Preservation of Motor Function After Resection of Lower-Grade Glioma at the Precentral Gyrus and Prediction by Presurgical Functional Magnetic Resonance Imaging and Magnetoencephalography

Izutsu, Nobuyuki; Kinoshita, Manabu; Yanagisawa, Takufumi; Nakanishi, Koji; Sakai, Mio; Kishima, Haruhiko

doi:10.1016/j.wneu.2017.07.152

Cited by 8 publications

(7 citation statements)

References 9 publications

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“…The reliability of the findings from each technique was most frequently derived from the comparison with intra-operative mapping [ 11 , 23 , 28 , 44 , 45 , 46 , 48 , 49 ]. Alternatively, the confirmation of a good pre-operative assessment was given in the case of successful imaging-guided resection [ 47 , 50 , 51 , 53 , 54 , 55 ] and/or when the findings matched with those achieved by other techniques, such as the Wada test (in the case of laterality assessment; [ 47 , 48 , 50 ]) or stimulation methods including transcranial magnetic stimulation (TMS; [ 51 ]). Two studies had slightly different purposes than pre-operative planning.…”

Section: Direct Comparison Between Fmri and Meg In Pre-operative Mappingmentioning

confidence: 99%

Pre-Operative Functional Mapping in Patients with Brain Tumors by fMRI and MEG: Advantages and Disadvantages in the Use of One Technique over the Other

Cargnelutti

Tomasino

2023

Life

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Pre-operative mapping of brain functions is crucial to plan neurosurgery and investigate potential plasticity processes. Due to its availability, functional magnetic resonance imaging (fMRI) is widely used for this purpose; on the other hand, the demanding cost and maintenance limit the use of magnetoencephalography (MEG), despite several studies reporting its accuracy in localizing brain functions of interest in patient populations. In this review paper, we discuss the strengths and weaknesses of both techniques, from a methodological perspective first; then, we scrutinized and commented on the findings from 16 studies, identified by a database search, that made pre-operative assessments using both techniques in patients with brain tumors. We commented on the results by accounting for study limitations associated with small sample sizes and variability in the used tasks. Overall, we found that, although some studies reported the superiority for MEG, the majority of them underlined the complementary use of these techniques and suggested assessment using both. Indeed, both fMRI and MEG present some disadvantages, although the development of novel devices and processing procedures has enabled ever more accurate assessments. In particular, the development of new, more feasible MEG devices will allow widespread availability of this technique and its routinely combined use with fMRI.

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Section: Direct Comparison Between Fmri and Meg In Pre-operative Mappingmentioning

confidence: 99%

Pre-Operative Functional Mapping in Patients with Brain Tumors by fMRI and MEG: Advantages and Disadvantages in the Use of One Technique over the Other

Cargnelutti

Tomasino

2023

Life

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“…We performed stereotactic tissue sampling under craniotomy with a neuronavigation system (BrainLab CURVE; BrainLab, Munich, Germany) assisting the surgery. Surgeries were performed either under general anesthesia or awake craniotomy [17]. We performed biopsies at the earliest stage of operation to minimize the effects of brain-shift during resection.…”

Section: Image Fusion/registration and Stereotactic Image-guided Tissue Samplingmentioning

confidence: 99%

Magnetic Resonance Relaxometry for Tumor Cell Density Imaging for Glioma: An Exploratory Study via 11C-Methionine PET and Its Validation via Stereotactic Tissue Sampling

Kinoshita

Uchikoshi

Tateishi

et al. 2021

Cancers

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One of the most crucial yet challenging issues for glioma patient care is visualizing non-contrast-enhancing tumor regions. In this study, to test the hypothesis that quantitative magnetic resonance relaxometry reflects glioma tumor load within tissue and that it can be an imaging surrogate for visualizing non-contrast-enhancing tumors, we investigated the correlation between T1- and T2-weighted relaxation times, apparent diffusion coefficient (ADC) on magnetic resonance imaging, and 11C-methionine (MET) on positron emission tomography (PET). Moreover, we compared the T1- and T2-relaxation times and ADC with tumor cell density (TCD) findings obtained via stereotactic image-guided tissue sampling. Regions that presented a T1-relaxation time of >1850 ms but <3200 ms or a T2-relaxation time of >115 ms but <225 ms under 3 T indicated a high MET uptake. In addition, the stereotactic tissue sampling findings confirmed that the T1-relaxation time of 1850–3200 ms significantly indicated a higher TCD (p = 0.04). However, ADC was unable to show a significant correlation with MET uptake or with TCD. Finally, synthetically synthesized tumor load images from the T1- and T2-relaxation maps were able to visualize MET uptake presented on PET.

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“…Functional studies using fMRI, repetitive TMS (rTMS), and MEG of patients pre- and post-resection of low-grade gliomas have shown that cortical functional reorganization frequently occurs [ 45 , 46 , 47 , 48 , 49 ]. Several studies have identified neuroplasticity in the context of slow-growing lesions such as low-grade gliomas and provide support for a model by which staged surgery may be favorable in this clinical context to drive plasticity of subcortical pathways [ 50 , 51 ].…”

Section: Employing Neuromodulation Strategies In Glioma Surgery To Influence Peri-operative Functional Reorganization and Promote Post-opmentioning

confidence: 99%

A Network-Based Approach to Glioma Surgery: Insights from Functional Neurosurgery

Samuel

Vetkas

Pancholi

et al. 2021

Cancers

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The evaluation and manipulation of structural and functional networks, which has been integral to advancing functional neurosurgery, is beginning to transcend classical subspecialty boundaries. Notably, its application in neuro-oncologic surgery has stimulated an exciting paradigm shift from the traditional localizationist approach, which is lacking in nuance and optimization. This manuscript reviews the existing literature and explores how structural and functional connectivity analyses have been leveraged to revolutionize and individualize pre-operative tumor evaluation and surgical planning. We describe how this novel approach may improve cognitive and neurologic preservation after surgery and attenuate tumor spread. Furthermore, we demonstrate how connectivity analysis combined with neuromodulation techniques can be employed to induce post-operative neuroplasticity and personalize neurorehabilitation. While the landscape of functional neuro-oncology is still evolving and requires further study to encourage more widespread adoption, this functional approach can transform the practice of neuro-oncologic surgery and improve the care and outcomes of patients with intra-axial tumors.

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Preservation of Motor Function After Resection of Lower-Grade Glioma at the Precentral Gyrus and Prediction by Presurgical Functional Magnetic Resonance Imaging and Magnetoencephalography

Cited by 8 publications

References 9 publications

Pre-Operative Functional Mapping in Patients with Brain Tumors by fMRI and MEG: Advantages and Disadvantages in the Use of One Technique over the Other

Pre-Operative Functional Mapping in Patients with Brain Tumors by fMRI and MEG: Advantages and Disadvantages in the Use of One Technique over the Other

Magnetic Resonance Relaxometry for Tumor Cell Density Imaging for Glioma: An Exploratory Study via 11C-Methionine PET and Its Validation via Stereotactic Tissue Sampling

A Network-Based Approach to Glioma Surgery: Insights from Functional Neurosurgery

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