Presentation and Survival of Operable Esophageal Cancer in Patients 55 Years of Age and Below

Hamouda, A.; Forshaw, Matthew; Rohatgi, Ashish; Mirnezami, Reza; Botha, A; Mason, Robert C.

doi:10.1007/s00268-010-0407-6

Cited by 25 publications

(22 citation statements)

References 27 publications

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“…However, age was not significantly associated with outcome among the cases with oesophageal cancer in our study (Fig 1b). Similar finding was observed in a study conducted by Hamouda A et al (5) which reviewed the presentation and survival of young patients with esophageal cancer. 365 esophagectomies were performed for cancer, of which 76 patients were younger than 55 years (20.8%) and 289 were older than 55 years.…”

Section: Agesupporting

confidence: 75%

Prognostic Factors for Oesophageal Cancer

Rege¹

2017

JMSCR

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Section: Agesupporting

confidence: 75%

Prognostic Factors for Oesophageal Cancer

Rege¹

2017

JMSCR

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“…For example, in a study by Portale et al (2004), approximately 12% of patients diagnosed with operable EC were aged 50 years or younger with advanced disease at presentation. Additionally, in a retrospective study, a significant proportion (20.8%) of patients presenting with operable EC was younger than 55 years old, and almost two-thirds of those presenting younger than 55 years had T3 stage tumors, which was significantly different than those older than 55 years (Hamouda et al, 2010). Likewise in the present results, the risk of developing EC was significantly decreased with aging in case-patients, which reinforces the surging incidence and prognostic outcome of EC in younger patients.…”

Section: Discussionmentioning

confidence: 98%

Meta-Analysis of the NAD(P)H: Quinine Oxidoreductase 1 Gene 609 C>T Polymorphism with Esophageal Cancer Risk

Wang

Zhong

2012

DNA and Cell Biology

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Association between the NAD(P)H: quinine oxidoreductase 1 (NQO1) gene 609 C>T polymorphism and esophageal cancer (EC) has been widely evaluated; however, the results are often irreproducible. We thus aimed to comprehensively evaluate this association through a meta-analysis. Data were extracted from 10 study populations involving 1390 EC patients and 1812 controls, and were analyzed using STATA software. Random-effects model was applied irrespective of between-study heterogeneity, which was assessed by the inconsistency index (I(2)) statistic. Publication bias was weighted by the funnel plot and Egger's test. Genotype distributions of the NQO1 gene 609 C>T polymorphism met Hardy-Weinberg equilibrium in controls for all studies. Allelic comparison indicated that NQO1 609 T allele conferred an increased risk (odds ratio [OR]=1.23; 95% confidence interval [CI]: 1.02-1.49; p=0.035), accompanying significant heterogeneity (I(2)=63.4%, p=0.003) and no publication bias (p(Egger)=0.391). This association was potentially enhanced in homozygous comparison (OR=1.58; 95% CI: 1.03-2.41; p=0.035; I(2)= 55.4%, p(heterogeneity)=0.017 and p(Egger)=0.461). Under dominant and recessive models, similar associations were obtained with an increased, although marginally significant risk. Subgroup analysis by ethnicity supported the risk profiles of the NQO1 gene 609 T allele and 609 TT genotype with EC in Eastern Asians, not in Europeans. Meta-regression analysis indicated that association between the NQO1 gene 609 C>T polymorphism and EC risk was significantly decreased with aging in case-patients (R(2)=-0.57; p=0.042). We expand previous studies by showing that the NQO1 gene 609 C>T polymorphism might contribute to EC occurrence, especially in Eastern Asians.

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“…Previous studies have suggested that more aggressive treatment selection among young patients results in similar overall survival despite more advanced stage at diagnosis. 14,15,17,23 Although some studies demonstrate improved 5-year overall survival among younger patients, others fail to replicate these findings. [14][15][16][17][18][19]23 In this series, patients aged less than 75 years had a similar rate of receiving any surgical therapy, although patients aged less than 65 years were more likely to receive aggressive treatment with induction therapy þ surgery than older patients.…”

Section: Discussionmentioning

confidence: 99%

“…Most studies are single-institution experiences limited by small sample sizes and conflicting findings relating to the presentation, treatment, and prognosis of this population; as such, the clinicopathologic presentation and outcomes of esophageal cancer in young patients are not well defined. [14][15][16][17][18][19][20][21][22][23][24][25] Further complicating current understanding of this disease in young patients is the lack of consensus as to what constitutes a ''young patient,'' with many studies arbitrarily selecting age less than 50 years. [14][15][16][17][18][19][20][21] Given that survival for this disease remains poor, esophageal cancer in young patients merits further investigation to better guide diagnosis and management in this population.…”

Section: Perspectivementioning

confidence: 99%

Higher clinical suspicion is needed for prompt diagnosis of esophageal adenocarcinoma in young patients

Nobel

Curry

Gennarelli

et al. 2020

The Journal of Thoracic and Cardiovascular Surgery

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Background: Esophageal cancer is considered a disease of the elderly. Although the incidence of esophageal adenocarcinoma in young patients is increasing, current guidelines for endoscopic evaluation of gastroesophageal reflux disease and Barrett's esophagus include age as a cutoff. There is a paucity of data on the presentation and treatment of esophageal cancer in young patients. Most studies are limited by small sample sizes, and conflicting findings are reported regarding delayed diagnosis and survival compared with older patients.Methods: A retrospective cohort study was performed using the National Cancer Database between 2004 and 2015. Patients with esophageal adenocarcinoma were divided into quartiles by age (18-57, 58-65, 66-74, 75þ years) for comparison. Clinicopathologic and treatment factors were compared between groups.From the

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Presentation and Survival of Operable Esophageal Cancer in Patients 55 Years of Age and Below

Cited by 25 publications

References 27 publications

Prognostic Factors for Oesophageal Cancer

Prognostic Factors for Oesophageal Cancer

Meta-Analysis of the NAD(P)H: Quinine Oxidoreductase 1 Gene 609 C>T Polymorphism with Esophageal Cancer Risk

Higher clinical suspicion is needed for prompt diagnosis of esophageal adenocarcinoma in young patients

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