‘Presenting CXR phenotype of H1N1’ flu compared with contemporaneous non-H1N1, community acquired pneumonia, during pandemic and post-pandemic outbreaks’

Minns, Fiona C.; mhuineachain, A Ni; Beek, Edwin Jacques Rudolph van; Ritchie, Gordon; Hill, Adam T.; Murchison, John T

doi:10.1016/j.ejrad.2015.05.016

Cited by 4 publications

(4 citation statements)

References 15 publications

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“…Bilateral affectation through chest X-rays was four times more frequent in cases compared to controls (61.6 vs 14.8%, respectively; p < 0.01), with less predominance of alveolar pattern (76.8% vs 87%; p < 0.01) but with higher interstitial (8.7% vs 0.7%) and patchy appearance (5% vs 1.1%). These results are similar to previous studies where 71% of patients with H1N1 CAP (40/56) [12] and 40.4% (19/47) present bilateral affectation [21] and the alveolar pattern does not surpass 50% [12, 13, 26]. These findings might be extremely helpful when differentiating H1N1 CAP versus NVI CAP.…”

Section: Discussionsupporting

confidence: 90%

Influenza A H1N1 Community-Acquired Pneumonia: Characteristics and Risk Factors—A Case-Control Study

Abelleira

Ruano-Raviña

Lama

et al. 2019

Canadian Respiratory Journal

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Introduction. Influenza A H1N1 community-acquired pneumonia (CAP) is a quite frequent respiratory disease. Despite being considered more serious than other CAPs, there are very few studies comparing its characteristics with noninfluenza CAP. We aim to establish the differences between pneumonia due to H1N1 virus and pneumonia not caused by H1N1 influenza virus and to determine the probability that a pneumonia is due to an H1N1 virus infection based on the most relevant variables. Methods. We used a case-control study where cases were H1N1 CAP patients with confirmed microbiological diagnosis and controls were patients with CAP admitted to hospital. H1N1 and other influenza types were discarded among controls. We calculated the probability of being a case or control using multivariate logistic regression. Results. We included 99 cases and 270 controls. Cases were younger than controls (53 vs 71 years, respectively). Mortality was much higher for H1N1 patients (13% vs 0.3%), and admission to intensive care unit was more frequent for H1N1 cases. The variables most associated with presenting H1N1 CAP were bilateral affectation on chest X-rays (OR: 5.70; 95% CI 2.69–10.40), followed by presence of arthromyalgias, with cases presenting close to three times more arthromyalgias compared to controls. Low leukocytes count and high AST values were also significantly associated with H1N1 CAP. H1N1 CAPs are characterized by bilateral affectation, low leukocyte count, presence of arthromyalgias, and high AST. Conclusions. A few and easy to obtain clinical parameters might be extremely useful to distinguish H1N1 CAP from CAPs of other origin.

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Section: Discussionsupporting

confidence: 90%

Influenza A H1N1 Community-Acquired Pneumonia: Characteristics and Risk Factors—A Case-Control Study

Abelleira

Ruano-Raviña

Lama

et al. 2019

Canadian Respiratory Journal

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“…In parallel, CXRs were performed in the same patients at the same time point. The median LUS global score was 7 , whereas the median CXR global score was 9 (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13). The LUS global score positively correlated with the FiO2 requirement at the time of the US examination (r = 0.36; p = 0.03) (Figure 2).…”

Section: Ultrasound Evaluationmentioning

confidence: 96%

“…CXR is recommended as first level assessment by several scientific societies (American College of Radiology, Society of Thoracic Radiology) in the context of the SARS-CoV-2 pandemic [3]. Predominant CXR features in patients with COVID-19 include lower lobe, peripheral, bilateral ground glass opacities (GGO) or consolidations [2], similar to other forms of viral pneumonias, such as the H1N1 strain [4]. Yet, CXR could be normal in as many as 31% cases, peaking its sensibility in patients with advanced disease [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Clinical Features and Chest Imaging as Predictors of Intensity of Care in Patients with COVID-19

Cocconcelli

Biondini

Giraudo

et al. 2020

JCM

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Coronavirus disease 2019 (COVID-19) has rapidly become a global pandemic with lung disease representing the main cause of morbidity and mortality. Conventional chest-X ray (CXR) and ultrasound (US) are valuable instruments to assess the extent of lung involvement. We investigated the relationship between CXR scores on admission and the level of medical care required in patients with COVID-19. Further, we assessed the CXR-US correlation to explore the role of ultrasound in monitoring the course of COVID-19 pneumonia. Clinical features and CXR scores were obtained at admission and correlated with the level of intensity of care required [high- (HIMC) versus low-intensity medical care (LIMC)]. In a subgroup of patients, US findings were correlated with clinical and radiographic parameters. On hospital admission, CXR global score was higher in HIMCs compared to LIMC. Smoking history, pO2 on admission, cardiovascular and oncologic diseases were independent predictors of HIMC. The US score was positively correlated with FiO2 while the correlation with CXR global score only trended towards significance. Our study identifies clinical and radiographic features that strongly correlate with higher levels of medical care. The role of lung ultrasound in this setting remains undetermined and needs to be explored in larger prospective studies.

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“…Opacities seen in pediatric COVID-19 pneumonia often have less well-defined borders. Swine origin influenza A Swine origin influenza A (H1N1) was responsible for a pandemic of viral respiratory illness in 2009 and subsequently joined other influenza viruses that continue to circulate with occasional sporadicoutbreaks 41. The most common clinical symptoms include fever and cough, although additional symptoms including rhinorrhea, sore throat, headache, chest pain, vomiting, abdominal, pain, diarrhea, and dyspnea have been reported with less frequency 42.…”

mentioning

confidence: 99%

Practical guide for pediatric pulmonologists on imaging management of pediatric patients with COVID‐19

Foust

McAdam

Chu

et al. 2020

Pediatric Pulmonology

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Understanding of coronavirus disease 2019 is rapidly evolving with new articles on the subject daily. This flood of articles can be overwhelming for busy practicing clinicians looking for key pieces of information that can be applied in daily practice. This review article synthesizes the reported imaging findings in pediatric Coronavirus disease 2019 (COVID‐19) across the literature, offers imaging differential diagnostic considerations and useful radiographic features to help differentiate these entities from COVID‐19, and provides recommendations for requesting imaging studies to evaluate suspected cases of pediatric COVID‐19.

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‘Presenting CXR phenotype of H1N1’ flu compared with contemporaneous non-H1N1, community acquired pneumonia, during pandemic and post-pandemic outbreaks’

Cited by 4 publications

References 15 publications

Influenza A H1N1 Community-Acquired Pneumonia: Characteristics and Risk Factors—A Case-Control Study

Influenza A H1N1 Community-Acquired Pneumonia: Characteristics and Risk Factors—A Case-Control Study

Clinical Features and Chest Imaging as Predictors of Intensity of Care in Patients with COVID-19

Practical guide for pediatric pulmonologists on imaging management of pediatric patients with COVID‐19

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