Periodontal disease is characterized as an inflammatory process that damages the periodontal lining and/or support tissues. Peri-implantitis is among the periodontal alterations, being caused by bacterial biofilm causing loss of underlying bone insertion, leading to modifications in its architecture that form intraosseous defects of various types. For the treatment of peri-implantitis there are non-surgical, surgical, resective, regenerative, combined techniques and the decision-making will depend on the degree of the bone defect. Therefore, guided bone regeneration (GBR) is an efficient and simple technique for bone augmentation, which is widely used to restructure bone defects that occur in the alveolar ridge and in the peri-implant region. Biomaterials are alternatives to be used in guided bone regeneration due to their excellent biocompatibility, osteoinductive properties, low degradation rate and their hydrophilicity, which collaborates with the absorption of blood cells and proteins that will help in osseointegration. Female, 58-year-old normosistemic patient, attended a private dental office complaining of pain, bad smell, bleeding and bad taste in the peri-implant region referring to element 25, on its distal face to the mesial face of the element tooth 26. After imaging exams, periodontal probing and the patient's past history, extraction of element 26 was performed, decontamination protocol of the implant surface of 25 through mechanical, chemical and physical means performing antimicrobial photodynamic therapy and finally, a guided bone regeneration was performed, using the allogeneic bone grafting technique associated with a polytetrafluoroethylene membrane in its expanded form (e-PTFE) for recovery of the bone defect and alveolar preservation. Thus, guided bone regeneration has shown high success rates and greater predictability when well indicated and performed, making it important for the maintenance of periodontal and peri-implant health.