Presentation, diagnosis, and treatment of a cerebellar tuberculoma: illustrative case

Capone, Stephen; Emechebe, Dokpe; Clair, Eric G. St.; Sadr, Ali; Feinberg, Michelle

doi:10.3171/case21170

Cited by 7 publications

(6 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…En la RM cerebral, los tuberculomas muestran lesiones realzadas en anillo después de la administración de contraste, que es heterogénea al igual que en un glioma y dependerá de la fase de evolución de las lesiones (7,8,13). La afectación de los pares craneales, el resultado de infiltración meníngea difusa, la localización preferentemente basilar y las lesiones tanto supratentoriales e infratentoriales contribuyen en el diagnóstico de la TBC (13,(14)(15)(16)(17). En casos de leptomeningitis tuberculosa, el contraste paramagnético en la RM muestra generalmente un engrosamiento meníngeo.…”

Section: Tuberculomaunclassified

Características imagenológicas actuales de resonancia magnética en los granulomas cerebrales más frecuentes

Castro-Magluff,

Castro-Velasco

2023

Rev Neuropsiquiatr

View full text Add to dashboard Cite

Los granulomas infecciosos y no infecciosos del encéfalo constituyen un constante desafío en su diagnóstico, dado que, desde el punto de vista clínico, muestran síntomas y signos, exámenes auxiliares e imágenes de características muy similares, razón por la cual demoran el tratamiento y demandan un diagnóstico histopatológico certero. Solo en estos últimos tiempos, con avances de la experiencia clínica, la epidemiología y las nuevas técnicas de resonancia magnética, se vislumbra la posibilidad de un diagnóstico no invasivo. Las formas infecciosas se encuentran en su mayoría en regiones de América Latina, Asia y África, aun cuando, debido a las migraciones y la globalización, también se están presentando de manera creciente en el resto del mundo. El presente trabajo describe las entidades que producen los granulomas más frecuentes y el apoyo diagnóstico que actualmente dispensan las imágenes de resonancia magnética.

show abstract

Section: Tuberculomaunclassified

Características imagenológicas actuales de resonancia magnética en los granulomas cerebrales más frecuentes

Castro-Magluff,

Castro-Velasco

2023

Rev Neuropsiquiatr

View full text Add to dashboard Cite

show abstract

“…Additionally, surgery can be performed in cases of diagnostic confusion caused by infratentorial tumors (Bouali et al, 2020). Cerebellar lesions may be more commonly resected due to their increased likelihood of causing these severe symptoms (Capone et al, 2021). Stereotactic craniotomy, excision of superficial small tuberculoma, and microsurgery are now used (Davis, Meintjes and Wilkinson, 2018).…”

Section: Surgerymentioning

confidence: 99%

“…Accordance in this case, after ATT for a year, head MRI evaluation showed gliosis and hemiatrophy on the right cerebellum. In conjunction with established ATT, resection of these lesions remains a viable treatment option that is both safe and effective (Capone et al, 2021).…”

Section: Stereotacticmentioning

confidence: 99%

“…In most developing countries, CNS tuberculoma is one of the first differential diagnoses of an enhancing intraaxial lesion (Capone et al, 2021). Tuberculoma imaging features are known to overlap with those of other intracranial focal lesions, such as chronic pyogenic brain abscess, fungal granulomas, neurocysticercosis healing stage, and lymphomas (Binesh, Zahir, and Bovanlu, 2013).…”

Section: Differential Diagnosismentioning

confidence: 99%

See 1 more Smart Citation

Cerebellar tuberculoma in an immunocompetent patient

Sihombing

Sugianto

2022

ijhs

View full text Add to dashboard Cite

Background: Tuberculosis infection of the Central Nervous System is the major cause of death and morbidity in developing countries. The clinical manifestations and radiological findings in tuberculoma are nonspecific. This article reports a rare case of cerebellar tuberculoma with the manifestation related to an intracranial mass and without the typical clinical symptoms of Tuberculosis in an immunocompetent patient. Case Report: A 20-year-old female with seizure, headache, and vertigo. A mass in the posterior fossa was revealed by Magnetic Resonance Imaging. Thorax scan results showed the Tuberculosis process. The patient then underwent surgery. Histopathological examination displayed chronic granulomatous inflammation and the presence of Acid-Fast Bacilli. The patient received anti-tuberculous drug treatment for one year and anti-seizure medication. Discussion: Cerebellar tuberculoma can resemble an intracranial tumor or cranial abscess. Diagnosis is based on clinical, radiological manifestations, and histopathological analysis. Surgical intervention still has a role in the treatment of this disease. The finding of Mycobacterium tuberculosis on histopathological examination is the gold standard in diagnosing Tuberculosis. Conclusions: Although it is rare, the involvement of Tuberculosis in the CNS should be taken into account in both immunocompetent and immunocompromised patients with neurological symptoms who are living in an endemic area.

show abstract

“…3 The most common clinical presentations are headache, nausea, vomiting, ataxia, diplopia, motor weakness, and seizure. [4][5][6][7] Since these symptoms are not specific and often resemble other intracranial space occupying lesion, intracranial tuberculoma should always be suspected in patient with tuberculosis experiencing symptoms of increased intracranial pressure. 2,3 Treatment of tuberculoma consist of anti-tuberculosis regimen, symptomatic treatment and surgical resection of the lesion.…”

Section: Introductionmentioning

confidence: 99%

Intracranial tuberculoma in human immunodeficiency virus-infected patient: a case report

Seputra¹,

Suhendro²,

Sumada³

et al. 2023

Int J Adv Med

View full text Add to dashboard Cite

Intracranial tuberculoma is one of the most devastating forms of Mycobacterium tuberculosis infection, presenting in 1% of all tuberculosis cases. This condition is significantly associated with high morbidity and mortality and frequently occurs in immunocompromised patients such as patient with human immunodeficiency virus (HIV) infection. Symptoms of intracranial tuberculoma include headache, nausea, vomiting, ataxia, diplopia, hemiparesis, and seizure. We reported a 34-years-old male patient presented with progressive left side weakness for 1 month prior to admission. Patient also complained of intermittent fever, headache, productive cough, night sweats, and unintentional weight loss. On neurological examination, power of left upper and lower limb was 3. Patient had a positive test result for HIV serologic examination. Chest X-ray showed infiltrate in the apical segment of right lower lobe of the lung. Mycobacterium tuberculosis was found on sputum gene expert examination. Head computed tomography (CT) scan showed multiple hypodense lesions with contrast enhancement in right caudate nucleus and right lentiform nucleus, suggestive for tuberculoma. Patient was treated with fixed-dose combination of antituberculosis, corticosteroid, and other symptomatic medication and showed a significant clinical improvement.

show abstract

Presentation, diagnosis, and treatment of a cerebellar tuberculoma: illustrative case

Cited by 7 publications

References 18 publications

Características imagenológicas actuales de resonancia magnética en los granulomas cerebrales más frecuentes

Características imagenológicas actuales de resonancia magnética en los granulomas cerebrales más frecuentes

Cerebellar tuberculoma in an immunocompetent patient

Intracranial tuberculoma in human immunodeficiency virus-infected patient: a case report

Contact Info

Product

Resources

About