Presepsin as a novel sepsis biomarker

Abstract

BACKGROUND:In 2004, a new biomarker sCD14-subtypes (presepsin) was found and its value was shown in the diagnosis and evaluation of sepsis. This article is a brief overview of the new biomarker.DATA SOURCES: A literature search using multiple databases was performed for articles, especially meta-analyses, systematic reviews, and randomized controlled trials. RESULTS:Compared with other markers, presepsin seems to have a better sensitivity and specificity in the diagnosis of sepsis. Presepsin as a biom1arker is not only suitable for the early diagnosis of sepsis, but also for the assessment of its severity and prognosis.CONCLUSIONS: Presepsin has a higher sensitivity and specifi city in the diagnosis of sepsis as a new biomarker, and is a predictor for the prognosis of sepsis. More importantly, preseptin seems to play a crucial role as a supplemental method in the early diagnosis of sepsis. Since there is no multicenter study on the relationship between presepsin and sepsis, further studies on the clinical values of presepsin are needed.

Ang-2, Tie-2, and Ang-2/Tie-2 ratio serum levels as diagnostic and prognostic biomarkers of sepsis in critically ill patients

“…The survival rates at 60 days were 20% [n=8] in Group A and 29.4% [10] in Group B. There was a significant difference between the two groups with higher mortality rate and shorter survival times for Group A [p=0.0169].…”

“…Soluble CD14 subtype (sCD14-ST), also known as presepsin, is a novel and promising biomarker with a higher sensitivity and specificity in the diagnosis of sepsis, [10] and in patients with suspected severe sepsis and septic shock, presepsin is considered to be a valuable diagnostic tool for assessing the severity of sepsis compared to PCT, IL-6, CRP and WBC [11].…”

Usefulness of Presepsin (sCD14-ST) in diagnosis of Infective Endocarditis - preliminary results of an observational study / Utilitatea presepsinului (sCD14-ST) în Endocardita Infecțioasă –rezultate preliminare ale unui studiu observațional

“…Another interesting feature of presepsin seems to be the ability to predict outcome in sepsis and also in acute pneumonia (21,22). Future issues remain to be solved concerning presepsin as a new biomarker, such as: influence of age and different medical conditions (e.g renal or hepatic dysfunctions), optimal cut off values in specific types of infections (20,23).…”

A validation of presepsin levels in kidney dysfunction patients: four case reports

“…Endo et al [3] demonstrated that PSPs in two CKD patients without sepsis were 9,036 and 1,362, while their PCTs were 0.525 and 0.382 ng/ml, respectively. Zou et al [7] reported that the median PSP in non-sepsis kidney dysfunction patients was 1,607 (range, 454-8,516) and those in sepsis kidney dysfunction patients was 1,523 (range, 293-16,764); they also mentioned that there was no significant difference between the two groups. Our four case studies present four patients who revealed high PSP values without elevation of other conventional biomarkers or symptoms of sepsis.…”