Presenting symptoms of COVID-19 in children: a meta-analysis of published studies

Assaker, Rita; Colas, Anne-Emmanuelle; Julien-Marsollier, Florence; Bruneau, B.; Marsac, Lucile; Greff, B.; Tri, Nathalie; Fait, Charlotte; Brasher, Christopher; Dahmani, Souhayl

doi:10.1016/j.bja.2020.05.026

Cited by 84 publications

(83 citation statements)

References 8 publications

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“…This highlights similar trends in different continents. As shown in other studies ( 4 , 5 ), PCR positive paediatric patients ( 5 ) were likely to be asymptomatic and deny contact with COVID-19+ persons. The percentage of SARS-CoV-2 PCR positive results in our cohort did tend to increase with increased community disease transmission.…”

supporting

confidence: 56%

“…One of the crucial questions facing physicians and healthcare policy managers during this pandemic is whether to employ mandatory SARS-CoV-2 testing for all patients admitted to hospital. This question is particularly pertinent in children, given higher asymptomatic disease rates and increased difficulties when performing nasopharyngeal swab testing ( 3 , 4 , 5 ). French guidelines require physicians to test all hospitalised paediatric patients before surgery ( 4 ).…”

mentioning

confidence: 99%

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Mandatory preoperative SARS-CoV-2 infection screening policies for paediatric surgery

Colas

Azale

Ayanmanesh

et al. 2021

British Journal of Anaesthesia

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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supporting

confidence: 56%

mentioning

confidence: 99%

Mandatory preoperative SARS-CoV-2 infection screening policies for paediatric surgery

Colas

Azale

Ayanmanesh

et al. 2021

British Journal of Anaesthesia

Self Cite

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“…These estimates ranged from 7.4% 19 to 17.7%. 28 All studies which reported fatigue and myalgia did so as 'fatigue or myalgia', with the exception of Assaker et al 22 who reported myalgia in 14% and fatigue in 8%.…”

Section: Resultsmentioning

confidence: 99%

“…We included 18 reviews in our analysis. [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] Characteristics of the included reviews are shown in table 1; all are freely available online (see online supplemental appendix table 2). All reviews were in English.…”

Section: Resultsmentioning

confidence: 99%

Systematic review of reviews of symptoms and signs of COVID-19 in children and adolescents

Viner¹,

Ward²,

Hudson³

et al. 2020

Arch Dis Child

172

110

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ObjectiveTo undertake a systematic review of reviews of the prevalence of symptoms and signs of COVID-19 in those aged under 20 years.DesignNarrative systematic review of reviews. PubMed, medRxiv, Europe PMC and COVID-19 Living Evidence Database were searched on 9 October 2020.SettingAll settings, including hospitalised and community settings.PatientsChildren and young people (CYP) under age 20 years with laboratory-proven COVID-19.Study review, data extraction and qualityPotentially eligible articles were reviewed on title and abstract by one reviewer. Quality was assessed using the modified AMSTARS criteria and data were extracted from included studies by two reviewers.Main outcome measuresPrevalence of symptoms and signs of COVID-19.Results1325 studies were identified and 18 reviews were included. Eight were high quality, 7 medium and 3 low quality. All reviews were dominated by studies of hospitalised children. The proportion of asymptomatic CYP ranged from 14.6% to 42%. Fever and cough were the the most common symptoms; proportions with fever ranged from 46% to 64.2% and with cough from 32% to 55.9%. All other symptoms or signs including rhinorrhoea, sore throat, headache, fatigue/myalgia and gastrointestinal symptoms including diarrhoea and vomiting were infrequent, occurring in less than 10%–20%.ConclusionsFever and cough are the most common symptoms in CYP with COVID-19, with other symptoms infrequent. Further research on symptoms in community samples are needed to inform pragmatic identification and testing programmes for CYP.

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“…Pediatric cases of COVID-19 infection typically present as mild (37%) or moderate (45%) upper respiratory tract infections and are rarely severe or critical. 3 While most patients manifest with fever and respiratory symptoms, other organs and systems can be affected resulting in a wide range of extrapulmonary manifestations, including renal, cardiac, and neurological manifestations. 4 We present a case of COVID-19 infection in an adolescent presenting with respiratory symptoms and muscle weakness which resulted in death within 3 days of admission.…”

Section: Introductionmentioning

confidence: 99%

Adolescent COVID-19-Associated Fatal Rhabdomyolysis

Anwar

Lawati

2020

J Prim Care Community Health

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Coronavirus disease 2019 (COVID-19) has become an urgent global health priority. Although most patients with COVID-19 manifest with fever and respiratory tract symptoms, COVID-19 infections may also involve other organs and extrarespiratory manifestations, including cardiac, gastrointestinal, hepatic, renal, and neurological symptoms. This case describes a 16-year-old boy who presented with fever, sore throat, myalgia, and subsequently with shortness of breath. A diagnosis of COVID-19 was confirmed by polymerase chain reaction. His condition deteriorated and he died within 3 days of admission. An evaluation of his past medical history confirmed an episode of viral illness which had progressed to myositis and rhabdomyolysis 1 year prior. Clinicians should be aware of this complication and maintain a high index of suspicion in cases of COVID-19 presenting with extrapulmonary symptoms.

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Presenting symptoms of COVID-19 in children: a meta-analysis of published studies

Cited by 84 publications

References 8 publications

Mandatory preoperative SARS-CoV-2 infection screening policies for paediatric surgery

Mandatory preoperative SARS-CoV-2 infection screening policies for paediatric surgery

Systematic review of reviews of symptoms and signs of COVID-19 in children and adolescents

Adolescent COVID-19-Associated Fatal Rhabdomyolysis

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