We are moving towards a future that must be more sustainable in several aspects of society. Culture and cultural heritage have been recognized as indispensable parts of the sustainable growth of society, and the conservation model implemented in Europe has been considered as an example to follow at the economic, environmental, and social levels. The achievement of excellent results and the development of new technologies for the conservation of cultural heritage have highlighted the fundamental need for a method of sustainable conservation. In this commentary paper, we discuss two aspects that can contribute to sustainability in the future of conservation science: the use of innovative chemical products and the monitoring of outdoor sites by means of the forecast of the impact of dangerous factors on artistic surfaces. We are focusing mainly on the material aspect of cultural assets and how hard science can help in sustainable conservation. Even if the concept of sustainability has an ever-growing presence in our society, and different approaches have been given in different fields, it is still difficult to come up with a specific definition that can include the various hues of the world of cultural heritage conservation. The case studies presented in this paper are related to the European area and the advancements made for the sustainable preservation of such heritage. Considering the results obtained from both the chemical and the forecast side, we will try to summarize concisely the tasks that must be achieved in order to indicate as sustainable an approach to diagnostics for cultural heritage, including both the trans-disciplinary features of cultural heritage science and the scientific conservation of materials.