selected. The findings were summarized and presented to the author group, which was composed of representatives from different countries and HCP disciplines. The authors also drew on their knowledge of the wider literature to provide context. Overall, results suggest that NLC is associated with improved patient perceptions of RA care, and equivalent or superior clinical and cost outcomes versus physician-led care in RA disease management. Expert commentary provided by the authors gives insights into the challenges of implementing nurse-led RA care. We further report practical proposed strategies for the development and implementation of NLC for patients with RA, specifically in the AfME region. These proposed strategies aim to act as a foundation for the introduction and development of NLC programs across the AfME region.

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Presentation and severity of rheumatoid arthritis at diagnosis in Senegal

Abstract: The diagnosis of RA is delayed in Senegal, and the disease is highly active at diagnosis, although 44 patients have no erosions, and extra-articular manifestations are rare.

Cited by 24 publications

References 15 publications

Severity of the Rheumatoid Arthritis in Sub-Saharan Africa: Study of 403 Senegalese Observations

Severity of the Rheumatoid Arthritis in Sub-Saharan Africa: Study of 403 Senegalese Observations

The phenotype and genotype of rheumatoid arthritis in the Democratic Republic of Congo

Nurse-led care for the management of rheumatoid arthritis: a review of the global literature and proposed strategies for implementation in Africa and the Middle East

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