Presepsin and procalcitonin as biomarkers of systemic bacterial infection in patients with rheumatoid arthritis

Tsujimoto, Kohei; Hata, Atsuko; Fujita, Masaaki; Hatachi, Saori; Yagita, Masato

doi:10.1111/1756-185x.12899

Cited by 27 publications

(21 citation statements)

References 15 publications

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“…Many of these patients who report to tertiary centres receive primary treatment in the form of antibiotic which makes the diagnosis difficult because of earlier administration of emperical antibiotics the considered gold standard test ie pus culture and sensitivity give sterile culture after 72 hours of incubation. The sensitivity and specificity of pus culture is 40-60% and 100% respectively 18,19 . Because of these problems diagnosis and treatment gets delayed in these patients leading to many complications which are very difficult to tackle even with very powerful antibiotics.…”

Section: Discussionmentioning

confidence: 99%

“…Use of powerful antibiotics becomes frequent in such circumstances which lead to another bigger problem of development antibiotic resistance in the microorganisms. Which will be difficult to manage because the availability of such strong antibiotics very few in the list 18,19 and once the microorganism becomes resistant to these strong antibiotics the infection will become life threatening. So we need an accurate and OPD basis test for these patients for early diagnosis and the earliest intervention in these patients to avoid aforesaid problems impending over community.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of Serum Procalcitonin Levels as a Diagnostic Marker of Early Infection in Patients With Acute Bone and Joint Infection: A Hospital Based Study

Pandey¹

2019

IJOTSS

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Background: Acute osteomyelitis and septic arthritis are most common acute infectious conditions of bone encountered at the emergency or outpatient department at hospitals. Both septic arthritis and osteomyelitis are threat for joint destruction, physeal damage and osteonecrosis, which warrants prompt and specific diagnosis and treatment. This study endeavours to evaluate Procalcitonin as diagnostic tool for earliest and specific diagnosis of acute bone and joint infection. Methods: This is a prospective type hospital based study conducted at a tertiary care hospital ,carried out between October 2015 to April 2017 which included total of 78 participants divided in two groups ,the cases and control group, each containing 39 patients. Clinical parameters as fever, pain, swelling and laboratory findings as Total Leucocyte Count(TLC), Erythrocyte Sedimentation Rate(ESR), C Reactive protein(CRP) and Procalcitonin(PCT) were measured. Baseline characteristic of the two groups compared. The sensitivity, specificity and p-values were compared using chi square and fisher's exact test, SPSS software version 20 used. Results: Total of 78 patients participated, 39 taken as cases and 39 as control. Out of 78 patients, males-48 (61.54%), and females-30(38.46%) with average age of participants as 23.5 years. ESR, CRP and TLC and procalcitonin was found to be elevated in all the cases .The P value for CRP and Procalcitonin was 0.00001 and significant correlation was observed between cases and PCT serum level. For septic arthritis the specificity of Procalcitonin came

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evaluation of Serum Procalcitonin Levels as a Diagnostic Marker of Early Infection in Patients With Acute Bone and Joint Infection: A Hospital Based Study

Pandey¹

2019

IJOTSS

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“…С целью оценки ПСП и ПК в качестве маркеров бактериальной инфекции K.Tsuimoto и соавт. [22] обследовали 4 группы испытуемых: 1) РА с бактериальной инфекцией (n=26); 2) РА без инфекции с уровнем СРБ >0,3 мг/дл (n=45); 3) РА без инфекции с уровнем СРБ <0,3 мг/дл (n=55); 4) 25 здоровых лиц -контроль. Оба показателя были максимальными в 1-й группе и значимо превышали таковые во 2-й и 3-й группах (p<0,0001).…”

Section: пресепсинunclassified

Role of biomarkers in the diagnosis of bacterial infections in rheumatic diseases

Белов¹,

Тарасова²,

Муравьева³

2019

Naučno-praktičeskaâ revmatologiâ

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In modern rheumatology, the problem of differential diagnosis of bacterial infection and active rheumatic process still retains its relevance. At the same time, it is very important to search for a biomarker - the gold standard for the diagnosis of an infection in patients with rheumatic diseases (RDs) in order to rapidly determine a treatment policy. This review analyzes the diagnostic significance and possibility of using some laboratory markers for bacterial infections in modern rheumatology. It emphasizes the importance of a multimarker approach that allows increasing the significance of individual parameters in the diagnosis of infections in RD.

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“…Differenzialdiagnostisch kann die Bestimmung von Prokalkitonin und Presepsin hilfreich sein. Der Aussagewert bezüglich einer drohenden Sepsis ist bei Rheumatoider Arthritis zumindest spezifischer als der Wert des CRP [29].…”

Section: Der Akute Periprothetische Infektunclassified

Komplikationen in der Hüftchirurgie beim Rheumatiker

Bause

2018

Akt Rheumatol

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ZusammenfassungDie Erfolge der modernen Hüftendoprothetik sind unbestritten und ermöglichen vielen Patienten eine weiterhin aktive Lebensgestaltung. Gerade Patienten mit rheumatischer Grunderkrankung, die verhältnismäßig häufiger und in jüngerem Lebensalter betroffen sind, profitieren hiervon. Obwohl die technische Durchführung der Endoprothetik hierbei ähnlichen Gesetzen unterliegt wie bei arthrotischer Grunderkrankung sind doch krankheitsspezifische Besonderheiten zu beachten. Aus dem Blickwinkel einer auf Rheumachirurgie spezialisierten Klinik werden Besonderheiten der Endoprothetik rheumatischer Hüften anhand eigener Erfahrungen und der Literatur diskutiert. Hierbei wird sowohl auf die Primärversorgung als auch die Revisionschirurgie eingegangen. Revisionsgründe wie aseptische und septische Lockerungen, Luxationen, Materialversagen und periprothetische Frakturen werden erläutert. Besonders betrachtet wird die z. T. schwierige Differenzialdiagnose zwischen septischen und aseptischen Lockerungen. Im Rahmen einer Schubsituation der Grunderkrankung und gleichzeitiger Immunsuppression kann die Abgrenzung zu einem periprothetischen Infekt schwierig sein. Hier ist aufgrund der rasch ansteigenden Komplikationsrate besonders bei multilokulären Infekten eine schnelle Differenzierung und schnelle adäquate Therapieeinleitung erforderlich.

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Presepsin and procalcitonin as biomarkers of systemic bacterial infection in patients with rheumatoid arthritis

Abstract: Presepsin and procalcitonin may be useful to identify infection in RA patients. Presepsin may better reflect infection severity than procalcitonin.

Cited by 27 publications

References 15 publications

Evaluation of Serum Procalcitonin Levels as a Diagnostic Marker of Early Infection in Patients With Acute Bone and Joint Infection: A Hospital Based Study

Evaluation of Serum Procalcitonin Levels as a Diagnostic Marker of Early Infection in Patients With Acute Bone and Joint Infection: A Hospital Based Study

Role of biomarkers in the diagnosis of bacterial infections in rheumatic diseases

Komplikationen in der Hüftchirurgie beim Rheumatiker

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