Presenting signs of retinoblastoma

Abramson, David H.; Frank, Christopher M.; Susman, Mark; Whalen, Mary P.; Dunkel, Ira J.; Boyd, Norman W.

doi:10.1016/s0022-3476(98)70028-9

Cited by 247 publications

(138 citation statements)

References 10 publications

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“…In the United States, an evaluation of 1265 patients revealed that the most common presenting signs included leukocoria (56%), strabismus (24%), and poor vision (8%). 6 Further study on a cohort of 1196 eyes found median age at presentation of 15 months with 51% male, 49% female and 53% unilateral, 47% bilateral. 7 Zhao et al 8 from China reviewed 470 eyes and found leukocoria (47%) to be most common.…”

Section: Clinical Features Of Retinoblastomamentioning

confidence: 95%

Retinoblastoma frontiers with intravenous, intra-arterial, periocular, and intravitreal chemotherapy

Shields

Fulco

Arias

et al. 2012

Eye

223

205

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In this report, we explore retinoblastoma diagnostic accuracy and review chemotherapy alternatives for retinoblastoma using intravenous, intra-arterial, periocular, and intravitreal routes. A review of 2775 patients referred for management of retinoblastoma, disclosed 78% with confirmed retinoblastoma and 22% with simulating lesions, termed pseudoretinoblastomas. Children r2 years old showed leading pseudoretinoblastomas of persistent fetal vasculature, Coats disease, and vitreous haemorrhage, whereas those 45 years showed simulators of Coats, toxocariasis, and familial exudative vitreoretinopathy. The diagnosis of retinoblastoma should be established before planning therapeutic strategy. Chemotherapy strategy depends on tumour laterality and stage of disease. If bilateral retinoblastoma, intravenous chemotherapy (IVC) is important as first-line therapy for control of intraocular disease, prevention of metastasis, and reduction in prevalence of pinealoblastoma and long-term second malignant neoplasms. Bilateral groups D and E retinoblastoma receive additional subtenon's carboplatin boost for improved local control. If unilateral disease is present, then intra-arterial chemotherapy (IAC) is often considered. IAC can be salvage therapy following chemoreduction failure. Unilateral retinoblastoma of groups D and E are managed with enucleation or globeconserving IVC and/or IAC. Intravitreal chemotherapy is cautiously reserved for recurrent vitreous seeds following other therapies. In conclusion, the strategy for retinoblastoma management with chemotherapy depends on tumour laterality and stage of disease. Bilateral retinoblastoma is most often managed with IVC and unilateral retinoblastoma with IAC, but if advanced stage, combination IVC plus IAC or enucleation.

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Section: Clinical Features Of Retinoblastomamentioning

confidence: 95%

Retinoblastoma frontiers with intravenous, intra-arterial, periocular, and intravitreal chemotherapy

Shields

Fulco

Arias

et al. 2012

Eye

223

205

View full text Add to dashboard Cite

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“…O sucesso do tratamento do retinoblastoma depende da habilidade do pediatra em detectar a doença ainda em seu estágio intra-ocular. É imprescindível que o pediatra saiba reconhecer sinais como leucocoria (mancha branca no olho) e estrabismo 20 21 . Este atraso deve-se, provavelmente, à desinformação da população leiga e médica.…”

Section: Retinoblastomaunclassified

Diagnóstico precoce do câncer infantil: responsabilidade de todos

Rodrigues¹

2003

Rev. Assoc. Med. Bras.

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RESUMO -OBJETIVO. Alertar para a necessidade do conhecimento e investigação dos sinais e sintomas iniciais do câncer infantil, bem como para a responsabilidade de todos envolvidos no processo do seu diagnóstico precoce a fim de melhorar os nossos índices de cura.MÉTODOS. Revisão da literatura através de consulta ao Medline. RESULTADOS. O diagnóstico do câncer infantil é um processo complexo e muitas são as variáveis que parecem influenciá-lo. A detecção precoce e o pronto início do tratamento têm importante papel na redução da mortalidade e morbidade do tratamento. O melhor entendimento da relação entre estes fatores é de fundamental importância para o desenvolvimento de estratégias de saúde pública para detecção precoce do câncer infantil.CONCLUSÃO. Muitos fatores parecem estar associados ao atraso do diagnóstico do câncer infantil. O tempo que decorre entre o primeiro sintoma e o diagnóstico depende da idade da criança e do tipo do tumor, principalmente. Determinar os sinais e sintomas que devem alertar para a possibilidade de doenças malignas ainda é um desafio.UNITERMOS: Câncer infantil. Diagnóstico. Sinais e sintomas.

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“…27,28 A study from Taiwan has reported proptosis in 17% cases, whereas another study in Nigerian children found proptosis in 85% cases. 13,29 Delayed presentation was observed in majority of the cases.…”

Section: Discussionmentioning

confidence: 99%